Tools to improve palliative care: e-prescription and Patient’s Internet Account — legal status analysis

The implementation of new technology is a response to the challenges of the current health system,such as ageing population and rising treatment costs. Focusing on improving the quality of the servicesprovided and increasing access to treatment guarantees a feeling of safety in the therapeutic process.Amendments introduced to the law and implementing the idea of digitisation of the health care systemmay turn out to be significantly beneficial for both the medical personnel and the relatives taking care ofthe patients. New solutions can be applied by Home Hospices, whose functioning is a significant challengefor organizational and financial reasons.The aim of this paper was to analyse current legal regulations governing electronic prescribing. In addition,the impact of e-prescription and related eHealth elements on the availability and quality of palliative careservices was assessed. Modern information and communications technology can solve many problemsrelated to access, quality and cost-effectiveness of medical services, in particular those concerning palliativecare. E-prescription is a tool that can significantly improve patient care through simplified prescribingrules. New rules for issuing and confirming orders for medical devices also make it much easier for carers

Medicinal product and dietary supplement as waste - legal issues

The issue of waste is a topic widely discussed at both European and national levels. The insufficient share of separately collected waste in the stream and the too large amount of waste sent to landfills, combined with the need for Poland to implement the concept of a circular economy, makes it necessary to analyze the possibility of making changes, primarily in the legal area. Their goal should be to minimize the amount of waste generated and to more effectively counteract the threats resulting from the presence of waste in the environment. Waste of a special nature are medicinal products generated both in pharmacies and households. Improper handling of unnecessary/expired medicinal products may cause negative effects on both the environment and human health. This problem also applies to dietary supplements, which are treated as food products under the law, even though they may contain compounds that may have a negative impact on health and on the environment. Proper handling of waste from medicinal products and dietary supplements depends on the correct classification of these types of waste. The aim of the work is to analyze the regulations regarding the classification of waste from medicinal products (both generated in pharmacies and households) and dietary supplements, as well as legal problems related to this classification. First of all, the classification of waste resulting from dietary supplements is controversial. This is important because correct categorization determines the appropriate, safe method of waste disposal (thermal transformation, storage in landfills). The work also points to problems in defining concepts at the intersection of environmental protection regulations and regulations relating to medicinal products. The analysis was limited to waste from medicinal products and dietary supplements generated in pharmacies and households and does not apply to waste from pharmaceutical plants and chemicals used in pharmacies to produce prescription and pharmaceutical drugs

Metody fizykalne w terapii odleżyn = Physical methods for the treatment of bedsores

Radzimińska Agnieszka, Stettler Dorota, Weber-Rajek Magdalena, Zimmermann Agnieszka Anna, Sowała Krzysztof, Goch Aleksander, Zukow Walery. Metody fizykalne w terapii odleżyn = Physical methods for the treatment of bedsores. Journal of Education, Health and Sport. 2015;5(4):405-414. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.38244http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%284%29%3A405-414https://pbn.nauka.gov.pl/works/685685Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 25.03.2015. Revised 05.04.2015. Accepted: 26.04.2015. Metody fizykalne w terapii odleżynPhysical methods for the treatment of bedsores Agnieszka Radzimińska1, Dorota Stettler2, Magdalena Weber-Rajek1, Agnieszka Anna Zimmermann3, Krzysztof Sowała4, Aleksander Goch1, Walery Zukow5 1.      Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy, Katedra Fizjoterapii, Bydgoszcz, Polska2.      Bydgoska Szkoła Wyższa, Bydgoszcz, Polska3.      Wyższa Szkoła Gospodarki, Bydgoszcz, Polska4.      Szpital Polski, Sztum, Polska5.      Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Bydgoszcz, Polska Adres do korespondencji:dr n. med. Agnieszka RadzimińskaUniwersytet Mikołaja Kopernika w ToruniuCollegium Medicum im. Ludwika Rydygiera w BydgoszczyKatedra Fizjoterapiiul. Marii Skłodowskiej-Curie 9, 85-094 Bydgoszcze-mail: [email protected] StreszczenieOdleżyny (obok zakażeń szpitalnych) to najpoważniejsze powikłania występujące u pacjentów hospitalizowanych. Od lat poszukuje się najskuteczniejszych metod leczenia zachowawczego odleżyn. Wśród tych metod należy zwrócić uwagę na metody leczenia fizykalnego, a wśród nich: fototerapię, elektroterapię, magnetoterapię i sonoterapię.  SummaryPressure ulcers (next to nosocomial infections) are the most serious complications occurring in hospitalized patients. For years he sought the most effective methods of conservative treatment of pressure ulcers. Among these methods, you must pay attention to the methods of physical treatment, among them: phototherapy, electrotherapy, magnetic fields and sonotherapy. Słowa kluczowe: metody fizykalne; terapia; odleżyny.Keywords: physical methods; therapy; bedsores

Jałowe martwice kości, charakterystyka choroby i postępowanie fizykalne – przegląd literatury = Sterile necrosis of bone, the characteristics of the illness and physical examination - a literature review

