High performance liquid chromatographic method for the determination of guaifenesin in pharmaceutical syrups and in environmental samples

A simple, precise, rapid, and accurate reversed – phase high performance liquid chromatographic method has been developed for the determination of guaifenesin in pure from pharmaceutical formulations.andindustrial effluent. Chromatography was carried out on supelco L7 reversed- phase column (25cm × 4.6mm), 5 microns, using a mixture of methanol –acetonitrile-water: (80: 10 :10 v/v/v) as a mobile phase at a flow rate of 1.0 ml.min-1. Detection was performed at 254nm at ambient temperature. The retention time for guaifenesin was found 2.4 minutes. The calibration curve was linear (r= 0.9998) over a concentration range from 0.08 to 0.8mg/ml. Limit of detection (LOD) and limit of quantification ( LOQ) were found 6µg/ml and 18µg/ml respectively. The method was validated for its linearity, precision and accuracy .The proposed method was successfully applied for the determination of guaifenesin in syrups and industrial effluent samples

Multi-Modal, Surface-Focused Anticoagulation Using Poly-2-methoxyethylacrylate Polymer Grafts and Surface Nitric Oxide Release

This study examines platelet adhesion on surfaces that combine coatings to limit protein adsorption along with “anti-platelet” nitric oxide (NO) release. Uncoated and poly-2-methoxyethylacrylate (PMEA) coated, gas permeable polypropylene (PP) membranes were placed in a bioreactor to separate plasma and gas flows. Nitrogen with 100/500/1000 ppm of NO was supplied to the gas side as a proof of concept. On the plasma side, platelet rich plasma (PRP, 1 × 108 cell/mL) was recirculated at low (60)/high (300) flows (mL/min). After 8 hours, adsorbed platelets on PP was quantified via a lactate dehydrogenase assay. Compared to plain PP, the PMEA coating alone reduced adsorption by 17.4 ± 9.2% and 29.6 ± 16.6% at low and high flow (p \u3c 0.05), respectively. NO was more effective at low plasma flow. At 100 and 500 ppm of NO, adsorption fell by 37.9 ± 6.1% and 100 ± 4.7%, (p \u3c 0.001), on plain PP. At high flow with 100, 500, and 1000 ppm of NO, adsorption reduced by 17.9 ± 17.8%, 46.4 ± 23.2%, and 100 ± 4.8%, (p \u3c 0.001), respectively. On PMEA-coated PP with only 100 ppm, adsorption fell by 69.7 ± 6.8 and 65.6% ± 16.9%, (p \u3c 0.001), at low and high flows respectively. Therefore, the combination of an anti-adsorptive coating with NO has great potential to reduce platelet adhesion and coagulation at biomaterial surfaces

Curriculum of the Koran in Drawing the General Educational Landmarks for Children

This research aims to extrapolate the verses of the Koran to guide the educational paths of children, how to develop their talents based on the meanings of these verses, and download them to the reality of the contemporary child in order to formulate his thought and reason, his upbringing in facing life's problems, and contemporary challenges. Because the Qur'an has multiple disciplinary and educational methods, it is a safety station for the creation of a conscious generation, and these are the themes used for this research. Keywords: curriculum, education, children, Quran, milestone

Impacts Power Flow And Quality Of Penetrating 50MW Wind Plant Into Stand Alone Grid

The demand for electricity is continuously growing due to the development in community's macro-economic parameters; Population and the Gross Domestic Product (GDP). Currently, electricity is mainly generated from conventional sources including fossil fuels (oil, coal, gas, etc.) and nuclear fuel. The increase in demand increases the concerns about depletion of fossil fuels, increasing of carbon dioxide (C02) and other emissions, environmental pollution, and climate changes. Global energy agencies have been urged to look for sustainable and environment friend resources. Renewable energy resources especially wind and solar resources are found ambitious sources that can be developed to share other resources in supplying sustainable environmental friend power due to their economic benefits as compared with other resources and technologies. Energy generated from wind is growing faster than other renewable resources especially at areas with proper wind speed and characteristics capable to generate high power at small land and the possibility to interconnect wind networks with distribution or transmission power networks. Predictability of wind availability and characteristics is limited; therefore, the output of wind turbines cannot be controlled to the same extent as conventional generation technologies. This study involves assessing the impact of interconnecting a 50 MW wind plant at different penetration levels into a 132-kV grid powering a region in the sultanate of Oman isolated (islanded) from the main national grid. The assessment includes mutual impacts on power quality and flow, grid voltage flickering and performance of the network and the farm under steady state and disturbance conditions. The wind plant is constructed from an 18-equal capacity DFIG wind turbines modelled using the simulation from MA TLAB/Simulink available in the college. Parameters of control and operation parameters were developed to fit the wind plant operating conditions. The penetration levels considered in the research include I, 9 & 18 wind turbines in operation respectively which represent 5.5 %, 50 % and 100 % of the maximum farm generation capacity. The research outcomes revealed that penetrating the wind plant at the levels mentioned above provide high accuracy of compliance with the national and international standards and codes and that it shall not conflict the requirements of power quality and security of supply restricted in grid code and regulations. The outcomes obtained also provide high degree of confidence for integrating the wind plant with the existing grid network at the proposed point of common connection (PCC) without any additional extra works required on the existing network rather than those required for adaptation requirements

