Developing a new business model for enabling research - the case of the ACPFG in Australia

Publisher's postprint archived as permitted by publisher.The way in which companies, research centres and educational institutions are organised and structured may provide a competitive advantage for commercialisation, in particular if companies are dependent on the deployment of complementary assets and capabilities by third parties. This paper presents the case of the Australian Centre for Plant Functional Genomics (ACPFG), a private agricultural biotechnology (agbiotech) company specialising in early stage Research and Development (R&D) to produce superior adapted cereal varieties, tolerant to abiotic stress conditions such as drought, frost, salt, or mineral toxicity, all of which have a direct and negative impact on plant growth and crop productivity. The organisational structure of the company has been influenced and shaped by Government policy, shareholders expectations and trends in the agbiotech industrial organisation. It has proved attractive to potential alliance partners for collaborative R&D and commercialisation. We present the ACPFG as a new business model to fund basic research and facilitate technology transfer.Stephanie C. Agius, David Corkindale, Antonio G. Dottore, Michael Gilber

Constitutive Modeling of Additive Manufactured Ti-6Al-4V Cyclic Elastoplastic Behaviour

Metal additive manufacturing techniques have been increasingly attracting the interest of the aerospace and biomedical industry. A particular focus has been on high value and complexity parts and components, as there the advantages offered by additive manufacturing are very significant for the design and production organisations. Various additive manufacturing techniques have been tested and utilized over the past years, with laser-based technology being among the preferred solutions – e.g. selective laser melting / sintering (SLM / SLS). Fatigue qualification, as one of the primary design challenges to meet, imposes the need for extensive material testing. Moreover, this need is amplified by the fact that currently there is very limited in-service experience and understanding of the distinct mechanical behaviour of additively manufactured metallic materials. To this end, material modelling can serve as a mediator, nevertheless research particular to additively manufactured metals is also quite limited. This work attempts to identify the cyclic elastoplastic behaviour characteristics of SLM manufactured Ti-6Al-4V. A set of uniaxial stress and strain controlled mechanical tests have been conducted on as-built SLM coupons. Phenomena critical for engineering applications and interrelated to fatigue performance (mean stress relaxation, ratcheting) have been examined under the prism of constitutive modeling. Cyclic plasticity models have been successfully employed to simulate the test results. Moreover, a preliminary analysis has been conducted on the differences observed in the elastoplastic behaviour of SLM and conventionally manufactured Ti-6Al-4V and their possible connection to material performance in the high cycle fatigue regime

NEUROPSYCHIATRIC MANIFESTATIONS OF COLLOID CYSTS: A REVIEW OF THE LITERATURE

Colloid cysts account for approximately 2% of primary brain tumours and the majority of cases are identified in the fourth and fifth decade. They are small, gelatinous neoplasms lined by a single layer of mucin-secreting columnar epithelium that are thought to arise from errors in folding of the primitive neuroepithelium. They develop in the rostral aspect of the third ventricle in the foramen of Monro in 99% of cases and despite their benign histology carry a poor prognosis, with a mortality greater than 10% in symptomatic cases. The location of colloid cysts within the ventricular system results in obstruction of the foramen of Monro as the cyst grows, disrupting the circulation of cerebrospinal fluid (CSF) and causing hydrocephalus. This is the mechanism behind the most common presenting symptoms of postural headache, nausea and vomiting - a clinical picture synonymous with hydrocephalus and intracranial pathology. In addition to these classical neurological symptoms, there is a high prevalence of psychiatric symptoms in the patient population, with symptoms ranging from anterograde amnesia to gustatory hallucination. These symptoms can occur with or without the presence of hydrocephalus, and are thought to be secondary to compression of connecting pathways between the mesocortices and subcortical limbic regions. These symptoms have been shown to be comparative in frequency to the classical symptoms, yet are rarely the reason for referral to a neurological or neurosurgical service for investigation

Reducing Extrinsic Burdens on Players of Digital Games: An Integrated Framework

Increasingly complex gameplay and gameworlds are placing greater demands on players, while grander approaches to help them cope, such as heads-up displays (HUDs), maps, notifications, and real-time statistics, may often create even more layers of complexity, and thus burdens, further detaching players from core gameplay. In this article, we distinguish between ‘intrinsic’ (fundamental to gameplay) and ‘extrinsic’ (peripheral or extraneous to gameplay) game elements, where the latter may be seen to increase burdens on players unnecessarily, subsequently affecting engagement. We propose a framework, comprising core, interaction, and interface layers, that reveals how extrinsicality may be minimised to better facilitate intrinsic gameplay and engagement

Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines

Glycogen phosphorylase (GP) is a validated target for the development of new type 2 diabetes treatments. Exploiting the Zinc docking database, we report the in silico screening of 1888 β- D-glucopyranose-NH-CO-R putative GP inhibitors differing only in their R groups. CombiGlide and GOLD docking programs with different scoring functions were employed with the best performing methods combined in a “consensus scoring” approach to ranking of ligand binding affinities for the active site. Six selected candidates from the screening were then synthesized and their inhibitory potency was assessed both in vitro and ex vivo. Their inhibition constants’ values, in vitro, ranged from 5 to 377 µM while two of them were effective at causing inactivation of GP in rat hepatocytes at low µM concentrations. The crystal structures of GP in complex with the inhibitors were defined and provided the structural basis for their inhibitory potency and data for further structure based design of more potent inhibitors

Reflective agents for personalisation in collaborative games

The collaborative aspect of games has been shown to potentially increase player performance and engagement over time. However, collaborating players need to perform well for the team as a whole to benefit and thus teams often end up performing no better than a strong player would have performed individually. Personalisation offers a means for improving overall performance and engagement, but in collaborative games, personalisation is seldom implemented, and when it is, it is overwhelmingly passive such that the player is not guided to goal states and the effectiveness of the personalisation is not evaluated and adapted accordingly. In this paper, we propose and apply the use of reflective agents to personalisation (‘reflective personalisation’) in collaborative gaming for individual players within collaborative teams via a combination of individual player and team profiling in order to improve player and thus team performance and engagement. The reflective agents self-evaluate, dynamically adapting their personalisation techniques to most effectively guide players towards specific goal states, match players and form teams. We incorporate this agent-based approach within a microservices architecture, which itself is a set of collaborating services, to facilitate a scalable and portable approach that enables both player and team profiles to persist across multiple games. An experiment involving 90 players over a two-month period was used to comparatively assess three versions of a collaborative game that implemented reflective, guided, and passive personalisation for individual players within teams. Our results suggest that the proposed reflective personalisation approach improves team player performance and engagement within collaborative games over guided or passive personalisation approaches, but that it is especially effective for improving engagement

On the information-theoretic formulation of network participation

The participation coefficient is a widely used metric of the diversity of a node's connections with respect to a modular partition of a network. An information-theoretic formulation of this concept of connection diversity, referred to here as participation entropy, has been introduced as the Shannon entropy of the distribution of module labels across a node's connected neighbors. While diversity metrics have been studied theoretically in other literatures, including to index species diversity in ecology, many of these results have not previously been applied to networks. Here we show that the participation coefficient is a first-order approximation to participation entropy and use the desirable additive properties of entropy to develop new metrics of connection diversity with respect to multiple labelings of nodes in a network, as joint and conditional participation entropies. The information-theoretic formalism developed here allows new and more subtle types of nodal connection patterns in complex networks to be studied

Acceptability and feasibility of point-of-care CD4 testing on HIV continuum of care in low and middle income countries: a systematic review

Background: CD4 testing is, and will remain an important part of HIV treatment and care in low and middle income countries (LMICs). We report the findings of a systematic review assessing acceptability and feasibility of POC CD4 testing in field settings. Methods: Electronic databases were searched for studies published in English between 2005 and 2015 that describe POC CD4 platforms. Studies conducted in LMICs and under field conditions outside a laboratory environment were eligible. Qualitative and descriptive data analysis was used to present the findings. Results: Twelve studies were included, 11 of which were conducted in sub-Saharan countries and used one POC CD4 test (The Alere Pima CD4). Patients reported positively regarding the implementation of POC CD4 testing at primary health care and community level with ≥90 % of patients accepting the test across various study settings. Health service providers expressed preference toward POC CD4 testing as it is easy-to-use, efficient and satisfied patients\u27 needs to a greater extent as compared to conventional methods. However, operational challenges including preference toward venous blood rather than finger-prick sampling, frequent device failures and operator errors, quality of training for test operators and supervisors, and increased staff workload were also identified. Conclusions: POC CD4 testing seems acceptable and feasible in LIMCs under field conditions. Further studies using different POC CD4 tests available on the market are required to provide critical data to support countries in selection and implementation of appropriate POC CD4 technologies