26 research outputs found
Mammals in Portugal: A data set of terrestrial, volant, and marine mammal occurrences in Portugal
Open Research: The complete data set is available as Supporting Information and are also
available in Figshare at https://doi.org/10.6084/m9.figshare.14938437Mammals are threatened worldwide, with ca. 26% of all species being
included in the IUCN threatened categories. This overall pattern is primarily associated to
habitat loss or degradation, and human persecution for terrestrial mammals, and pollution,
open net fishing, climate change and prey depletion for marine mammals. Mammals play
a key role in maintaining ecosystems functionality and resilience, and therefore
information on their distribution is crucial to delineate and support conservation actions.
MAMMALS IN PORTUGAL is a publicly available data set compiling unpublished georeferenced
occurrence records of 92 terrestrial, volant, and marine mammals in mainland
Portugal and archipelagos of Azores and Madeira that includes 107,852 data entries
between 1873 and 2021 (72% of the data occurring in 2000 and 2021). The methods used
to collect the data were: live observations/captures (42%), sign surveys (38%), camera
trapping (16%), bioacoustics surveys (4%) and radio-tracking and inquiries that represent
less than 1% of the records. The data set includes 13 types of records: 1) burrows | soil
mounds | tunnel, 2) capture, 3) colony, 4) dead animal | hair | skulls | jaws, 5) genetic
confirmation, 6) inquiries, 7) observation of live animal, 8), observation in shelters, 9)
photo trapping | video, 10), predators diet | pellets | pine cones/nuts, 11) scat | track | ditch,
12) telemetry and 13) vocalization | echolocation. The spatial uncertainty of most records ranges between 0 and 100 m (76%). Rodentia (n = 34,754) has the highest number of
records followed by Chiroptera (n = 18,858), Carnivora (n = 18,594), Lagomorpha (n =
17,679), Cetartiodactyla (n = 11,568) and Eulipotyphla (n = 6,400). The data set includes
records of species classified by the IUCN as threatened (e.g., Oryctolagus cuniculus (n =
12,407), Monachus monachus (n = 1512), and Lynx pardinus (n = 197)]. We believe that
this data set may stimulate the publication of other European countries data sets which
would certainly contribute to ecology and conservation-related research, and therefore
assisting on the development of more accurate and tailored conservation management
strategies for each species. There are no copyright restrictions; please cite this data paper
when the data are used in publicationsinfo:eu-repo/semantics/acceptedVersio
First-order formalism for dark energy and dust
This work deals with first-order formalism for dark energy and dust in
standard cosmology, for models described by real scalar field in the presence
of dust in spatially flat space. The field dynamics may be standard or
tachyonic, and we show how the equations of motion can be solved by first-order
differential equations. We investigate a model to illustrate how the dustlike
matter may affect the cosmic evolution using this framework.Comment: 5 pages, 1 figure; title changed, new author included, discussions
extended, references added, version to appear in EPJ
Age at symptom onset and death and disease duration in genetic frontotemporal dementia : an international retrospective cohort study
Background: Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72. Methods: In this international, retrospective cohort study, we collected data on age at symptom onset, age at death, and disease duration for patients with pathogenic mutations in the GRN and MAPT genes and pathological expansions in the C9orf72 gene through the Frontotemporal Dementia Prevention Initiative and from published papers. We used mixed effects models to explore differences in age at onset, age at death, and disease duration between genetic groups and individual mutations. We also assessed correlations between the age at onset and at death of each individual and the age at onset and at death of their parents and the mean age at onset and at death of their family members. Lastly, we used mixed effects models to investigate the extent to which variability in age at onset and at death could be accounted for by family membership and the specific mutation carried. Findings: Data were available from 3403 individuals from 1492 families: 1433 with C9orf72 expansions (755 families), 1179 with GRN mutations (483 families, 130 different mutations), and 791 with MAPT mutations (254 families, 67 different mutations). Mean age at symptom onset and at death was 49\ub75 years (SD 10\ub70; onset) and 58\ub75 years (11\ub73; death) in the MAPT group, 58\ub72 years (9\ub78; onset) and 65\ub73 years (10\ub79; death) in the C9orf72 group, and 