Survey Paper on Pattern-Enhanced Topic Model for Data Filtering

The machine learning & text mining area topic modeling has been extensively accepted etc. To generate statistical model to classify various topics in a collection of documents topic modelling was proposed. A elementary presumption for those approaches is that the documents in the collection are all about one topic. To represent number of topics in a collection of documents, Latent Dirichlet Allocation (LDA) topic modelling technique was proposed, it is also used in the fields of information retrieval. But its effectiveness in information filtering has not been well evaluated. Patterns are usually thought to be more discriminating than single terms for demonstrating documents. To discovered pattern become crucial when selection of the most representative and discriminating patterns from the huge amount. To overcome limitations and problems, a new information model approach is proposed. Proposed model includes user information important to generate in terms of various topics where each topic is represented by patterns. Patterns are generated from topic models and are organized in terms of their statistical and taxonomic features and the most discriminating and representative patterns are proposed to estimate the document relevant to the user?s information needs in order to filter out irrelevant documents. To access the propose model TREC data collection and Reuters Corpus vol. 1 are used for performanc

To Study The Indications And Outcome Of Caesarean Section At A Tertiary Health Facility Located In A Rural Setting.

Background: Caesarean section (CS) is a common surgical procedure performed in women of reproductive age. The numerous indications for a CS may be due to fetal or maternal problems. Though it is a life saving procedure, it also carries a higher morbidity and mortality than vagina delivery.Method: This is a retrospective study conducted from January 2014 to December 2014 at a secondary health facility located in a rural setting in Ahmednagar. The theatre registers were the sources of data.Results: There were fourteen indications for the 731-caeserean sections performed with previous LSCS beingThe highest indication. Previous LSCS, Fetal distress, CPD and Oligohydromnios were the major indications for caesareanSection. There were 1 maternal death and 4 stillbirths out of the 731 babies delivered.Conclusion: Changing trends and changing indications are very well can be seen from the study suggesting that “Once a cesarean always a cesarean†is what we seem to achieve in near future

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AZILSARTAN MEDOXOMIL AND CHLORTHALIDONE IN BULK AND TABLET DOSAGE FORM

Objective: A simple, precise, accurate method was developed for the simultaneous estimation of azilsartan and chlorthalidone in bulk and tablet dosage form by RP-HPLC technique.Methods: Acetonitrile and water in the ratio of (70:30) pH 2.8 used as mobile phase run through (Cosmosil C18 (4.6ID x 250 mm, Particle size: 5 micron) column with a flow rate of 0.9 ml/min. The temperature of the column oven was maintained at 30 °C. Wavelength was selected 244 nm. Stock and working solutions were prepared by using the diluents water and acetonitrile in the ratio of 50:50. Runtime was fixed to 9 min.Results: Chlorthalidone and azilsartan were eluted at 2.02 and 3.92 with good resolution the plate count, tailing factor and all system suitability parameters are within ICH range. Azilsartan Medoxomil and Chlorthalidone were found to be linear low in concentration range of 80-400μg/ ml and 25-125μg/ ml respectively in the linearity study, regression equation and coefficient of correlation for Azilsartan Medoxomil and Chlorthalidone were found to be (y = 28695x+15397 r²=0.995) and (y=13444+27405 r² = 0.996) Percentage recovery for both Azilsartan Medoxomil and Chlorthalidone was found in range of 99.89%-99.96% indicating accuracy of the proposed work. Assay of the tablet was performed and found as 100.15%.Conclusion: All the parameters were within the ICH guidelines, and the method was economical and simple as retention times were less than in literature and decreased run time

Myoinositol with Metformin and Myoinositol alone in infertile PCOS women undergoing ovulation induction cycles: A comparative study

Background: This was a prospective observational study conducted over a twelve-month duration in our institute to compare the combined effect of metformin and myoinositol with metformin alone. Method: A total of sixty patients were included in the study, and they were divided into two groups depending on whether they were given the combination or the single drug. Group A (n=30) was given Myoinositol 600 mg+Metformin 500 mg thrice a day, and Group B ( n=30) was given only Myoinositol 600 mg thrice a day. The outcome measure was clinical pregnancy rate and improvement in clinical and hormonal parameters after drug therapy. Results: BMI (p<0.01), modified Ferriman Gallaway score (p>0.05), and the was a significant improvement in the hormonal parameters (LH,FSH) in both the groups and the levels were found to be comparable after a period of 6 months. The clinical pregnancy rate after six cycles of ovulation was significantly higher in Group A as compared to Group B. In Group A, the total clinical pregnancy rate was 43.33%, and in Group B, it was 26.67%, respectively, and the end of 6 months and the difference was statistically significant (p = <0.01) Conclusion: Equal response in reduction of hormonal levels and clinical and laboratory parameters were seen in both groups, while better results in terms of clinical fertility rates were observed in the group that was given a combination of myoinositol with metformin

Prioritization of watersheds using multi-criteria evaluation through fuzzy analytical hierarchy process

