Supplementary Material for: Visualization of Sex-Dimorphic Changes in the Intestinal Transcriptome of <b><i>Fabp2</i></b> Gene-Ablated Mice

<b><i>Background/Aims:</i></b> Sex differences in gene expression program have not been effectively explored at the transcriptome level. We aimed to develop a method for the analysis of transcriptome data to identify sex differences and sex-dimorphic responses to experimental conditions in mice. <b><i>Methods:</i></b> Profiling of the small intestine transcriptome of chow-fed C57BL/6J (wild-type, WT) and <i>Fabp2</i>^–/– mice was carried out by microarray analysis. Sex-specific and androgynous effects of <i>Fabp2</i> gene ablation were examined using FlexArray V1.6 by comparing WT to <i>Fabp2</i>^–/– mice. The data generated were exported into a single spreadsheet, collated and transformed to identify the differentially expressed genes for pathway analysis. <b><i>Results:</i></b> The method revealed enrichment of 17 sex-dimorphic pathways in the small intestine of WT mice compared to only 4 in <i>Fabp2</i>^–/– mice. Comparison of the effects of Fabp2 loss in individual sexes revealed a male-specific upregulation of 5 pathways involved in the production of unsaturated fatty acids, and a female-specific downregulation of pathways involved in xenobiotic metabolism. <b><i>Conclusions:</i></b> Our approach detected the common as well as sex-differential pathways that are modified due to the loss of Fabp2. These findings suggest that the pathways involved in nutrient and xenobiotic metabolism in the intestine are regulated by sex-specific mechanisms

Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population*

Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper. Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The literature search yielded 448 studies, in which 10 case-control studies including 1 694 cases and 1 456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89–1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09–1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions: In the present study, the TaqIB polymorphism of CETP was found to be associated with CAD in the Chinese population