31 research outputs found
ISG15 Modulates Development of the Erythroid Lineage
- Author
- A Diwan
- A Halupa
- A Kolbus
- A Okumura
- A Osiak
- A Pincetic
- Ana Leticia Maragno
- Andrew C. Wilber
- B Li
- BM Zhu
- C Tian
- C Zhao
- Christine Tran Quang
- Dong-Er Zhang
- F Okumura
- Frederic Tangy
- GA Versteeg
- H Dolznig
- H Dolznig
- H Dolznig
- H Wu
- HJ Liao
- HX Shi
- Hélène Alcalde
- I Lebigot
- I Lesault
- J Fang
- J Liu
- J Zhang
- Jacques Ghysdael
- KI Kim
- KJ Quadrini
- KJ Ritchie
- Klaus-Peter Knobeloch
- LA Durfee
- M Owhashi
- M Socolovsky
- M Socolovsky
- M von Lindern
- M von Lindern
- MA Kerenyi
- Martine Pironin
- N Reich
- OA Malakhova
- PA Gregoli
- RL Schweers
- S Guihard
- S Morita
- SD Desai
- T Takeuchi
- TL Lee
- U Muller
- W Aerbajinai
- X Zhang
- Xiuli Cong
- Y Zermati
- Z Yao
- Publication venue
- Public Library of Science
- Publication date
- 12/10/2011
- Field of study
Activation of erythropoietin receptor allows erythroblasts to generate erythrocytes. In a search for genes that are up-regulated during this differentiation process, we have identified ISG15 as being induced during late erythroid differentiation. ISG15 belongs to the ubiquitin-like protein family and is covalently linked to target proteins by the enzymes of the ISGylation machinery. Using both in vivo and in vitro differentiating erythroblasts, we show that expression of ISG15 as well as the ISGylation process related enzymes Ube1L, UbcM8 and Herc6 are induced during erythroid differentiation. Loss of ISG15 in mice results in decreased number of BFU-E/CFU-E in bone marrow, concomitant with an increased number of these cells in the spleen of these animals. ISG15-/- bone marrow and spleen-derived erythroblasts show a less differentiated phenotype both in vivo and in vitro, and over-expression of ISG15 in erythroblasts is found to facilitate erythroid differentiation. Furthermore, we have shown that important players of erythroid development, such as STAT5, Globin, PLC γ and ERK2 are ISGylated in erythroid cells. This establishes a new role for ISG15, besides its well-characterized anti-viral functions, during erythroid differentiation
Glia maturation factor gamma regulates the migration and adherence of human T lymphocytes
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
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- A Gaeta
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- A Gopalakrishnan
- A Hald
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- WY Ong
- X Chen
- X Chen
- X He
- X Huang
- X Huang
- X Huang
- X Li
- X Zhang
- X Zhu
- X Zhu
- XD Huang
- XJ Li
- XM Yuan
- XM Yuan
- XP Huang
- Y Almog
- Y Avramovich-Tirosh
- Y Bao
- Y Bdolah
- Y Chen
- Y Christen
- Y Curin
- Y Deugnier
- Y Deugnier
- Y Engin-Üstün
- Y Ge
- Y Gilgun-Sherki
- Y Haruna
- Y Honda
- Y Hua
- Y Ikeda
- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
- Y Levites
- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
A novel gene expression signature for bone metastasis in breast carcinomas
- Author
- A Komatsu
- AF Chambers
- AJ Minn
- AJ Minn
- AL Harris
- AM Sieuwerts
- AP Feinberg
- C Coulouarn
- C Frantz
- C. Dilara Savci-Heijink
- CA Drukker
- CD Savci-Heijink
- CG Korkmaz
- CJ Aslakson
- CJ Groger
- CJ Maia
- D Xuan
- DF Hayes
- DM Gilkes
- DS Nuyten
- Early Breast Cancer Trialists’ Collaborative G
- F Liu
- G Hu
- G Lorusso
- GL Semenza
- GW Sledge Jr
- Hans Halfwerk
- I Bieche
- IJ Fidler
- J Bartkova
- J Long
- J O’Shaughnessy
- Jan Koster
- JC Harrell
- JM Tiang
- JM Tiang
- JM Tiang
- JS Parker
- JT Chi
- KR Levental
- KS Sugamori
- L Ding
- M Dolled-Filhart
- M Wottawa
- Marc J. van de Vijver
- MB Burns
- MB Burns
- MG Yussman
- MJ Vijver van de
- MW Conklin
- N Laurieri
- PA Greenberg
- PD Bos
- PD Bos
- PJ Adam
- PP Provenzano
- RO Hynes
- RS Hubert
- S Mook
- S Pennacchietti
- SA Roberts
- SB Fox
- SH Giordano
- T Landemaine
- T Sorlie
- W Aerbajinai
- XH Zhang
- XH Zhang
- Y Endo
- Y Kang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Comparative Proteomic Analysis of Murine Cutaneous Lesions Induced by Leishmania amazonensis or Leishmania major
- Author
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
1H, 13C and 15N resonance assignments for proapoptotic protein Nix (residue 1∼156) from Danio rerio
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Thalidomide Resistance Is Based on the Capacity of the Glutathione-Dependent Antioxidant Defense
- Author
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Nix Nought Nothing: Fairy tale or real deal
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Mitophagy in degenerative joint diseases
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Contractile Skeletal Muscle Cells Cultured with a Conducting Soft Wire for Effective, Selective Stimulation
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study