61\ub73 years (8\ub78; onset) and 68\ub78 years (9\ub77; death) in the GRN group. Mean disease duration was 6\ub74 years (SD 4\ub79) in the C9orf72 group, 7\ub71 years (3\ub79) in the GRN group, and 9\ub73 years (6\ub74) in the MAPT group. Individual age at onset and at death was significantly correlated with both parental age at onset and at death and with mean family age at onset and at death in all three groups, with a stronger correlation observed in the MAPT group (r=0\ub745 between individual and parental age at onset, r=0\ub763 between individual and mean family age at onset, r=0\ub758 between individual and parental age at death, and r=0\ub769 between individual and mean family age at death) than in either the C9orf72 group (r=0\ub732 individual and parental age at onset, r=0\ub736 individual and mean family age at onset, r=0\ub738 individual and parental age at death, and r=0\ub740 individual and mean family age at death) or the GRN group (r=0\ub722 individual and parental age at onset, r=0\ub718 individual and mean family age at onset, r=0\ub722 individual and parental age at death, and r=0\ub732 individual and mean family age at death). Modelling showed that the variability in age at onset and at death in the MAPT group was explained partly by the specific mutation (48%, 95% CI 35\u201362, for age at onset; 61%, 47\u201373, for age at death), and even more by family membership (66%, 56\u201375, for age at onset; 74%, 65\u201382, for age at death). In the GRN group, only 2% (0\u201310) of the variability of age at onset and 9% (3\u201321) of that of age of death was explained by the specific mutation, whereas 14% (9\u201322) of the variability of age at onset and 20% (12\u201330) of that of age at death was explained by family membership. In the C9orf72 group, family membership explained 17% (11\u201326) of the variability of age at onset and 19% (12\u201329) of that of age at death. Interpretation: Our study showed that age at symptom onset and at death of people with genetic frontotemporal dementia is influenced by genetic group and, particularly for MAPT mutations, by the specific mutation carried and by family membership. Although estimation of age at onset will be an important factor in future pre-symptomatic therapeutic trials for all three genetic groups, our study suggests that data from other members of the family will be particularly helpful only for individuals with MAPT mutations. Further work in identifying both genetic and environmental factors that modify phenotype in all groups will be important to improve such estimates. Funding: UK Medical Research Council, National Institute for Health Research, and Alzheimer's Society
Efeito da administração de propileno glicol e cobalto associado à vitamina B12 sobre o perfil metabólico e a atividade enzimática de ovelhas da raça Santa Inês no periparto
Proteinograma do soro lácteo de ovelhas da raça Santa Inês em diferentes fases de lactação
Avaliação dos perfis minerais séricos, urinários e sedimentares de ovinos recebendo dieta calculogênica
Bringing together culture, profession and self: Creative writing as research
No abstract availabl
Computer Aided Methods & Tools for Separation & Purification of Fine Chemical & Pharmaceutical Products
Structure and localization of an essential transmembrane segment of the proton translocation channel of yeast H+-V-ATPase
AbstractVacuolar (H+)-ATPase (V-ATPase) is a proton pump present in several compartments of eukaryotic cells to regulate physiological processes. From biochemical studies it is known that the interaction between arginine 735 present in the seventh transmembrane (TM7) segment from subunit a and specific glutamic acid residues in the subunit c assembly plays an essential role in proton translocation. To provide more detailed structural information about this protein domain, a peptide resembling TM7 (denoted peptide MTM7) from Saccharomyces cerevisiae (yeast) V-ATPase was synthesized and dissolved in two membrane-mimicking solvents: DMSO and SDS. For the first time the secondary structure of the putative TM7 segment from subunit a is obtained by the combined use of CD and NMR spectroscopy. SDS micelles reveal an α-helical conformation for peptide MTM7 and in DMSO three α-helical regions are identified by 2D 1H-NMR. Based on these conformational findings a new structural model is proposed for the putative TM7 in its natural environment. It is composed of 32 amino acid residues that span the membrane in an α-helical conformation. It starts at the cytoplasmic side at residue T719 and ends at the luminal side at residue W751. Both the luminal and cytoplasmatic regions of TM7 are stabilized by the neighboring hydrophobic transmembrane segments of subunit a and the subunit c assembly from V-ATPase