Resilience of the Spectral Standard Model

We show that the inconsistency between the spectral Standard Model and the experimental value of the Higgs mass is resolved by the presence of a real scalar field strongly coupled to the Higgs field. This scalar field was already present in the spectral model and we wrongly neglected it in our previous computations. It was shown recently by several authors, independently of the spectral approach, that such a strongly coupled scalar field stabilizes the Standard Model up to unification scale in spite of the low value of the Higgs mass. In this letter we show that the noncommutative neutral singlet modifies substantially the RG analysis, invalidates our previous prediction of Higgs mass in the range 160--180 Gev, and restores the consistency of the noncommutative geometric model with the low Higgs mass.Comment: 13 pages, more contours added to Higgs mass plot, one reference adde

Personalization framework for adaptive robotic feeding assistance

The final publication is available at link.springer.comThe deployment of robots at home must involve robots with pre-defined skills and the capability of personalizing their behavior by non-expert users. A framework to tackle this personalization is presented and applied to an automatic feeding task. The personalization involves the caregiver providing several examples of feeding using Learning-by- Demostration, and a ProMP formalism to compute an overall trajectory and the variance along the path. Experiments show the validity of the approach in generating different feeding motions to adapt to user’s preferences, automatically extracting the relevant task parameters. The importance of the nature of the demonstrations is also assessed, and two training strategies are compared. © Springer International Publishing AG 2016.Peer ReviewedPostprint (author's final draft

Conserved Central Intraviral Protein Interactome of the Herpesviridae Family

Protein interactions are major driving forces behind the functional phenotypes of biological processes. As such, evolutionary footprints are reflected in system-level collections of protein-protein interactions (PPIs), i.e., protein interactomes. We conducted a comparative analysis of intraviral protein interactomes for representative species of each of the three subfamilies of herpesviruses (herpes simplex virus 1, human cytomegalovirus, and Epstein-Barr virus), which are highly prevalent etiologic agents of important human diseases. The intraviral interactomes were reconstructed by combining experimentally supported and computationally predicted protein-protein interactions. Using cross-species network comparison, we then identified family-wise conserved interactions and protein complexes, which we defined as a herpesviral “central” intraviral protein interactome. A large number of widely accepted conserved herpesviral protein complexes are present in this central intraviral interactome, encouragingly supporting the biological coherence of our results. Importantly, these protein complexes represent most, if not all, of the essential steps required during a productive life cycle. Hence the central intraviral protein interactome could plausibly represent a minimal infectious interactome of the herpesvirus family across a variety of hosts. Our data, which have been integrated into our herpesvirus interactomics database, HVint2.0, could assist in creating comprehensive system-level computational models of this viral lineage

Role of hypoxia inducible factor HIF-1α in heart valves

The 2016 Albert Lasker Basic Medical Research Award and subsequently the 2019 Nobel Prize in Physiology or Medicine were awarded to William Kaelin, Jr., Sir Peter Ratcliffe, and Gregg Semenza for their work on how cells sense and adapt to hypoxic conditions. Their work showed that the changes in gene expression, cell metabolism, and tissue remodelling that occur in response to low oxygen concentrations are orchestrated by the transcription factor, hypoxia inducible factor-1α (HIF-1α). While the effects mediated by HIF-1α have been widely studied, its role in heart valves has only recently been investigated. These studies have shown that HIF-1α expression is evident in mechanisms that regulate the structure and function of heart valves. These include embryonic development, the regulation of the extracellular matrix, angiogenesis and the initiation of the calcification process. This review provides a background on the role and function of HIF-1α in response to hypoxia and a discussion of the available evidence of its involvement in the regulation of heart valves in health and disease

Return to driving after traumatic brain injury : a British perspective

Primary Objective: to identify current legal situation, and professional practice in assisting persons with traumatic brain injury (TBI) to return to safe driving after injury. Methods and Procedures A brief review of relevant literature, a description of the current statutory and quasi-statutory authorities regulating return to driving after TBI in the UK, and a description of the nature and resolution of clinical and practical dilemmas facing professionals helping return to safe driving after TBI. Each of the 15 UK mobility centres was contacted and literature requested; in addition a representative of each centre responded to a structured telephone survey. Main Outcome and Results: The current situation in Great Britain is described, with a brief analysis of the strengths and weaknesses both of the current statutory situation, and also the practical situation (driving centres), with suggestions for improvements in practice. Conclusion Although brain injury may cause serious limitations in driving ability, previous drivers are not routinely assessed or advised regarding return to driving after TBI

Peningkatan Aktivitas Murid Dalam Pembelajaran Tematik Menggunakan Media Realistik Di Kelas III SD

