40 research outputs found
ENHANCING E-COMMERCE CUSTOM REGULATION FOR SEAMLESS TRADE IN EAEU: A POLICY PAPER
This policy paper provides a comprehensive analysis of the e-commerce sector within the Eurasian Economic Union (EAEU), highlighting its challenges, opportunities, and potential for driving economic growth. It sets forth a series of well-crafted policy recommendations aimed at establishing a conducive environment for e-commerce development. By implementing these measures, policymakers can fully unleash the potential of e-commerce, fostering economic growth, and advancing digital inclusion. As the e-commerce sector flourishes, it necessitates the establishment of a fair and efficient regulatory framework to facilitate smooth cross-border transactions. Addressing the custom regulation and taxation of e-commerce transactions requires collaborative efforts. Policymakers must strive to develop transparent and equitable customs and taxation systems that prevent tax evasion while easing the burden on small and medium-sized enterprises. One essential consideration is the implementation of destination-based taxation, ensuring that taxes are paid in the countries where products and services are consumed. This approach fosters fairness and discourages tax avoidance strategies. The policy paper aims to propose specific measures to enhance e-commerce custom regulation, effectively tackling the unique challenges presented by online trade. Leveraging technology and fostering international cooperation are pivotal in designing streamlined customs processes, creating an enabling environment for e-commerce growth. Such endeavors will ensure compliance, minimize illicit activities, and foster a flourishing e-commerce landscape within the EAEU
ΠΡΠ±ΠΎΡ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π²Π½ΡΡΡΠΈΠ³Π»Π°Π·Π½ΠΎΠ³ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π³ΠΈΠΏΠΎΡΠ΅Π½Π·ΠΈΠ²Π½ΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°Π½ΡΠΈΠ³Π»Π°ΡΠΊΠΎΠΌΠ½ΡΡ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ
Purpose of this study β to compare the results of different tonometry methods before surgical treatment of glaucoma and in the early postoperative period.The study was conducted on a group of 50 patients (50 eyes) aged 55 to 80 years with uncompensated primary open-angle glaucoma, who were admitted to in-patient department for glaucoma surgery. Patients were examined using bidirectional applanation tonometry of the cornea performed on Ocular Response Analyzer, pneumotonometry on Canon TX-20P device, and with Icare tonometer. These studies were carried out on the day before the surgery, the next day, and 2 weeks after the operation.Significant differences in tonometry readings were revealed between all tested devices at high intraocular pressure (IOP) levels (before glaucoma surgery). Significant differences were also found in IOP values obtained with Icare tonometer in the central zone of the cornea and in the middle periphery in the nasal and temporal sectors. A significant difference between the indicators remained on the next day after surgery, except for the Icare readings. After two weeks, the tonometric parameters did not differ significantly from each other.Corneal compensated IOP (IOPcc) is the most important tonometric indicator in clinical practice because it takes into account the individual biomechanical characteristics of the patientβs cornea. When examining patients with glaucoma, the IOPcc indicator significantly differed in uncompensated IOP, which is important for determining the correct treatment tactics. When assessing the level of IOP after surgery this trend persisted, indicating a systematic underestimation of IOP level (overestimation of the effect of glaucoma surgery). The reliability of the study is confirmed by the results of measurements on unoperated fellow eyes (control).Π¦Π΅Π»Ρ β ΡΡΠ°Π²Π½ΠΈΡΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠ°Π·Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠΎΠ½ΠΎΠΌΠ΅ΡΡΠΈΠΈ Π΄ΠΎ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ Π³Π»Π°ΡΠΊΠΎΠΌΡ ΠΈ Π² ΡΠ°Π½Π½Π΅ΠΌ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π² Π³ΡΡΠΏΠΏΠ΅ ΠΈΠ· 50 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² (50 Π³Π»Π°Π·) Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 55 Π΄ΠΎ 80 Π»Π΅Ρ Ρ Π½Π΅ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ ΠΎΡΠΊΡΡΡΠΎΡΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ Π³Π»Π°ΡΠΊΠΎΠΌΠΎΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΡΡΡΠΏΠ°Π»ΠΈ Π² ΡΡΠ°ΡΠΈΠΎΠ½Π°Ρ Π΄Π»Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π°Π½ΡΠΈΠ³Π»Π°ΡΠΊΠΎΠΌΠ½ΠΎΠΉ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ. ΠΡΠΏΠΎΠ»Π½ΡΠ»ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π΄Π²ΡΠ½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΉ ΠΏΠ½Π΅Π²ΠΌΠΎΠ°ΠΏΠ»Π°Π½Π°ΡΠΈΠΈ ΡΠΎΠ³ΠΎΠ²ΠΈΡΡ Π½Π° Π±ΠΈΠΎΠΌΠ΅Ρ