Radzimińska Agnieszka, Zimmermann Agnieszka Anna, Weber-Rajek Magdalena, Strojek Katarzyna, Bułatowicz Irena, Goch Aleksander, Zukow Walery. Jałowe martwice kości, charakterystyka choroby i postępowanie fizykalne – przegląd literatury = Sterile necrosis of bone, the characteristics of the illness and physical examination - a literature review. Journal of Education, Health and Sport. 2015;5(10):108-120. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.32518http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2810%29%3A108-120https://pbn.nauka.gov.pl/works/660102Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 05.08.2015. Revised 05.09.2015. Accepted: 20.10.2015. Jałowe martwice kości, charakterystyka choroby i postępowanie fizykalne – przegląd literaturySterile necrosis of bone, the characteristics of the illness and physical examination - a literature reviewAgnieszka Radzimińska1, Agnieszka Anna Zimmermann2, Magdalena Weber-Rajek1, Katarzyna Strojek1, Irena Bułatowicz1, Aleksander Goch1, Walery Zukow31.      Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum w Bydgoszczy, Katedra Fizjoterapii, Bydgoszcz, Polska2.      Wyższa Szkoła Gospodarki, Bydgoszcz, Polska3.      Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Bydgoszcz, Polska StreszczenieJałowe martwice kości stanowią zespół chorobowy cechujący się obumieraniem tkanki kostnej oraz tkanki chrzęstnej bez udziału chorobotwórczych drobnoustrojów. Schorzenie to występuje często w nasadach rosnących kości dzieci i młodzieży i jest konsekwencją braku połączeń pomiędzy naczyniami nasad i przynasad kości (brak krążenia obocznego) w okresie wzrostu. Do najczęstszych postaci tej choroby zaliczamy: chorobę Perthesa (martwica typu Legga-Calvégo-Perthesa), chorobę Osgooda-Schlattera, chorobę Freiberga-Köhlera II, chorobę Köhlera I, chorobę Haglunda, chorobę Scheuermanna. Etiologia choroby nie jest znana. Celem niniejszej pracy jest przegląd literatury dotyczącej charakterystyki poszczególnych postaci jałowych martwic kości oraz postępowania fizykalnego w różnych postaciach tej choroby. Abstract Avascular necrosis constitute a syndrome characterized by the withering away of bone tissue and cartilaginous tissue without the participation of pathogenic microorganisms. This disease often occurs in the roots of the growing bones of children and young people and is a consequence of the lack of connection between vessels and the metaphyseal bone epiphysis (lack of collateral circulation) during growth. The most common form of the disease include: Perthes disease (Legg-Calve-Perthes disease), Osgood-Schlatter disease, Freiberg-Köhler disease II, Köhler disease I, Haglund's disease, Scheuermann's disease. The etiology of the disease is not known. The aim of this article is review the literature on the characteristics of each form of aseptic osteonecrosis and physiotherapy in various forms of the disease. Słowa kluczowe: jałowe martwice kości, postępowanie fizykalne.Key word: sterile necrosis of bone, physical examination

Prawo pacjenta do leczenia bólu

The article describes a new (in force since May 2017) right of Polish patients — the right to pain treat­ment. It is an analysis referring to regulations to do with access to pain treatment in inpatient, outpatient and home care. The deliberations on the problem of the right to pain treatment are based on Polish and international regulations as well as the available case law. The authors focus on the access to medicinal products containing drugs since the fear of the possible development of addiction during the use of opioid analgesia is one of the barriers to proper pain treatment.Artykuł opisuje nowe (obowiązujące od maja 2017 r.) uprawnienie polskich pacjentów – prawo do leczenia bólu. Stanowi analizę odwołującą się do uregulowań prawnych związanych z dostępem do terapii przeciwbólowej w opiece stacjonarnej, ambulatoryjnej i domowej. Podstawę rozważań nad problemem prawa do leczenia bólu stanowią regulacje prawa polskiego oraz międzynarodowego a także dostępne orzecznictwo. Autorzy skupiają się na dostępie do produktów leczniczych zawierających w swym składzie środki odurzające ponieważ jedną z przeszkód we właściwym łagodzeniu bólu jest obawa dotycząca możliwości uzależnienia podczas korzystania z analgezji opioidowej

Nationales Referenzzentrum für Masern, Mumps, Röteln - Tätigkeitsbericht für das Jahr 2022

Im NRZ MMR werden Proben von Masern-, Mumps- und Rötelnverdachtsfällen mit dem Ziel der molekularen Charakterisierung der aktuell zirkulierenden Viren untersucht. Für Masern und Röteln werden auf Basis der Ergebnisse der molekularen Surveillance Einschätzungen zum Stand des Eliminationsprogramms der WHO erarbeitet. Im Jahr 2022 sank aufgrund der Maßnahmen zur Bekämpfung der SARS-CoV2-Pandemie die Anzahl der gemeldeten Fälle sowie der Einsendungen an das NRZ und der positiven Nachweise merklich. International wird inzwischen ein Wiederaufflammen der Masernaktivität beobachtet

