Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug

BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses. The re-evaluation of old, forgotten drugs is a promising strategy to identify alternative anthelminthic drug candidates or drug combinations. METHODOLOGY: We studied the activity of the veterinary drug oxantel pamoate against Trichuris muris, Ancylostoma ceylanicum and Necator americanus in vitro and in vivo. In addition, the dose-effect of oxantel pamoate combined with albendazole, mebendazole, levamisole, pyrantel pamoate and ivermectin was studied against T. muris in vitro and additive or synergistic combinations were followed up in vivo. PRINCIPAL FINDINGS: We calculated an ED50 of 4.7 mg/kg for oxantel pamoate against T. muris in mice. Combinations of oxantel pamoate with pyrantel pamoate behaved antagonistically in vitro (combination index (CI) = 2.53). Oxantel pamoate combined with levamisole, albendazole or ivermectin using ratios based on their ED50s revealed antagonistic effects in vivo (CI = 1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI = 0.15) was observed when oxantel pamoate-mebendazole was administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacked activity against Ancylostoma ceylanicum and Necator americanus in vivo. CONCLUSIONSIGNIFICANCE: Our study confirms the excellent trichuricidal properties of oxantel pamoate. Since the drug lacks activity against hookworms it is necessary to combine oxantel pamoate with a partner drug with anti-hookworm properties. Synergistic effects were observed for oxantel pamoate-mebendazole, hence this combination should be studied in more detail. Since, of the standard drugs, albendazole has the highest efficacy against hookworms, additional investigations on the combination effect of oxantel pamoate-albendazole should be launche

Development of a Vessel Scheduling Optimization Model to improve Maritime Transport sustainability

The social and economic development of the islands is generally dependent on the interconnection level with the mainland obtained through maritime transport services. When connecting many islands, the route planning is essential and typically a variety of constraints must be considered. Various optimization methods have been established to improve cost-efficiency but today environmental concerns, like the reduction of CO2 emissions, have become mandatory. This paper proposes a vessel scheduling optimization model able to simultaneously consider compulsory and optional tasks and vehicle-dependent profits. The algorithm was applied to seven islands of the Tyrrhenian Sea located in front of Sicily, named “Aeolian Islands”. Considering the regional requirements in terms of minimum number of routes and maximum fare prices for each season, this research compared the optimal vessels option obtained maximizing the profit with the one obtained minimizing the emissions. In particular, we have conducted three different analyses, in the first one we have considered only the mandatory routes while the second one was carried out identifying a series of potentially attractive additional activities based on historical demand data provided by the company that currently manages the service. Finally, the third analysis addresses a scenario where older fuel-powered vessels were replaced with hybrid electric ones

Life cycle analysis of innovative building materials based on circular coffee ground supply chain

The construction sector is widely recognized as one of the most polluting mainly due to its intensive exploitation of natural resources and large energy consumption to produce traditional building materials. In the last years, alternative building materials have been developed with the aim to reduce the environmental burden of this sector. In particular, the use of geopolymer mortars as alternative cementitious materials is gaining increasing acceptance among scientists. Numerous laboratory studies demonstrate their suitability for construction applications, highlighting the potential environmental benefits that can be obtained from their large-scale production. This study aims to perform a preliminary evaluation of the environmental performance of a geopolymer mortar, whose production includes the reuse of a food waste: Spent Coffee Ground (SCG). By using the Life Cycle Assessment (LCA) approach, an environmental comparison with a traditional production of cement mortar was carried out on the basis of the Global Warming Potential (GWP) indicator

Economic and Environmental Assessment of Biomass Power Plants in Southern Italy

In 2019, Europe adopted the New Green Deal as a strategic plan to become a competitive, resource-efficient, and driven economy by reducing its gas emissions and carbon footprint. Due the COVID-19 pandemic, this strategic plan was recently updated to expedite the green transition of European industries. Therefore, the present paper deals with the problem of deciding an appropriate size for a biomass plant that directly produces electric energy by means of two different conversion processes: combustion and gasification. After an initial estimation of the energy potential in western Sicily, GIS data of biomass growth were used to identify the appropriate size for the power plants under investigation. The economic feasibility of biomass utilization was evaluated over a capacity range of 10 to 30 MW, considering total capital investments, revenues from energy sales, and total operating costs. Moreover, the effect of variations on incentive prices was analyzed by means of a sensitivity analysis. Comparing the different plant solutions considered, the environmental sustainability was also analyzed using the life cycle assessment (LCA) approach. The results showed that the combustion solution had a higher profitability and a lower environmental impact for each plant size. The obtained results also demonstrated that providing power from residual biomass in small agricultural communities would significantly reduce their environmental impacts while improving the economic feasibility of their waste management practices

Southern-Tyrrhenian seismicity in space-time-magnitude domain

An analysis is conducted on a catalogue containing more than 2000 seismic events occurred in the southern Tyrrhenian Sea between 1988 and October 2002, as an attempt to characterise the main seismogenetic processes active in the area in space, time and magnitude domain by means of the parameters of phenomenological laws. We chose to adopt simple phenomenological models, since the low number of data did not allow to use more complex laws. The two main seismogenetic volumes present in the area were considered for the purpose of this work. The first includes a nearly homogeneous distribution of hypocentres in a NW steeply dipping layer as far as about 400 km depth. This is probably the seismological expression of the Ionian lithospheric slab subducting beneath the Calabrian Arc. The second contains hypocentres concentrated about a sub-horizontal plane lying at an average depth of about 10 km. It is characterised by a background seismicity spread all over the area and by clusters of events that generally show a direction of maximum elongation. The parameters of the models describing seismogenetically homogeneous subsets of the earthquake catalogue in the three analysis domains, along with their confidence intervals, are estimated and analysed to establish whether they can be regarded as representative of a particular subset

Convective and stratiform precipitation: A PCA-based clustering algorithm for their identification

The increasing occurrence of flood events in some areas of the Southern Mediterranean area (e.g., Sicily), over the last few years, has contributed to raising the importance of characterizing such events and identifying their causes

Spatial analysis of the Italian seismic network and seismicity

Seismic networks are powerful tools for understanding active tectonic processes in a monitored region. Their numerous applications, from monitoring seismicity to characterizing seismogenic volumes and generated seismicity, make seismic networks essential tools for assessing seismic hazard in active regions. The ability to locate earthquakes hypocenters requires a seismic network with a sufficient number of optimally distributed, stations. It is important to assess existing network geometry, to identify seismogenic volumes that are not adequately monitored, and to quantify measures that will allow network improvement. In this work we have studied the spatial arrangement of the stations of the Italian National Seismic Network by means of several Point Pattern techniques The results of the point patter analysis were compare with the spatial distribution of the historical and instrument seismicity and with the distribution of the well know seismogenetic sources of the Italian peninsula. Some considerations have also been made on some models of seismic hazard of the Italian territory. Our analysis allowed us to identify some critical areas that could require an optimization of the monitoring network