Π°Π½ΠΈΡΠ΅ΡΠΊΠΎΠΌ Π°Π½Π°Π»ΠΈΠ·Π°ΡΠΎΡΠ΅ Ocular Response Analyzer, Π±Π΅ΡΠΊΠΎΠ½ΡΠ°ΠΊΡΠ½ΡΡ ΡΠΎΠ½ΠΎΠΌΠ΅ΡΡΠΈΡ ΠΏΡΠΈΠ±ΠΎΡΠΎΠΌ Canon TX-20P ΠΈ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ½ΠΎ- ΠΌΠ΅ΡΡΠΎΠΌ Icare. ΠΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π·Π° Π΄Π΅Π½Ρ Π΄ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π°Π½ΡΠΈΠ³Π»Π°ΡΠΊΠΎΠΌΠ½ΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π°, Π½Π° ΡΠ»Π΅Π΄ΡΡΡΠΈΠΉ Π΄Π΅Π½Ρ ΠΈ ΡΠ°ΠΊΠΆΠ΅ ΡΠ΅ΡΠ΅Π· 2 Π½Π΅Π΄Π΅Π»ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ. ΠΡΠΈ Π²ΡΡΠΎΠΊΠΈΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΡΡ
Π²Π½ΡΡΡΠΈΠ³Π»Π°Π·Π½ΠΎΠ³ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ (ΠΠΠ) (Π΄ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π°Π½ΡΠΈΠ³Π»Π°ΡΠΊΠΎΠΌΠ½ΠΎΠΉ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ) Π±ΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΡ ΡΠΎΠ½ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΌΠ΅ΠΆΠ΄Ρ Π²ΡΠ΅ΠΌΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠΌΠΈ ΠΏΡΠΈΠ±ΠΎΡΠ°ΠΌΠΈ. Π’Π°ΠΊΠΆΠ΅ Π±ΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΡ Π² ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡ
ΠΠΠ ΠΏΡΠΈ ΡΠΎΠ½ΠΎΠΌΠ΅ΡΡΠΈΠΈ Icare Π² ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π·ΠΎΠ½Π΅ ΡΠΎΠ³ΠΎΠ²ΠΈΡΡ ΠΈ Π½Π° ΡΡΠ΅Π΄Π½Π΅ΠΉ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΠΈ Π² Π½ΠΎΡΠΎΠ²ΠΎΠΌ ΠΈ Π²ΠΈΡΠΎΡΠ½ΠΎΠΌ ΡΠ΅ΠΊΡΠΎΡΠ°Ρ
. ΠΠ° ΡΠ»Π΅Π΄ΡΡΡΠΈΠΉ Π΄Π΅Π½Ρ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½Π°Ρ ΡΠ°Π·Π½ΠΈΡΠ° ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΠΎΡ
ΡΠ°Π½ΡΠ»Π°ΡΡ, Π·Π° ΠΈΡΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Icare. Π§Π΅ΡΠ΅Π· 2 Π½Π΅Π΄Π΅Π»ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ ΡΠΎΠ½ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΎΠ±ΠΎΠΉ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π½Π΅ ΡΠ°Π·Π»ΠΈΡΠ°Π»ΠΈΡΡ. Π ΠΎΠ³ΠΎΠ²ΠΈΡΠ½ΠΎ-ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ ΠΠΠ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²Π°ΠΆΠ½ΡΠΌ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΏΠ»Π°Π½Π΅ ΡΠΎΠ½ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΌ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΡΡΠΈΡΡΠ²Π°Π΅Ρ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΈΠ±ΡΠΎΠ·Π½ΠΎΠΉ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ Π³Π»Π°Π·Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΡΠΈ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π³Π»Π°ΡΠΊΠΎΠΌΠΎΠΉ ΡΡΠΎΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΠΎΡΠ»ΠΈΡΠ°Π΅ΡΡΡ ΠΏΡΠΈ Π½Π΅ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΌ ΠΠΠ, ΡΡΠΎ Π²Π°ΠΆΠ½ΠΎ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΏΡΠ°Π²ΠΈΠ»ΡΠ½ΠΎΠΉ ΡΠ°ΠΊΡΠΈΠΊΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ. ΠΡΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΠΠ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ Π΄Π°Π½Π½Π°Ρ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ ΡΠΎΡ
ΡΠ°Π½ΡΠ»Π°ΡΡ, ΡΡΠΎ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΡΡ Π½Π΅Π΄ΠΎΠΎΡΠ΅Π½ΠΊΡ ΠΎΡΡΠ°Π»ΡΠΌΠΎΡΠΎΠ½ΡΡΠ° (ΠΏΠ΅ΡΠ΅ΠΎΡΠ΅Π½ΠΊΡ ΡΡΡΠ΅ΠΊΡΠ° ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ). ΠΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°Π΅ΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°- Π½ΠΈΡ Π½Π° ΠΏΠ°ΡΠ½ΡΡ
Π½Π΅ΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π³Π»Π°Π·Π°Ρ
Transgenerational Phenomenon of Genomic Instability in Children of Irradiated Parents during ChNPP
Study of families irradiated during the accident at the Chernobyl nuclear power plant revealed significantly increased levels of aberrant genomes not only in irradiated of low doses parents (fathers-liquidators, fathers and mothers from territories contaminated with radionuclides (n = 106, p < 0.01)), but also in their children born in 1987-2004 after the accident (n = 159, p < 0.05). These children with different somatic pathologies were examined in the Children's Center of Radiation Protection of the Institute of Pediatrics and Children's Surgery of the RF Ministry of Public Health (head. - prof. Baleva L. S.). This is indicative of the transgenerational phenomenon of genomic instability. To elucidate this phenomenon, experiments were undertaken to model genomic instability by using fractionated in vitro Ξ³-irradiation (137Cs) of peripheral blood lymphocytes samples of the children and their parents at doses of 10, 20 and 30 cGy. The spectrum and frequency of chromosomes aberrations were studied in the 1st and 2nd cell generations. The children of irradiated parents (n=6). Children born from unirradiated parents (n = 3) served