Atopic dermatitis and vitamin D: facts and controversies

Patients with atopic dermatitis have genetically determined risk factors that affect the barrier function of the skin and immune responses that interact with environmental factors. Clinically, this results in an intensely pruriginous and inflamed skin that allows the penetration of irritants and allergens and predisposes patients to colonization and infection by microorganisms. Among the various etiological factors responsible for the increased prevalence of atopic diseases over the past few decades, the role of vitamin D has been emphasized. As the pathogenesis of AD involves a complex interplay of epidermal barrier dysfunction and dysregulated immune response, and vitamin D is involved in both processes, it is reasonable to expect that vitamin D's status could be associated with atopic dermatitis' risk or severity. Such association is suggested by epidemiological and experimental data. in this review, we will discuss the evidence for and against this controversial relationship, emphasizing the possible etiopathogenic mechanisms involved.Univ Brasilia UNB, Brasilia, DF, BrazilFed Dist Hlth State Dept SES DF, Brasilia, DF, BrazilUniv Brasilia HUB UNB, Brasilia Univ Hosp, Brasilia, DF, BrazilSão Paulo Fed Univ UNIFESP, Brasilia, DF, BrazilSão Paulo Fed Univ UNIFESP, Brasilia, DF, BrazilWeb of Scienc

Topical effects of SCA® (Cryptomphalus aspersa secretion) associated with regenerative and antioxidant ingredients on aged skin: evaluation by confocal and clinical microscopy

Flavia Alvim Sant’Anna Addor Clinical Research Department, Medcin Pesquisa, Osasco, Sao Paulo, Brazil Purpose: This was an open-label, single-center clinical study to evaluate a topical association of SCA® (Cryptomphalus aspersa secretion) with regenerative and antioxidant ingredients, according to the type and area of the face, on the improvement of signs of skin aging.Patients and methods: One hundred and twenty female participants aged between 40 and 65 years, with facial aging complaints (presence of static, dynamics wrinkles, loss of elasticity, and skin firmness) were randomized into two groups according to the type of skin: normal–oily and normal–dry, and 40 participants were randomized for evaluation of the periocular area (with the presence of wrinkles, expression lines, and dark circles) with both types of skin. The groups received serum for normal–oily skin, a cream for normal–dry skin, and a cream for periocular and eyelid skin (eye area). All the participants were evaluated by a dermatologist and submitted to hydration evaluation by corneometry, elasticity and firmness measures complementarily, and images were collected in confocal reflectance microscopy.Results: Topical skin treatment with the association of SCA with antioxidant ingredients (green coffee oil, olive oil, ectoine, hyaluronic acid, and peptides) was able to promote significant clinical and subjective improvement of all signs of skin aging. This improvement was presented at the epidermal level, with improved hydration levels measured by corneometry and epidermal thickness, and at the dermal level, with improvement of the firmness and elasticity parameters, measured by cutometry, from 45 days of use.Conclusion: All the evaluated topical formulations seemed to be an effective alternative for the progressive treatment of signs of skin aging, since they demonstrate a real improvement of dermal–epidermal structure and function with high safety margin for long-term use. Keywords: skin aging, confocal microscopy, photoaging, collage

Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium

Flávia Alvim Sant’Anna Addor,1 Ludmila Coelho Donato,2 Camila Sirieiro Abreu Melo2 1MEDCIN Research, Osasco, Brazil; 2Clinical Research, Farmoquímica S.A, Rio de Janeiro, Brazil Purpose: Telogen effluvium (TE) is defined as a diffuse hair loss characterized by shortening of the anagen phase and precipitation of the telogen phase, with a consequent reduction of total hair volume. Nutritional supplementation is indicated under conditions in which TE is related to dietary disorders. The aim of this clinical study was to compare the efficacy of two different supplements in monotherapy for TE.Patients and methods: Female adult patients were randomized to receive two oral nutritional supplements (group 1: a supplement composed of zinc, biotin, iron, vitamins A, C, E, and B complex, folic acid, magnesium, and amino acids of keratin and collagen and group 2: calcium pantothenate cystine, thiamine nitrate, medicinal yeast, keratin, and aminobenzoic acid) to treat hair loss for 180 days. They were evaluated clinically and by digital trichoscopy.Results: Clinical evaluation showed significant clinical improvement (P<0.05) for the evaluated parameters: hair loss, hair volume, density of hair (scalp cover), hair shine, hair strength, in 180 days. At 90 days evaluation, group 1 showed significant improvement for all parameters, while group 2 did not show any significant improvement for hair shine and hair strength. In the digital trichoscopy, there was a significant improvement only in group 1 (11.09%×7.76%) after 180 days.Conclusion: In idiopathic TE, the nutritional component should be suspected; the supplementation of an association of nutrients in recommended daily intake can lead to significant improvement of the condition from the first trimester of use. The use of an association with proven efficacy and a safety profile and posologic convenience facilitate its indication and patient adherence. Keywords: telogen effluvium, supplementation, trichoscopy, hair los

Epidemiology and Management of Acne in Adult Women

Adult acne is becoming recognized as a unique form of acne including either early (adolescent) acne that remains persistent or late onset acne. Women are predominantly affected in adult acne and will be focus of this review. The epidemiology and the characteristics of adult acne are discussed including clinical differences between adolescent and adult acne. We review topical therapies such as antibiotics, retinoids, dapsone, azelaic acid and combination-based therapies. We also review systemic therapeutic considerations, including antibiotics, isotretinoin, oral contraceptives, and hormonal modulators. We discuss the use of light-based therapies such as visible light and photodynamic therapy. Alternative therapies such as the use of botanical and phytochemical therapies are reviewed as well. Finally, we discuss the clinical and laboratory screening for considering polycystic ovarian syndrome when evaluating adult women with acne