The problem in this research is an attempt to improve the learners\u27 learning activities by using realistic media in thematic learning at the third grade students in the Elementary School 08 Segedong Pontianak. This research method is descriptive, in classroom action research, and the nature of this research is qualitative research, the research subjects are teacher and learners elementary school fourth grade students in the Elementary School 08 Segedong Pontianak which consisted of 24 people in whole. The techniques used in this research were the technique of direct observation, documentary technique, and data collection tool were used as observation guidelines. The result based on observation by using realistic media had improved learners\u27 learning activities. This shows that the hypothesis that stated the application realistic media in thematic learning at the third grade in the Elementary School 08 Segedong Pontianak can improve learners\u27 learning activities, accepted

Peningkatan Aktivitas Peserta Didik Pembelajaran Matematika Menggunakan Metode Pemecahan Masalah di Kelas IV

Implementationof this research effort to improve the learners' learning activities using the method of problem solving in mathematics teaching fourth grade Elementary Shcool 07 River Pinyuh Pontianak. This research method is descriptive method, a form of research that is action research (PTK), the nature of qualitative research, research subjects that teachers and leaners Elementary School fourth grade 07 Pinyuh Pontianak River totaling 26 people. The purpose of this study is to obtain information and clarity about the actual increase in the activity of leaners in learning of mathematics by using problem-solving method in class IV Elementary school 07 River Pinyuh Pontianak. From the results of this study concluded: 1) the physical activity of students in the base line was 23,07% and second cycle was 85,25% in creased by 62,18% in the high category, 2) the mental activity students in the base line by 12,17% and scond cycle was 82,99% increased by 70,82% in the high category, 3) emotional activity learners 32,04% on the base line and the second cycle was 92,30% increased by 60,26% the high category

Korelasi Kemampuan Membaca Pemahaman dengan Menulis Karangan Narasi

The aim of this research is to describe the correlation between comprehension reading ability with writing ability a narrative essay in Indonesian learning at grade VA SDN 39 Sungai Kakap. This research used descriptive method and the type of the research is interrelationship studies. The sample of the research is 27 students. Based on statistical calculations comprehension reading ability include the sufficient category is 1676.32 or the average is 62.09. Writing ability a narrative essays include the sufficient category is 1783.35 or the average is 66.05. Correlation between comprehension reading ability whit writing ability a narrative essay is 0.67 and r xy > r table (0.67 > 0.396) is high category. That means occur a correlation between comprehension reading ability and writing ability a narrative essay in Indonesian learning at grade VA SDN 39 Sungai Kakap

Commensurate 4a04a_0 period Charge Density Modulations throughout the Bi2Sr2CaCu2O8+xBi_2Sr_2CaCu_2O_{8+x} Pseudogap Regime

Theories based upon strong real space (r-space) electron electron interactions have long predicted that unidirectional charge density modulations (CDM) with four unit cell (4$a_0$) periodicity should occur in the hole doped cuprate Mott insulator (MI). Experimentally, however, increasing the hole density p is reported to cause the conventionally defined wavevector $Q_A$ of the CDM to evolve continuously as if driven primarily by momentum space (k-space) effects. Here we introduce phase resolved electronic structure visualization for determination of the cuprate CDM wavevector. Remarkably, this new technique reveals a virtually doping independent locking of the local CDM wavevector at $|Q_0|=2\pi/4a_0$ throughout the underdoped phase diagram of the canonical cuprate $Bi_2Sr_2CaCu_2O_8$. These observations have significant fundamental consequences because they are orthogonal to a k-space (Fermi surface) based picture of the cuprate CDM but are consistent with strong coupling r-space based theories. Our findings imply that it is the latter that provide the intrinsic organizational principle for the cuprate CDM state

Topological Defects Coupling Smectic Modulations to Intra-unit-cell Nematicity in Cuprate

We study the coexisting smectic modulations and intra-unit-cell nematicity in the pseudogap states of underdoped Bi2Sr2CaCu2O8+{\delta}. By visualizing their spatial components separately, we identified 2\pi topological defects throughout the phase-fluctuating smectic states. Imaging the locations of large numbers of these topological defects simultaneously with the fluctuations in the intra-unit-cell nematicity revealed strong empirical evidence for a coupling between them. From these observations, we propose a Ginzburg-Landau functional describing this coupling and demonstrate how it can explain the coexistence of the smectic and intra-unit-cell broken symmetries and also correctly predict their interplay at the atomic scale. This theoretical perspective can lead to unraveling the complexities of the phase diagram of cuprate high-critical-temperature superconductors