Indonesian Road Data Center (Irodco) For Supporting Sustainable Road Development

One of the problems on current road infrastructure development in Indonesia is the difficulty of getting road data information, for example is data for supporting sustainable road infrastructure development. Moreover, some of road authority did not realize that data is important element in the cycle process of road infrastructure development. Inaccurate road data will decrease the quality of road budgeting and programming, on the other hand it will affect the period service of road itself. The good road data could support sustainable road by providing the road value such as historical, current condition, and prediction. Indonesian Road Data Center Operations (IRODCO) is a concept of integrated road database storage. Collaborate data from Indonesian road authority (Ministry of Public Work and Housing, Ministry of Transportation, National Police and Local Government) can be stored, processed and managed to be a value- added information. IRODCO will provide various information, completely, easily and quickly for supporting the sustainable development of road infrastructure. This paper will explain the background of IRODCO concept, type of road database, the architecture, and how this concept will be implementing in Indonesia next, particularly for supporting the sustainable road infrastructure development

What lies beneath: exploring links between asylum policy and hate crime in the UK

This paper explores the link between increasing incidents of hate crime and the asylum policy of successive British governments with its central emphasis on deterrence. The constant problematisation of asylum seekers in the media and political discourse ensures that 'anti-immigrant' prejudice becomes mainstr earned as a common-sense response. The victims are not only the asylum seekers hoping for a better life but democratic society itself with its inherent values of pluralism and tolerance debased and destabilised

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Abstract: We have determined the flux of calcium, chloride and nitrate to the McMurdo Dry Valleys region by analysing snow pits for their chemical composition and their snow accumulation using multiple records spanning up to 48 years. The fluxes demonstrate patterns related to elevation and proximity to the ocean. In general, there is a strong relationship between the nitrate flux and snow accumulation, indicating that precipitation rates may have a great influence over the nitrogen concentrations in the soils of the valleys. Aeolian dust transport plays an important role in the deposition of some elements (e.g. Ca 2

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Number of references: 40 Non-standard abbreviations: ASIC, acid-sensing ion channel; CPMG, Carr-PurcellMeiboom-Gill; ICK, inhibitor cystine knot; IPTG, isopropyl β -D-1-thiogalactopyranoside; k ex , chemical/conformational exchange rate; NOE, nuclear Overhauser effect; π-TRTX-Pc1a, π-theraphotoxin-Pc1a; PcTx1, psalmotoxin-1; R 1 , longitudinal relaxation rate; R 2 , transverse relaxation rate; R 2 eff , effective transverse relaxation rate; R ex , chemical/conformational exchange rate constant; rpHPLC, reverse-phase HPLC; TEV, tobacco etch virus. MOL #72207 3 Abstract Acid-sensing ion channel 1a (ASIC1a) is a primary acid sensor in the peripheral and central nervous system. It has been implicated as a novel therapeutic target for a broad range of pathophysiological conditions including pain, ischemic stroke, depression, and autoimmune diseases such as multiple sclerosis. The only known selective blocker of ASIC1a is π-TRTX-Pc1a (PcTx1), a disulfide-rich 40-residue peptide isolated from spider venom. π-TRTX-Pc1a is an effective analgesic in rodent models of acute pain and it provides neuroprotection in a mouse model of ischemic stroke. Thus, understanding the molecular basis of the π-TRTX-Pc1a:ASIC1a interaction should facilitate development of therapeutically useful ASIC1a blockers. We therefore developed an efficient bacterial expression system in order to produce a panel of π-TRTX-Pc1a mutants for probing structureactivity relationships as well isotopically-labeled toxin for determination of its solution structure and dynamics. We demonstrate that the toxin pharmacophore resides in a β-hairpin loop that was revealed to be mobile over a wide range of timescales using molecular dynamics simulations in combination with NMR spin relaxation and relaxation dispersion measurements. The toxin:receptor interaction was modeled by in silico docking of the toxin structure onto a homology model of rat ASIC1a in a restraints-driven approach that was designed to take account of the dynamics of the toxin pharmacophore and the consequent remodeling of side-chain conformations upon receptor binding. The resulting model reveals new insights into the mechanism of action of π-TRTX-Pc1a and provides an experimentally validated template for the rational design of therapeutically useful π-TRTX-Pc1a mimetics. MOL #7220