as a control. Parents: irradiated fathers (n = 3) and unirradiated mothers (n = 3). Single doses were 10 cGy, 20 cGy, 30 cGy. Fractional doses were 10 cGy + 10 cGy and 10 cGy + 10 cGy + 10 cGy. Blood samples were irradiated at 24 h intervals. Before culturing all blood samples were stored at 370 C. Cultivation of lymphocytes was carried out for 48 h and 72 h with the use of 5-BrdU added to differentiate between mitosis 1 and mitosis 2. Average frequency of aberrant genomes were significantly increased at all doses in the children of irradiated parents, as compared to the children born from un-irradiated parents. The magnitude of the elevation of the individual frequencies of aberrant genomes is accordance on the initial levels of the genome aberrations. This is indicative of individual radiosensitivity probably depending on genotypic peculiarities, initial state (sensitivity) of the genome, pathophysiological processes in the organism of children. Amplification of cells with single-break chromosome aberrations in the mitosis 2, as compared to mitosis 1 suggests the replication mechanism of realization of potential damage in DNA and the occurrence of genomic instability in succeeding cell generations
Systems Oncology: Bridging Pancreatic and Castrate Resistant Prostate Cancer
Large investments by pharmaceutical companies in the development of new antineoplastic drugs have not been resulting in adequate advances of new therapies. Despite the introduction of new methods, technologies, translational medicine and bioinformatics, the usage of collected knowledge is unsatisfactory. In this paper, using examples of pancreatic ductal adenocarcinoma (PaC) and castrate-resistant prostate cancer (CRPC), we proposed a concept showing that, in order to improve applicability of current knowledge in oncology, the re-clustering of clinical and scientific data is crucial. Such an approach, based on systems oncology, would include bridging of data on biomarkers and pathways between different cancer types. Proposed concept would introduce a new matrix, which enables combining of already approved therapies between cancer types. Paper provides a (a) detailed analysis of similarities in mechanisms of etiology and progression between PaC and CRPC, (b) diabetes as common hallmark of both cancer types and (c) knowledge gaps and directions of future investigations. Proposed horizontal and vertical matrix in cancer profiling has potency to improve current antineoplastic therapy efficacy. Systems biology map using Systems Biology Graphical Notation Language is used for summarizing complex interactions and similarities of mechanisms in biology of PaC and CRPC. Β© 2018, ArΓ‘nyi Lajos Foundation
Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident
As children are more susceptible to ionizing radiation than adults, each nuclear accident demands special attention and care of this vulnerable population. The Chernobyl nuclear disaster occurred in a region populated with a large number of children, but despite all efforts and expertise of nuclear specialists, it was not possible to avoid casualties. As vast regions of Ukraine, Belarus and Russia were exposed to doses of ionizing radiation, which are known to be related with different diseases, shortly after the accident medical surveillance was launched, which also included analysis of genome damage. Child population affected by internal and external radiation consisted of subjects exposed prenatally, postnatally (both evacuated and non-evacuated), born by irradiated fathers who worked as liquidators, and parents exposed environmentally. In all groups of children during the last 30Β years who were exposed to doses which were significantly higher than that recommended for general population of 1Β mSv per year, increased genome damage was detected. Increased genome damage includes statistically higher frequency of dicentric and ring chromosomes, chromated and chromosome breaks, acentric fragments, translocations, and micronuclei. The presence of rogue cells confirmed internal contamination. Genome instability and radiosensitivity in children was detected both in evacuated and continuously exposed children. Today the population exposed to ionizing radiation in 1986 is in reproductive period of life and follow-up of this population and their offspring is of great importance. This review aims to give insight in results of studies, which reported genome damage in children in journals without language restrictions. Β© 2016, Springer-Verlag Berlin Heidelberg
Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident
As children are more susceptible to ionizing radiation than adults, each nuclear accident demands special attention and care of this vulnerable population. The Chernobyl nuclear disaster occurred in a region populated with a large number of children, but despite all efforts and expertise of nuclear specialists, it was not possible to avoid casualties. As vast regions of Ukraine, Belarus and Russia were exposed to doses of ionizing radiation, which are known to be related with different diseases, shortly after the accident medical surveillance was launched, which also included analysis of genome damage. Child population affected by internal and external radiation consisted of subjects exposed prenatally, postnatally (both evacuated and non-evacuated), born by irradiated fathers who worked as liquidators, and parents exposed environmentally. In all groups of children during the last 30Β years who were exposed to doses which were significantly higher than that recommended for general population of 1Β mSv per year, increased genome damage was detected. Increased genome damage includes statistically higher frequency of dicentric and ring chromosomes, chromated and chromosome breaks, acentric fragments, translocations, and micronuclei. The presence of rogue cells confirmed internal contamination. Genome instability and radiosensitivity in children was detected both in evacuated and continuously exposed children. Today the population exposed to ionizing radiation in 1986 is in reproductive period of life and follow-up of this population and their offspring is of great importance. This review aims to give insight in results of studies, which reported genome damage in children in journals without language restrictions. Β© 2016, Springer-Verlag Berlin Heidelberg
Systems Oncology: Bridging Pancreatic and Castrate Resistant Prostate Cancer
Large investments by pharmaceutical companies in the development of new antineoplastic drugs have not been resulting in adequate advances of new therapies. Despite the introduction of new methods, technologies, translational medicine and bioinformatics, the usage of collected knowledge is unsatisfactory. In this paper, using examples of pancreatic ductal adenocarcinoma (PaC) and castrate-resistant prostate cancer (CRPC), we proposed a concept showing that, in order to improve applicability of current knowledge in oncology, the re-clustering of clinical and scientific data is crucial. Such an approach, based on systems oncology, would include bridging of data on biomarkers and pathways between different cancer types. Proposed concept would introduce a new matrix, which enables combining of already approved therapies between cancer types. Paper provides a (a) detailed analysis of similarities in mechanisms of etiology and progression between PaC and CRPC, (b) diabetes as common hallmark of both cancer types and (c) knowledge gaps and directions of future investigations. Proposed horizontal and vertical matrix in cancer profiling has potency to improve current antineoplastic therapy efficacy. Systems biology map using Systems Biology Graphical Notation Language is used for summarizing complex interactions and similarities of mechanisms in biology of PaC and CRPC. Β© 2018, ArΓ‘nyi Lajos Foundation
Genome damage in children with classical Ehlers-Danlos syndrome - An in vivo and in vitro study
Ehlers-Danlos syndrome (EDS) is a heritable connective tissue disorder characterized by skin hyperextensibility, abnormal wound healing, and joint hypermobility with prevalence 1:20 000. Its incidence is probably underestimated due to unknown number of subjects having mild symptoms who may have never been diagnosed through entire life time. Classical EDS is characterized by pathogenic variants of genes encoding type V collagen. The biological effects and health risks of patients with EDS exposure to low doses of ionizing radiation is poorly understood. The aim of this study was to investigate biological effect of low doses of ionizing radiation in children with EDS. Background values of chromosome aberrations in children suffering from classical EDS were determined and compared with control subjects. The in vitro experiment was performed by Ξ³-irradiation of blood lymphocytes from EDS patients and healthy subjects at low doses (0.1, 0.2 and 0.3 Gy). Results show a significant increase level of spontaneous and radiation-induced chromosomal aberrations in children suffering from EDS in comparison with the control subjects (p < 0.05). In conclusion, children with EDS express higher background chromosome aberration frequency and increased radiosensitivity. These findings suggest specific susceptibility of EDS patients and importance of future investigation on risks of diagnostics and therapy which include radiation and genotoxic agents. Β© 201