Self-Regulatory Behavior of Adolescent Students in Ethiopia –The Case of Ayer Tena High School, Kolfe Keranio Sub City, Addis Ababa, Ethiopia

Self-regulatory behavior is an important personal skill that strengthens in the course of transition from childhood to adulthood. While self-regulation promotes healthy and successful transitioning to adulthood, deficiency in self-regulation would expose the growing persons to a host of undesirable behaviors including impulsivity, violence, health risky behaviors etc. The aim of this study was to examine adolescents. self-regulatory behavior and how it was associated with parental involvement and such other background factors as age, gender, family structure, and socio-economic status. A total of 211 secondary school adolescent students were selected as data sources. Socio-Economic Status Inventory, Self-Regulation Scale and Parental Involvement Scale were employed for data collection. Findings indicated that the level of self-regulatory behavior was significantly higher among the adolescents. The same pattern was exhibited in all the three dimensions of self-regulation. While sex and parental involvement were found to have significant relationship with self-regulatory behavior, age, socio-economic status, fathers. educational level, and family structure were, however, minimally correlated. Discussing the findings against a backdrop, basically of, socio-cultural reality of the study setting, further research was suggested to unveil this context of self-regulation using mixed research design

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

Background: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce deaths from intracranial bleeding after traumatic brain injury (TBI). To explore the mechanism of action of TXA in TBI, we examined the timing of its effect on death. Methods: The CRASH-3 trial randomised 9202 patients within 3 h of injury with a GCS score ≤ 12 or intracranial bleeding on CT scan and no significant extracranial bleeding to receive TXA or placebo. We conducted an exploratory analysis of the effects of TXA on all-cause mortality within 24 h of injury and within 28 days, excluding patients with a GCS score of 3 or bilateral unreactive pupils, stratified by severity and country income. We pool data from the CRASH-2 and CRASH-3 trials in a one-step fixed effects individual patient data meta-analysis. Results: There were 7637 patients for analysis after excluding patients with a GCS score of 3 or bilateral unreactive pupils. Of 1112 deaths, 23.3% were within 24 h of injury (early deaths). The risk of early death was reduced with TXA (112 (2.9%) TXA group vs 147 (3.9%) placebo group; risk ratio [RR] RR 0.74, 95% CI 0.58–0.94). There was no evidence of heterogeneity by severity (p = 0.64) or country income (p = 0.68). The risk of death beyond 24 h of injury was similar in the TXA and placebo groups (432 (11.5%) TXA group vs 421 (11.7%) placebo group; RR 0.98, 95% CI 0.69–1.12). The risk of death at 28 days was 14.0% in the TXA group versus 15.1% in the placebo group (544 vs 568 events; RR 0.93, 95% CI 0.83–1.03). When the CRASH-2 and CRASH-3 trial data were pooled, TXA reduced early death (RR 0.78, 95% CI 0.70–0.87) and death within 28 days (RR 0.88, 95% CI 0.82–0.94). Conclusions: Tranexamic acid reduces early deaths in non-moribund TBI patients regardless of TBI severity or country income. The effect of tranexamic acid in patients with isolated TBI is similar to that in polytrauma. Treatment is safe and even severely injured patients appear to benefit when treated soon after injury. Trial registration: ISRCTN15088122, registered on 19 July 2011; NCT01402882, registered on 26 July 2011