Metachronous primary cancers of colon and stomac

Synchronous or metachronous occurrence of esophageal, gastric and colonic cancers is a very rare occurrence, although there are several case reports in literature. A case of a 41 years old man with metachronous cancers of colon and stomach is reported

METACOGNITIVE SELF-CONSCIOUSNESS ABOUT USING DIGITAL LIBRARIES FOR ACADEMIC WRITINGS DURING COVID-19 PANDEMICS

COVID-19 is a highly contagious pandemic that restricted scholars to their homes and reduced academic writings since they could not reach libraries. Metacognitive Self-Consciousness is a metacognitive ability. It pertains to awareness and monitoring of thoughts. The purpose of this study was to explore Metacognitive Self-Consciousness about using digital libraries for academic writings during Covid-19 pandemics. The sampling frame consisted of two types of Ph.D. research scholars of the social sciences enrolled at public sector universities. One of them was already using digital library resources, whereas the others were not using digital library resources. The study sample consisted of forty-eight (48) Ph.D. research scholars. The sample was further divided into two groups called treatment and control groups. Online sessions were arranged on metacognitive self-consciousness about using digital libraries for academic writings for the research scholars of the treatment group. The post-test control group was the design of the study. The data were collected with a metacognitive self-consciousness questionnaire about using digital libraries for academic writings (MSCQ-DL). Means (M), Standard Deviations (SD), and t-tests were employed with SPSS version 24. The results concluded that metacognitive self-consciousness about using digital libraries for academic writings remained significant and enhanced academic writing of research scholars of public sector universities (M = 13.4; SD = 2.5), p =.000 \u3c α =0.005. It is recommended that universities focus on the awareness of research scholars about using digital libraries and arrange mandatory sessions for training. This study may open new doors for scholars, supervisors, and other stakeholders to improve their academic writings

Synthesis, characterization and pharmacological evaluation of mixed ligand-metal complexes containing omeprazole and 8-hydroxyquinoline

Purpose: To synthesize a series of mixed ligand-metal complexes and to evaluate their alkaline phosphatase inhibitory capacities, antioxidant potential and antimicrobial activities.Method: Mixed ligand-metal complexes of Zn (II), Ni (II), Co (II), Cu (II), omeprazole and 8- hydroxyquinoline were synthesized. The ligand-metal complexes were characterized by various physicochemical techniques, including elemental analysis, magnetic susceptibility, scanning electron microscope (SEM), mass spectrometry (EI-MS), ultraviolet-visible (UV-Vis) spectrophotometry, Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H-NMR) and conductance studies. The new compounds were also investigated for their alkaline phosphatase (ALPs) inhibition, 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging and antimicrobial activities.Results: Spectroscopic studies revealed the chemical composition of synthesized compounds as well as the bidentate bonding behavior of the coordinating ligands with metal ions. Conductance measurement suggested that the metal complexes were non-electrolytes. Ni(II) complex exhibited antioxidant activity (30.48 ± 0.32 μM) higher than those of BHT (standard) and other complexes. Stronger inhibition of ALPs by Ni (II) mixed ligand complex compared to the other complexes was evident. The synthesized compounds showed moderate to very good antimicrobial activity against bacterial strains, i.e., Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Actinomyces viscosus, Staphylococcus aureus, Bacillus subtilis; as well as against the fungal strains, Candida albicans, Aspergillus flavus and Aspergillus niger.Conclusion: All the mixed ligand complexes demonstrate higher antioxidant, ALPs-inhibitory and antimicrobial activities than their corresponding ligands. This indicates their therapeutic potential as future drug candidates for the concerned diseases.Keywords: Omeprazole, 8-Hydroxyquinoline, Mixed-ligand complexes, Alkaline phosphatase, Bidentate bonding behavior

Managing the complexity of information flow for construction small and medium-sized enterprises (CSMEs) using system dynamics and collaborative technologies