Conservation of available natural resources through demarcation of potential zones at micro level are primary necessitate for sustainable development, particularly in the fragile semi-arid tropics.  Delineation of potential zones for implementation of conservation measures above the entire watershed at similar occurrence is inaccessible as well as uneconomical; consequently it is a prerequisite to apply viable technique for prioritization of sub-watersheds (SWDs).  Keeping this in view, the present research attempted to study various morphological characteristics and to implement Geographical Information System (GIS) and Multi Criteria Decision Making (MCDM) through Fuzzy Analytical Hierarchy Process (FAHP) techniques for identification of critical sub-watersheds situated in transaction zone between mountainous and water scarcity region of Western Part of India.  The morphometric characterization was obtained through the measurement of three distinct linear, areal and relief aspects over the eight sub-watersheds.  The morphometric characterization showed imperative role in distinguishing the topographical and hydrological behavior of the watershed.  Each hydrological unit was ranked with respect to the value and weightages obtained by deriving the relationships between the morphometric parameters obtained through classification of the SWDs by associating the robustness of fuzzy logic and the Analytical Hierarchy Processes (AHP).  Based on FAHP approach, sub-watersheds were evaluated as vulnerability assessment zones and alienated into five prioritization levels: very less, less, medium, high and very high classes.  The evaluated results illustrated that 60.85% of sub-watersheds (five sub-watersheds) were in the medium to high susceptible zones, which depicted potential areas for necessity of establishment of conservation interventions for the sustainable watershed management planning.  The FAHP based technique is a viable approach in illustrating the dilemma particularly over data hungry and complex conventional soil and water risk assessment methods and will be useful to various stakeholders (rural extension community, agriculturists and water resources managers) for better decision making with an obliging rule based system for implementing various assessment measures.   Keywords: fuzzy analytical hierarchy process, geographic information system, multiple criteria decision making, watershed prioritizatio

Myoinositol with Metformin and Myoinositol alone in infertile PCOS women undergoing ovulation induction cycles: A comparative study

Background: This was a prospective observational study conducted over a twelve-month duration in our institute to compare the combined effect of metformin and myoinositol with metformin alone. Method: A total of sixty patients were included in the study, and they were divided into two groups depending on whether they were given the combination or the single drug. Group A (n=30) was given Myoinositol 600 mg+Metformin 500 mg thrice a day, and Group B ( n=30) was given only Myoinositol 600 mg thrice a day. The outcome measure was clinical pregnancy rate and improvement in clinical and hormonal parameters after drug therapy. Results: BMI (p<0.01), modified Ferriman Gallaway score (p>0.05), and the was a significant improvement in the hormonal parameters (LH,FSH) in both the groups and the levels were found to be comparable after a period of 6 months. The clinical pregnancy rate after six cycles of ovulation was significantly higher in Group A as compared to Group B. In Group A, the total clinical pregnancy rate was 43.33%, and in Group B, it was 26.67%, respectively, and the end of 6 months and the difference was statistically significant (p = <0.01) Conclusion: Equal response in reduction of hormonal levels and clinical and laboratory parameters were seen in both groups, while better results in terms of clinical fertility rates were observed in the group that was given a combination of myoinositol with metformin

REVIEW: FAST DISSOLVING TABLET

Fast dissolving tablets is one of the most widely accepted dosage forms and also most popular dosage form, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson's disorder or hand tremors. Some solid dosage forms like tablets and capsules are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitations like the first-pass metabolism. Fast dissolving tablets are one of them. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. Some tablets are designed to dissolve fastly in saliva, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate

Evaluation of Tribological Properties of Transesterified Cottonseed Oil by Adding Silicon Dioxide (SiO2) as an Additive

The usage of vegetable oils has increased in many applications as they possess desirable lubrication properties. However, the use is limited due to poor tribological properties. Many researchers have attempted to explore the performance of various vegetable oils and the effect of adding anti-wear additives on tribological properties. In the present work, bio lubricant is obtained from pure cottonseed oil (CSO). Silicon Dioxide, a useful catalyst, is used as an anti-wear additive. Oleic Acid surface-modified Silicon Dioxide (OA-SiO2) is added at 0.25%, 0.5%, 0.75%, and 1% weight concentrations in transesterified cottonseed oil (TCSO). After the addition of OA-SiO2 nanoparticles, the improvement in the lubrication properties has been seen. A four-ball tester is used to measure the coefficient of friction (COF) and wear scar diameter (WSD) of CSO, TCSO, and additive-added TCSO as per ASTM standard D 4172. Friction and wear tests reveal that the TCSO with OA-SiO2 nanoparticles shows better tribological properties. It is observed that WSD and COF of TCSO are reduced by 11.85 % and 24.88 % respectively by adding 0.75 weight % of OA-SiO2 nanoparticles. Present work shows that TCSO, on adding OA-SiO2 additives, can be a strong alternative for mineral oil

A REVIEW: FILM FORMING GEL NOVEL DRUG DELIVERY SYSTEM

Film forming gels are a novel approach in this area that might present an alternative to the conventional dosage forms used on the skin, such as ointments, creams, gels or patches. The polymeric solution is applied to the skin as a liquid and forms an almost invisible film in situ by solvent evaporation. Transdermal drug delivery system (TDDS) and dermal drug delivery system can provide some desirable performances over conventional pharmaceutical dosage formulations, such as avoiding gut and hepatic first-pass metabolism, improving drug bioavailability, reducing dose frequency and stabilizing drug delivery profiles. The aim of this review was to search for alternatives to the conventional forms in order to reduce skin irritation, improve skin adhesion properties, enhance the drug release and increase the patient acceptability from an aesthetic perspective. Because of their peculiar rheological behaviour, polymeric gels are beneficial in terms of ease of preparation, ease of application, adhesion to the application surface and ability to deliver a wide variety of drugs