Frequency of Gγ-globin promoter −158 (C>T) XmnI polymorphism in patients with homozygous/compound heterozygous beta thalassaemia

BackgroundResponse to hydroxyurea therapy in homozygous or compound heterozygous beta thalassaemia (BT) has been reported as more favourable in the presence of XmnI polymorphism. The prevalence of XmnI polymorphism may vary with BT phenotypes and genotypes, and differs geographically in distribution. Prevalence of XmnI polymorphism is not known in northern Pakistan.ObjectiveTo determine the frequency of Gγ-globin promoter −158 (C>T) XmnI polymorphism (XmnI polymorphism) in patients with homozygous or compound heterozygous beta thalassaemia.MaterialsPolymerase chain reaction (PCR) for common beta thalassaemia mutations and Gγ-globin promoter −158 (C>T) XmnI polymorphism was performed on 107 blood samples of transfusion dependent beta thalassaemia (BT) patients in Pakistan. One hundred samples of unrelated BT traits and 94 samples of healthy subjects as controls were also analysed for BT mutations and XmnI polymorphism.ResultsOut of 301 DNA samples, XmnI polymorphism was detected in 71(24%); in normal controls, XmnI polymorphism was detected in 34/94 (36%) subjects; while in homozygous/compound heterozygous BT, it was detected in 14/107(13%) patients (Fisher’s exact test, p=.0002). In heterozygous BT group, XmnI polymorphism was detected in 23/100 subjects (Fisher’s exact test, p=.03 with normal controls, and p=.049 with homozygous/compound heterozygous BT). The most common BT genotype was Frame Shift (Fr) 8–9/Fr 8–9, and none of the patients with this genotype had XmnI polymorphism. The second most common genotype was IVSI-5/IVSI-5; 4/26 (15%). Cases with this genotype had XmnI polymorphism.ConclusionXmnI polymorphism in homozygous/compound heterozygous BT group is 13%. The most common genotype associated with XmnI polymorphism was IVSI-5/IVSI-5

Mapping Turbidity Levels in the Lake’s Water using Satellite Remote Sensing Technique

Haleji lake, Thatta, Sindh, has been affected by water pollution in the past decades. This study focuses on mapping water pollution at Haleji lake using turbidity as the pollution indicator. In this study, an algorithm was developed by correlating satellite reflectance data and in-situ turbidity measurements using regression analysis. The determination coefficient R2 of the developed algorithm showed a value of 0.83 that is evidence of a good correlation between field-based and mapped turbidity. Moreover, a temporal analysis was carried out using the same algorithm for the years 1999 and 2011. Results of temporal analysis confirmed that the turbidity levels in Haleji lake have increased from below 5 NTU to around 15 – 30 NTU. This is a clear sign of lake pollution in the interim of the past twelve years

Aggregated Modelling Analysis Of Power Flow From Wind Power Plant Into Grid System Using MATLAB/ SIMULINK Software

In consistent with the growth in demand, complexity of electric power systems has evolved to meet the requirements of supply. Power is generated from non-renewable, fossil fuels and nuclear fuel while renewable energy resources mainly include solar and wind. Power from Wind plants WP has shown a fast growth in the last decades due to their economic benefits especially at areas with the proper wind speed and the possibility to connect wind generators in distribution or transmission power networks. Conventional power unit generators are of high generation capacities, therefore smaller numbers are required in power plant, in other hand wind turbines WP are of smaller capacities therefore, Wind Power Plants (WPPs) consist of dozens or hundreds of low-power units. Time domain simulations of WPPs may take too much time if detailed models are considered in such studies while reduced order models used in interconnection studies of synchronous machines with full converter technology significantly reduce computational time (1, 2). The performance of all models is evaluated based on time domain simulations in the Simulink/MATLAB environment. The work includes the simulation of 50 MW WPP constructed from 18 MW doubly fed induction generators (DFIGs) aggregated (reduced) to one system of Nx2.78 MW generation capacity interconnected to existing conventional system network through 132 kV grid. The analysis includes active and power flow at the farm and the PCC terminals also power flow at PCC has been assessed for different level of WP penetration. Outputs from the MATLAB/SIMULINK modeling and simulation introduces the level of the grid voltage, current active and reactive power in the PCC and the wind farm terminal

