General versus Spinal Anesthesia: Comparison of Complications and Outcomes in Lumbar Laminectomy Surgery

Background: This study was designed to compare the complications and outcomes of lumbar laminectomy surgery performed by general and spinal anesthesia. Methods: In this prospective study, 110 patients with two common degenerative spinal diseases (lumbar discopathy and spinal canal stenosis) were enrolled. All the patients were operated in Bahonar hospital, Kerman City, Iran, via either spinal or general anesthesia by a unique surgeon. Intraoperative and postoperative complications and outcomes were compared between the two groups using descriptive and analytic statistics methods. Results: Surgeon satisfaction of anesthesia, blood loss, and admission time were not statistically significant between the groups. But, postoperative pain at recovery room, and 1, 2, and 12 hours after the operation was significantly higher in general anesthesia compared to lumbar anesthesia. Morphine request was also significantly higher with general anesthesia (P < 0.001). Conclusion: This study demonstrates that general anesthesia has greater pain in comparison with spinal anesthesia that should be considered in degenerative spinal diseases surgeries. Keywords Laminectomy; Lumbar region; surgery; General anesthesia; Spinal anesthesi

Docking-Based Screening of Cell-Penetrating Peptides with Antiviral Features and Ebola Virus Proteins as a Drug Discovery Approach to Develop a Treatment for Ebola Virus Disease

Ebola drug discovery continues to be challenging as yet. Proteins of the virus should be targeted at the relevant biologically active site for drug or inhibitor binding to be effective. In this regard, by considering the important role of Ebola virus proteins in the viral mechanisms of this viral disease, the Ebola proteins are selected as our drug targets in this study. The discovery of novel therapeutic molecules or peptides will be highly expensive; therefore, we attempted to identify possible antigens of EBOV proteins by conducting docking-based screening of cell penetrating peptides (CPPs) that have antiviral potential features utilizing Hex software version 8.0.0. The E-value scores obtained in this research were very much higher than the previously reported docking studies. CPPs that possess suitable interaction with the targets would be specified as promising candidates for further in vitro and in vivo examination aimed at developing new drugs for Ebola infection treatment

targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer contradictory effects and future perspectives

Abstract Breast cancer is the most common type of cancer among women. Therefore, discovery of new and effective drugs with fewer side effects is necessary to treat it. Sulforaphane (SFN) is an organosulfur compound obtained from cruciferous plants, such as broccoli and mustard, and it has the potential to treat breast cancer. Hence, it is vital to find out how SFN targets certain genes and cellular pathways in treating breast cancer. In this review, molecular targets and cellular pathways of SFN are described. Studies have shown SFN inhibits cell proliferation, causes apoptosis, stops cell cycle and has anti-oxidant activities. Increasing reactive oxygen species (ROS) produces oxidative stress, activates inflammatory transcription factors, and these result in inflammation leading to cancer. Increasing anti-oxidant potential of cells and discovering new targets to reduce ROS creation reduces oxidative stress and it eventually reduces cancer risks. In short, SFN effectively affects histone deacetylases involved in chromatin remodeling, gene expression, and Nrf2 anti-oxidant signaling. This review points to the potential of SFN to treat breast cancer as well as the importance of other new cruciferous compounds, derived from and isolated from mustard, to target Keap1 and Akt, two key regulators of cellular homeostasis