With the increase in e-commerce and the digitisation of design data and information,the construction sector has become reliant upon IT infrastructure and systems. The design and production process is more complex, more interconnected, and reliant upon greater information mobility, with seamless exchange of data and information in real time. Construction small and medium-sized enterprises (CSMEs), in particular,the speciality contractors, can effectively utilise cost-effective collaboration-enabling technologies, such as cloud computing, to help in the effective transfer of information and data to improve productivity. The system dynamics (SD) approach offers a perspective and tools to enable a better understanding of the dynamics of complex systems. This research focuses upon system dynamics methodology as a modelling and analysis tool in order to understand and identify the key drivers in the absorption of cloud computing for CSMEs. The aim of this paper is to determine how the use of system dynamics (SD) can improve the management of information flow through collaborative technologies leading to improved productivity. The data supporting the use of system dynamics was obtained through a pilot study consisting of questionnaires and interviews from five CSMEs in the UK house-building sector

An assessment of the contemporary threat posed by network worm malware

The cost of a zero-day network worm outbreak has been estimated to be up to US$2.6 billion. Additionally zeroday network worm outbreaks have been observed that spread at a significant pace across the global Internet, with an observed infection level of more than 90 percent of vulnerable hosts within 10 minutes. The threat posed by such fast-spreading malware is therefore significant, particularly given the fact that network operator / administrator intervention is not likely to take effect within the typical epidemiological timescale of such infections. This paper presents a classification of wormable vulnerabilities, demonstrating a method to determine if a vulnerability is wormable, and presents a survey into the cause of the reduction of worm outbreaks in recent years, as well as their viability in the future. It then goes on to explore recent wormable vulnerabilities, and points out the issues with operating system security in relation to techniques used by zero-day worms

Managing information complexity using system dynamics on construction projects

The increase in e-commerce, the digitisation of design data and the interchange and sharing of information have made the construction sector more reliant upon IT infrastructure and systems. The design and production process is complex, dynamic, interconnected and dependent upon greater information mobility, requiring seamless exchange of data and information in real time. Small- and medium-sized enterprises (SMEs), in particular, specialty contractors, can utilise cost-effective collaboration technologies, such as cloud computing using software as a service, to help in the effective transfer of information and data. The system dynamics (SD) approach gives a better understanding of the dynamics of complex systems. SD methodology is used as a modelling and analysis tool to understand and identify the key drivers in the absorption of cloud computing for SMEs. The aim is to determine how the use of SD can improve the management of complexity of information flow, leading to improved performance for SMEs. SD is shown to be a viable tool to manage information complexity using cloud computing for performance improvement in construction

Isolation of squarrosal and squarrosol compounds from methanol root extract of Ruellia squarrosa (Acanthaceae)

Purpose: To identify, characterize and structurally elucidate bioactive compounds from root of Ruellia squarrosa.Methods: One kilogram of crude Ruellia squarrosa root was shade dried for 14 days, ground to a fine powder and subjected to a methanol extraction. The resultant extract underwent column chromatography for further purification. The isolated compounds were subjected to ultraviolet spectroscopy (UV), infra-red (IR), proton nuclear magnetic resonance (1H-NMR), 13C–NMR and high resolution electron ionization mass spectrometry (HR-EI-MS) for the identification, characterization and structural elucidation of bioactive compounds. The most active compounds were tested for anticancer activities against human prostate cancer cell.Results: Two active compounds, squarrosol and squarrosal, were obtained with half-maximal inhibitory concentration (IC50) of 15.6 and 26.6 μg/mL, respectively, against human prostate cancer cell lines. Squarrasol showed a significantly (p < 0.05) greater inhibition of cell proliferation than the same dose of squarrasal.Conclusion: These findings suggest that extracts of Ruellia squarrosa containing the bioactive compounds, squarrosol and squarrosal, can potentially be developed for the treatment of human prostate cancer.Keywords: Ruellia squarrosa, Prostate cancer, Squarrosol, Squarrosal, Anit-proliferativ

Minimally invasive papillary carcinoma of the extrahepatic bile ducts

Invasive papillary carcinomas of the Extrahepatic Bile Ducts (EBD) are uncommon (4-5%). The course is less aggressive than conventional adenocarcinomas of the extrahepatic bile ducts. Non-invasive and minimally invasive papillary carcinomas are even rarer, behave as in-situ carcinomas and are associated with excellent long-term prognosis. A variety of lesions of the EBD that show papillary architecture should be distinguished from papillary carcinoma. Here, we report a case of papillary carcinoma of the common bile duct showing minimal invasion. Separation of invasive from non-invasive or minimally invasive papillary carcinoma is critical in estimating the patient outcome