Road to Ghana: Nkrumah, Southern Africa and the eclipse of a decolonizing Africa

Published versionThis article interrogates the position of Accra as an ‘extra-metropolitan’ centre for southern African anti-colonial nationalists and anti-apartheid activists during the so-called ‘first wave’ of Africa’s decolonization. Drawn to Ghana by a narrative of decolonization and continental pan-Africanism that was at once peaceful and revolutionary, southern African ‘Freedom Fighters’ and expatriates first traveled to the Ghanaian capital of Accra in anticipation of the 1958 All-African Peoples Conference. Inside Ghana, southern African parties including the ANC and NDP and later the PAC, ZAPU and ZANU worked with the government of Kwame Nkrumah’s Convention People’s Party (CPP) in establishing an anti-colonial policy that spoke both to the unique settler situation in the region and the heightening international tensions of the emergent Cold War – a transnational dialogue to which the Nkrumah administration was not always receptive. As such, this article argues that the southern African presence in Accra and the realities of settler rule in the region challenged Nkrumah’s and others’ faith in the ‘Ghanaian’ model of decolonization, thus leading to a radicalization of African anti-colonial politics in Ghana during the early and mid-1960s as Nkrumahand his allies faced the prospect of the continent’s ‘failed’ decolonization.Department of HE and Training approved lis

Accumulation of natural killer cells after hepatic artery embolisation in the midgut carcinoid syndrome.

Eleven patients with disseminated midgut carcinoid tumour disease were subjected to hepatic artery embolisation. In six patients, lymphocytosis with a predominance of NK cells occurred and the cytotoxic activity of isolated lymphocytes increased. A relation between NK cell accumulation and subsequent radiological and biochemical response was observed, and it is suggested that anti-tumour mechanisms other than ischaemia may contribute to the therapeutic response in these patients

Education Through Labor: From the deuxième portion du contingent to the Youth Civic Service in West Africa (Senegal/Mali, 1920s-1960s)

International audienceUnder the French colonial regime, the “second portion” of the military was used as labour brigades, compelled to serve for two years in works of public nature. They were encamped in labor camp and were taught the value of work as well as discipline and basic rules of hygiene. After the independence of the francophone West African countries in 1960, postcolonial leaders in Senegal and Mali try to implement a civil service for the youth in order to offer them basic education. In reality, the civil service appears as a way to control and use the recruits for economic purposes echoing in some extent the former colonial “second portion du contingent.” More broadly, through the analysis of the legacies and continuities, I argue that the postcolonial elites perpetuate the “civilizing mission,” no more for the so-called mise en valeur of the colonies but for the development of the territory

Adjuvant imatinib treatment improves recurrence-free survival in patients with high-risk gastrointestinal stromal tumours (GIST)

Palliative imatinib treatment has dramatically improved survival in patients with malignant gastrointestinal stromal tumours, particularly in patients with tumours harbouring activating KIT mutations. To evaluate the effectiveness of adjuvant imatinib after radical surgery, a consecutive series of patients with high-risk tumours (n=23) was compared with historic controls (n=48) who were treated with surgery alone. The mean follow-up period was over 3 years in both groups. Only 1 out of 23 patients (4%) in the adjuvant treatment group developed recurrent disease compared to 32 out of 48 patients (67%) in the control group. This preliminary study indicates that 1 year of adjuvant treatment with imatinib dramatically improves recurrence-free survival. Confirmation of these findings awaits the results of ongoing randomised studies

Reducing uncertainty in health-care resource allocation

A key task for health policymakers is to optimise the outcome of health care interventions. The pricing of a new generation of cancer drugs, in combination with limited health care resources, has highlighted the need for improved methodology to estimate outcomes of different treatment options. Here we introduce new general methodology, which for the first time employs continuous hazard functions for analysis of survival data. Access to continuous hazard functions allows more precise estimations of survival outcomes for different treatment options. We illustrate the methodology by calculating outcomes for adjuvant treatment of gastrointestinal stromal tumours with imatinib mesylate, which selectively inhibits the activity of a cancer-causing enzyme and is a hallmark representative for the new generation of cancer drugs. The calculations reveal that optimal drug pricing can generate all win situations that improve drug availability to patients, make the most of public expenditure on drugs and increase pharmaceutical company gross profits. The use of continuous hazard functions for analysis of survival data may reduce uncertainty in health care resource allocation, and the methodology can be used for drug price negotiations and to investigate health care intervention thresholds. Health policy makers, pharmaceutical industry, reimbursement authorities and insurance companies, as well as clinicians and patient organisations, should find the methodology useful