Fabrication and In vivo Thrombogenecity Testing of Nitric Oxide Generating Artificial Lungs

Hollow fiber artificial lungs are increasingly being used for long-term applications. However, clot formation limits their use to 1–2 weeks. This study investigated the effect of nitric oxide generating (NOgen) hollow fibers on artificial lung thrombogenicity. Silicone hollow fibers were fabricated to incorporate 50 nm copper particles as a catalyst for NO generation from the blood. Fibers with and without (control) these particles were incorporated into artificial lungs with a 0.1 m2 surface area and inserted in circuits coated tip-to-tip with the NOgen material. Circuits (N = 5/each) were attached to rabbits in a pumpless, arterio-venous configuration and run for 4 h at an activated clotting time of 350–400 s. Three control circuits clotted completely, while none of the NOgen circuits failed. Accordingly, blood flows were significantly higher in the NOgen group (95.9 ± 11.7, p \u3c 0.01) compared to the controls (35.2 ± 19.7; mL/min), and resistance was significantly higher in the control group after 4 h (15.38 ± 9.65, p \u3c 0.001) than in NOgen (0.09 ± 0.03; mmHg/mL/min). On the other hand, platelet counts and plasma fibrinogen concentration expressed as percent of baseline in control group (63.7 ± 5.7%, 77.2 ± 5.6%; p \u3c 0.05) were greater than those in the NOgen group (60.4 ± 5.1%, 63.2 ± 3.7%). Plasma copper levels in the NOgen group were 2.8 times baseline at 4 h (132.8 ± 4.5 μg/dL) and unchanged in the controls. This study demonstrates that NO generating gas exchange fibers could be a potentially effective way to control coagulation inside artificial lungs

Experimental study of the influence of glass cover cooling using evaporative cooling process on the thermal performance of single basin solar still

Acute shortage of drinking water has been on the rise owing to increasing population as well as shortage of drinkable water. Generation of potable water using passive solar stills is among the simplest and easier devices which make use of solar heat energy. However, the output of solar still is generally low owing to greater heat loss and needs improvement. In this paper, an experimental analysis is carried out to determine the performance of passive solar still with glass cover cooling using cold water generated using passive evaporative cooling process. The cold water required for cooling the glass cover is obtained using evaporative cooling process in the water tank which is wound with wet cotton cloth wick. The cold water thus obtained is sprayed onto the top surface of glass cover. The experiment is carried out in the outdoor conditions of Dubai from 10:00h to 14:00h and the temperature recordings of basin plate, glass cover, basin water, ambient air and cooling water are noted for every 30 minutes. The results reveal that the average increase in condensation heat transfer coefficient is found to be about 20.8% higher in the presence of glass cover cooling and the distillate output is found to increase by about 3.32 times. The average still efficiency is found to be relatively higher in the presence of cooling which is about 7.3% higher in the presence of cooling. The cold water temperature generated through evaporative cooling process is about 20.4% lower as compared to ambient temperature. Thus, the cooling of glass cover using cold water obtained through evaporative cooling process is found to be effective in enhancing the thermal performance of single basin solar still system

Operative management and outcomes in patients with myxomas: A single-center experience

BackgroundCardiac myxoma is a rare cardiac tumor that may be asymptomatic or can cause embolization or intracardiac obstruction, leading to heart failure, sudden cardiac death, and arrhythmia. This study aims to report an 11-year experience of a single center in the management of cardiac myxoma.MethodThis study is a single-center retrospective case series. Eighty cases of cardiac myxoma were collected in Ibn Albitar's specialized center for cardiac surgery. Transthoracic echocardiography was used to make the preoperative diagnosis in all patients. The surgeries were undertaken through the standard approach of a median sternotomy. All four cardiac chambers were thoroughly explored for additional myxomas. The major objective of the operations was complete tumor resection.ResultThe mean age of the patients was 46.3 years. Females (67.5%) were predominant over males (32.5%). Shortness of breath was the most common symptom (86.25%). The left atrium was the most affected site (83.75%), followed by the right atrium (13.75%). Coronary artery bypass grafting was required as the secondary or associated intervention in 19 (23.75%) cases. The recurrence rate was 11.25%, with a mortality rate of 3.75%.ConclusionRecurrence and tumor embolism are risks of surgical intervention for myxoma. Good preparation using transthoracic echocardiography as a diagnostic tool and standard median sternotomy to complete resection of the tumors can decrease the rate of recurrence, embolism, and even mortality