Fitting Algorithms for Optical and Beam Parameters in Transfer Lines with Application to the LHC Injection Line T12

As part of the commissioning with beam of the transfer line TI2 and TI8 from the SPS to the LHC [1], a series of optics measurements has been conducted. The paper presents the results in terms of Twiss parameters (including the dispersion), emittance and momentum spread obtained from the combination of trajectory and beam profile measurements. Profiting from the redundancy of monitors, there is a possibility of applying different fitting algorithms to retrieve beam parameters and to extract information on the optics of the line. The results from the different fit methods applied to the data will be compared with the expected values and cross-checked with independent measurements

Machine studies during beam commissioning of the SPS-to-LHC transfer lines

Through May to September 2008, further beam commissioning of the SPS-to-LHC transfer lines was performed. For the first time, optics and dispersion measurements were also taken in the last part of the lines, and into the LHC. Extensive trajectory and optics studies were conducted, in parallel with hardware checks. In particular dispersion measurements and their comparison with the beam line model were analysed in detail and led to propose the addition of a dispersion-free steering algorithm in the existing trajectory correction program. Its effectiveness was simulated and is briefly discussed

Expansion of knowledge about intellectualization of the user task launch process in the distributed computational system

The relevance of expanding knowledge about the intellectualization of the task launch process in distributed computing systems is grounded, describes the content of a generalized system of knowledge representation about the intelligent service management of the global task queue, presents techniques for the organization and functioning of the intellectual serviceОбоснована актуальность расширения знаний об интеллектуализации процесса запуска заданий в распределённых вычислительных системах, описано содержание обобщённой системы представления знаний об интеллектуальном сервисе управления глобальной очередью заданий, представлены приёмы организации и функционирования интеллектуального сервис

Initial results from beam commissioning of the LHC beam dump system

Initial commissioning of the LHC beam dump system with beam took place in August and September 2008. The preparation, setting-up and the tests performed are described together with results of the extractions of beam into the dump lines. Analysis of the first detailed aperture measurements of the extraction channels and kicker performance derived from dilution sweep shapes are presented. The performance of the other equipment subsystems is summarised, in particular that of the dedicated dump system beam instrumentation

ABOUT DIAGNOSTICS OF THE PATIENT WITH SUSPICION TO SEVERE ACUTE RESPIRATORY SYNDROME (SARS) IN CHITA CITY

A complex of diagnostic measures for detection of a suspected SARS patient is analyzed. Clinical course of the disease in dynamics especially at the early stages allowed to suspect SARS in a worker arrived from China. The diagnosis was cancelled on the basis of the clinical data and laboratory negative results. However, this case allowed to practically perfect tactics of interactions between different services during realization of anti-epidemic measures in a case of SARS suspicion including notification, hospital basis development and PCR-diagnostics adoption

Mediastinal Emphysema as a Specific Complication of COVID-19 (Case Report)

During the care of patients with novel coronavirus infection at the Lomonosov MSU Medical Research and Education Center from April 21 to June 13, 2020, we observed cases of spontaneous mediastinal emphysema (spontaneous pneumomediastinum) as a manifestation or a probable complication of COVID-19.The aim of the paper. To provide clinical case descriptions and approaches to the management of patients with spontaneous pneumomediastinum in COVID-19 associated pneumonia, as they are not addressed in the current clinical guidelines, and therefore are worthy of special attention.Among 224 patients with laboratory-confirmed diagnosis of the novel coronavirus infection COVID-19, five cases of pneumomediastinum without pneumothorax were identified. Of these, in two cases the pneumomediastinum developed during noninvasive lung ventilation (NLV) (one case) and invasive lung ventilation (one case). In three cases, spontaneous mediastinal emphysema was not associated with lung ventilation. By the time of publication, one case of pneumomediastinum was completed, and four patients remained hospitalized. All five patients were males aged from 52 to 84 years.This paper presents in depth the description of two cases of mediastinal and subcutaneous emphysema in patients with COVID-19

Basal epithelial stem cells cross an alarmin checkpoint for postviral lung disease

Epithelial cells are charged with protection at barrier sites, but whether this normally beneficial response might sometimes become dysfunctional still needs definition. Here, we recognized a pattern of imbalance marked by basal epithelial cell growth and differentiation that replaced normal airspaces in a mouse model of progressive postviral lung disease due to the Sendai virus. Single-cell and lineage-tracing technologies identified a distinct subset of basal epithelial stem cells (basal ESCs) that extended into gas-exchange tissue to form long-term bronchiolar-alveolar remodeling regions. Moreover, this cell subset was selectively expanded by crossing a cell-growth and survival checkpoint linked to the nuclear-localized alarmin IL-33 that was independent of IL-33 receptor signaling and instead connected to autocrine chromatin accessibility. This mechanism creates an activated stem-progenitor cell lineage with potential for physiological or pathological function. Thus, conditional loss of Il33 gene function in basal epithelial cells disrupted the homeostasis of the epithelial barrier at skin and gut sites but also markedly attenuated postviral disease in the lung based on the downregulation of remodeling and inflammation. Thus, we define a basal ESC strategy to deploy innate immune machinery that appears to overshoot the primordial goal of self-defense. Our findings reveal new targets to stratify and correct chronic and often deadly postviral disease