Planet Hunters: The First Two Planet Candidates Identified by the Public using the Kepler Public Archive Data

Planet Hunters is a new citizen science project, designed to engage the public in an exoplanet search using NASA Kepler public release data. In the first month after launch, users identified two new planet candidates which survived our checks for false- positives. The follow-up effort included analysis of Keck HIRES spectra of the host stars, analysis of pixel centroid offsets in the Kepler data and adaptive optics imaging at Keck using NIRC2. Spectral synthesis modeling coupled with stellar evolutionary models yields a stellar density distribution, which is used to model the transit orbit. The orbital periods of the planet candidates are 9.8844 \pm0.0087 days (KIC 10905746) and 49.7696 \pm0.00039 (KIC 6185331) days and the modeled planet radii are 2.65 and 8.05 R\oplus. The involvement of citizen scientists as part of Planet Hunters is therefore shown to be a valuable and reliable tool in exoplanet detection.Comment: Submitted to MNRAS, added 1 line to table

Linking human impacts to community processes in terrestrial and freshwater ecosystems

Human impacts such as habitat loss, climate change and biological invasions are radically altering biodiversity, with greater effects projected into the future. Evidence suggests human impacts may differ substantially between terrestrial and freshwater ecosystems, but the reasons for these differences are poorly understood. We propose an integrative approach to explain these differences by linking impacts to four fundamental processes that structure communities: dispersal, speciation, species-level selection and ecological drift. Our goal is to provide process-based insights into why human impacts, and responses to impacts, may differ across ecosystem types using a mechanistic, eco-evolutionary comparative framework. To enable these insights, we review and synthesise (i) how the four processes influence diversity and dynamics in terrestrial versus freshwater communities, specifically whether the relative importance of each process differs among ecosystems, and (ii) the pathways by which human impacts can produce divergent responses across ecosystems, due to differences in the strength of processes among ecosystems we identify. Finally, we highlight research gaps and next steps, and discuss how this approach can provide new insights for conservation. By focusing on the processes that shape diversity in communities, we aim to mechanistically link human impacts to ongoing and future changes in ecosystems

Linking human impacts to community processes in terrestrial and freshwater ecosystems.

Human impacts such as habitat loss, climate change and biological invasions are radically altering biodiversity, with greater effects projected into the future. Evidence suggests human impacts may differ substantially between terrestrial and freshwater ecosystems, but the reasons for these differences are poorly understood. We propose an integrative approach to explain these differences by linking impacts to four fundamental processes that structure communities: dispersal, speciation, species-level selection and ecological drift. Our goal is to provide process-based insights into why human impacts, and responses to impacts, may differ across ecosystem types using a mechanistic, eco-evolutionary comparative framework. To enable these insights, we review and synthesise (i) how the four processes influence diversity and dynamics in terrestrial versus freshwater communities, specifically whether the relative importance of each process differs among ecosystems, and (ii) the pathways by which human impacts can produce divergent responses across ecosystems, due to differences in the strength of processes among ecosystems we identify. Finally, we highlight research gaps and next steps, and discuss how this approach can provide new insights for conservation. By focusing on the processes that shape diversity in communities, we aim to mechanistically link human impacts to ongoing and future changes in ecosystems

Autoimmunity in CD73/Ecto-5′-Nucleotidase Deficient Mice Induces Renal Injury

Extracellular adenosine formed by 5′-ectonucleotidase (CD73) is involved in tubulo-glomerular feedback in the kidney but is also known to be an important immune modulator. Since CD73−/−mutant mice exhibit a vascular proinflammatory phenotype, we asked whether long term lack of CD73 causes inflammation related kidney pathologies. CD73−/−mice (13 weeks old) showed significantly increased low molecule proteinuria compared to C57BL6 wild type controls (4.8≥0.52 vs. 2.9±0.54 mg/24 h, p<0.03). Total proteinuria increased to 5.97±0.78 vs. 2.55±0.35 mg/24 h at 30 weeks (p<0.01) whereas creatinine clearance decreased (0.161±0.02 vs. 0.224±0.02 ml/min). We observed autoimmune inflammation in CD73−/−mice with glomerulitis and peritubular capillaritis, showing glomerular deposition of IgG and C3 and enhanced presence of CD11b, CD8, CD25 as well as GR-1-positive cells in the interstitium. Vascular inflammation was associated with enhanced serum levels of the cytokines IL-18 and TNF-α as well as VEGF and the chemokine MIP-2 (CXCL-2) in CD73−/−mice, whereas chemokines and cytokines in the kidney tissue were unaltered or reduced. In CD73−/−mice glomeruli, we found a reduced number of podocytes and endothelial fenestrations, increased capillaries per glomeruli, endotheliosis and enhanced tubular fibrosis. Our results show that adult CD73−/−mice exhibit spontaneous proteinuria and renal functional deterioration even without exogenous stress factors. We have identified an autoimmune inflammatory phenotype comprising the glomerular endothelium, leading to glomeruli inflammation and injury and to a cellular infiltrate of the renal interstitium. Thus, long term lack of CD73 reduced renal function and is associated with autoimmune inflammation