The stock assessment of bony fish, carp (Cyprinus carpio) and roach (Rutilus rutilus) in southern coast of the Caspian Sea

In this study, the combination of length, growth rate, mortality rate and also the current of status Operation Carp and roach commercially as important species in southern waters were reviewed. Samples were taken from beach sine net catch and fish were offered at fish market. The age composition of carp and roach was 1 to 16 and 1 to 4 years respectively, most catch carp and roach was in length range of 31 to 39 cm and 18 to 20 cm respectively. Growth parameters during the program by ELFFAN I FiSAT for Carp and Roach obtained from von Bertalanffy growth function were L_∞ =70.78 and 32.39 cm, K = 1.24/year and 1.24/year; respectively. the growth parameters such as infinite length( L_∞), growth coefficient (K) and t0 age zero base on One Brtalnfy equation estimated, 78.70, 0.14, 32.39, 0.5 ,-0.5 Total mortality coefficient Using the method of catch curve (Z), natural mortality rate using the empirical formula Pauli( M), fishing mortality (F) using the formula = Z - M and Growth performance index (Ǿ) for Carp and Roach were obtained 1.5year^-1, 0.9year^-1, 0.5year^-1, 0.26year^-1, 1.24, 0.4, 2.85 and 2.54 respectively. The biomass (B) and Maximum Sustainable Yield (MSY) with the present effort for Carp and Roach were estimated 1628.7t, 368.9t and88.06t, and 32.7t respectively

Investigation of chromosomal abnormalities and microdeletion/ microduplication(s) in fifty Iranian patients with multiple congenital anomalies

Objective: Major birth defects are inborn structural or functional anomalies with long-term disability and adverse impacts on individuals, families, health-care systems, and societies. Approximately 20 of birth defects are due to chromosomal and genetic conditions. Inspired by the fact that neonatal deaths are caused by birth defects in about 20 and 10 of cases in Iran and worldwide respectively, we conducted the present study to unravel the role of chromosome abnormalities, including microdeletion/microduplication(s), in multiple congenital abnormalities in a number of Iranian patients. Materials and Methods: In this descriptive cross-sectional study, 50 sporadic patients with Multiple Congenital Anomalies (MCA) were selected. The techniques employed included conventional karyotyping, fluorescence in situ hybridization (FISH), multiplex ligation-dependent probe amplification (MLPA), and array comparative genomic hybridisation (array-CGH), according to the clinical diagnosis for each patient. Results: Chromosomal abnormalities and microdeletion/microduplication(s) were observed in eight out of fifty patients (16). The abnormalities proved to result from the imbalances in chromosomes 1, 3, 12, and 18 in four of the patients. However, the other four patients were diagnosed to suffer from the known microdeletions of 22q11.21, 16p13.3, 5q35.3, and 7q11.23. Conclusion: In the present study, we report a patient with 46,XY, der(18)12/46,XY, der(18), +mar8 dn presented with MCA associated with hypogammaglobulinemia. Given the patient�s seemingly rare and highly complex chromosomal abnormality and the lack of any concise mechanism presented in the literature to justify the case, we hereby propose a novel mechanism for the formation of both derivative and ring chromosome 18. In addition, we introduce a new 12q abnormality and a novel association of an Xp22.33 duplication with 1q43q44 deletion syndrome. The phenotype analysis of the patients with chromosome abnormality would be beneficial for further phenotype-genotype correlation studies. © 2019 Royan Institute (ACECR). All rights reserved

A novel mutation in the ALS2 gene in an iranian kurdish family with juvenile amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a rare disorder that affects both upper and lower motor neurons. Mutations in Alsin Rho Guanine Nucleotide Exchange Factor (ALS2) correlates with three similar but distinctive syndromes, including the juvenile form of ALS. An Iranian Kurdish family was involved in this study and all members were evaluated with relevant clinical guidelines. Whole exome sequencing and sanger sequencing were applied to all family members to undermine the possible genetic factors. A substitution c. 2110 C>T (p. Arg704X) identified in the ALS2 gene. Bioinformatics analysis indicated the mutation is located in the well-conserved and functional domain of the protein. This study recognized a novel mutation in the ALS2 gene in a proband with the juvenile form of ALS. To our knowledge, this is the first identified ALS2 mutation among the Iranian population. © 2022 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases