A Note on 1-Edge Balance Index Set

A graph labeling is an assignment of integers to the vertices or edges or both, subject to certain conditions. Varieties of graph labeling have been investigated by many authors [2], [3] [5] and they serve as useful models for broad range of applications

Teaching of Critical Analysis of Drug Advertisements to Medical Students

Background: Medical practitioners utilize drug promotional materials from pharmaceutical companies as a major source of information especially in developing countries. These promotional materials can be highly informative as long as they are critically appraised but when they are accepted without question, they lead to irrational prescribing. Aim: To sensitize the students regarding WHO criteria for medicinal drug promotion and to determine the impact of teaching critical appraisal of medicinal drug promotion to medical students. Design: The medical students of second year were given a pre test questionnaire to identify the violations in generic labeling, pharmacological information, claims, relevance and references cited in the drug advertisements. Later they were sensitized about the WHO criteria for medicinal drug promotion and how to critically appraise a drug advertisement. This was followed by a post test questionnaire with the same drug advertisement. Result: The number of students answering the post test correctly was significantly (p<0.05) more than that of pre test. Conclusion: Education of medical students regarding critical analysis of drug advertisements should be a part of the medical curriculum

Evaluation of efficacy of two drug regimens of anti-retro viral therapy

Background: CD4 count is an important marker to assess the effectiveness of treatment, mortality and survival rates in HIV patients on treatment. It is an important guide to treatment as it reflects drug resistance, treatment failure and need to switch over to different regimen. Objective of the study was to assess the efficacy of tenofovir (TDF) and efavirenz (EFV) versus zidovudine (AZT) and nevirapine (NVP), in combination with lamivudine (3TC) in HIV-infected patients taking basal and after treatment CD4 count levels as tools.Methods: A retrospective observational study on 40 adult HIV patients, receiving AZT+3TC+NPV (ZLN) (group I) and 18 patients on TDF+3TC+EFV (TLE) (group II) was carried out. Demographic profile, medication prescribed, baseline CD4 cell counts, serially monitored CD4 count values and Hb% were recorded from patient's medical record. Student’s paired ‘t’ test was done to compare CD4 counts before and after treatment in individual groups. Unpaired ‘t’ test was used for the comparison of CD4 counts between the groups.Results: A very highly significant (p<0.0001) increment in CD4 count was observed in group I after treatment. Improvement in CD4 count was highly significant in group II as well with p<0.0004. The extent of improvement was significantly better (p<0.05) in group I as compared to group II. Patients in group I were better staged clinically.Conclusions: We conclude that ART regimen containing AZT/3TC/NVP is proved to be superior to TDF/3TC/EFV. However further studies need to be done, by taking drug adherence into account in a larger patient population

Characterization and hormonal modulation of immunoreactive thiamin carrier protein secreted by adult rat Leydig cells in vitro

Leydig cells isolated from adult rats and maintained under defined conditions in culture secrete a protein of molecular weight (Mr) 70 000 which is immunologically similar to chicken thiamin carrier protein (TCP). Synthesis of immunoreactive TCP by these cells is demonstrated by immunoprecipitation of [35S]methionine incorporated, newly synthesized proteins with monoclonal and polyclonal antibodies to chicken TCP. The amount of immunoreactive TCP secreted into the culture supernatant is quantitated by using a specific radioimmunoassay. Under the influence of LH, secretion of immunoreactive TCP is enhanced 3-fold and can be inhibited by up to 70% with aromatase inhibitor (1,4,6-androstatrien-3,17-dione). Cyclic AMP acts as a second messenger in the sequence of events involved in LH-induced elevation of immunoreactive TCP in Leydig cells. The effects of exogenous estradiol-17beta and diethylstilbestrol are comparable in terms of stimulation of secretion of immunoreactive TCP by these cells. Tamoxifen brought about a 70% decrease in the elevated levels of immunoreactive TCP. These results suggest that estrogen mediates immunoreactive TCP induction in hormonally stimulated adult rat Leydig cells

Stability of Influence Maximization

The present article serves as an erratum to our paper of the same title, which was presented and published in the KDD 2014 conference. In that article, we claimed falsely that the objective function defined in Section 1.4 is non-monotone submodular. We are deeply indebted to Debmalya Mandal, Jean Pouget-Abadie and Yaron Singer for bringing to our attention a counter-example to that claim. Subsequent to becoming aware of the counter-example, we have shown that the objective function is in fact NP-hard to approximate to within a factor of $O(n^{1-\epsilon})$ for any $\epsilon > 0$. In an attempt to fix the record, the present article combines the problem motivation, models, and experimental results sections from the original incorrect article with the new hardness result. We would like readers to only cite and use this version (which will remain an unpublished note) instead of the incorrect conference version.Comment: Erratum of Paper "Stability of Influence Maximization" which was presented and published in the KDD1

Vibrational Stability of NLC Linac accelerating structure

The vibration of components of the NLC linac, such as accelerating structures and girders, is being studied both experimentally and analytically. Various effects are being considered including structural resonances and vibration caused by cooling water in the accelerating structure. This paper reports the status of ongoing work.Comment: 3 pages 8 figures Presented at EPAC 2002 Paris Franc