Archaeology of Atafu, Tokelau: Some initial results from 2008

Surface survey, shovel testing, and stratigraphic excavations were done on Atafu Atoll in Tokelau during August 2008. Initial results suggest that Fale Islet has the most potential for further archaeological research. Dense cultural deposits on this islet are >1 m (39 in.) deep. Cultural material recovered includes food bone, fire-affected volcanic rock, tool-grade basalt flakes and tool fragments, Tridacna shell adzes, and pearl-shell fishhook fragments. Dog bone occurs from the earliest deposits through to the late prehistoric, while pig bone is found only in historic contexts. Fish bone is common throughout, and, with the exception of Tridacna, there are few edible mollusk remains. Initial EDXRF (Energy Dispersive X-Ray Fluorescence) analyses have found the basalt to be consistent with documented sources on Tutuila, Samoa. Basal radiocarbon dates from two excavation units are 660-540 cal. BP and 500-310 cal. BP (at 2σ)

Who are our Education Studies (Primary) concurrent students?

This project sets out to respond to a significant increase in the numbers of concurrent students in the Education Studies (Primary) Q94 pathway and the growing anecdotal evidence about the nature and motivations of these students. It aims to explore the impact on students of studying at full-time equivalent intensity (studying two 60-credit modules concurrently), building on previous university-wide studies but with greater focus on the person behind the student. By focusing on the core modules in Q94 (E103, E209, E309), the project team were able access a large cohort of students, and tutors, across levels. A mixed methods and reflexive approach has been adopted, analysing quantitative and qualitative data. The analysis was then screened through various theoretical perspectives that will help achieve a richer understanding of the data and the corresponding student narratives. To ensure a fully rounded analysis the project team has been drawn from a diverse range of staff who support students, and the students themselves. The result is a multi-layered and multi-vocal analysis that can inform how we understand students and their motivations, while also challenging preconceptions that act as barriers to a more nuanced appreciation of the student experience. The project will be used to provide guidance for qualification and module teams, tutors and student support staff to support concurrent students, as well as generate tips for students embarking on concurrent study or studying two modules concurrently. At a more fundamental level, the ‘shifting stories’ of our concurrent students have the potential to challenge institutional narratives about concurrent study and the existing frameworks of support. The project team will seek opportunities to engage in presentations and workshops to share the emerging picture of our concurrent students who are demanding to be seen as “normal” full-time HE students, with the flexibility of structures, processes and interrelationships of their ‘red-brick’ counterparts

When research seems like clinical care: a qualitative study of the communication of individual cancer genetic research results

<p>Abstract</p> <p>Background</p> <p>Research ethicists have recently declared a new ethical imperative: that researchers should communicate the results of research to participants. For some analysts, the obligation is restricted to the communication of the general findings or conclusions of the study. However, other analysts extend the obligation to the disclosure of individual research results, especially where these results are perceived to have clinical relevance. Several scholars have advanced cogent critiques of the putative obligation to disclose individual research results. They question whether ethical goals are served by disclosure or violated by non-disclosure, and whether the communication of research results respects ethically salient differences between research practices and clinical care. Empirical data on these questions are limited. Available evidence suggests, on the one hand, growing support for disclosure, and on the other, the potential for significant harm.</p> <p>Methods</p> <p>This paper explores the implications of the disclosure of individual research results for the relationship between research and clinical care through analysis of research-based cancer genetic testing in Ontario, Canada in the late 1990s. We analyze a set of 30 interviews with key informants involved with research-based cancer genetic testing before the publicly funded clinical service became available in 2000.</p> <p>Results</p> <p>We advance three insights: First, the communication of individual research results makes research practices <it>seem </it>like clinical services for our respondents. Second, while valuing the way in which research enables a form of clinical access, our respondents experience these quasi-clinical services as inadequate. Finally, our respondents recognize the ways in which their experience with these quasi-clinical services is influenced by research imperatives, but understand and interpret the significance and appropriateness of these influences in different ways.</p> <p>Conclusion</p> <p>Our findings suggest that the hybrid state created through the disclosure of research results about individuals that are perceived to be clinically relevant may produce neither sufficiently adequate clinical care nor sufficiently ethical research practices. These findings raise questions about the extent to which research can, and <it>should</it>, be made to serve clinical purposes, and suggest the need for further deliberation regarding any ethical obligation to communicate individual research results.</p

An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole-blood transcriptomics for stratification of patients with severe infection by integrating data from 3149 samples from patients with sepsis due to community-acquired pneumonia or fecal peritonitis admitted to intensive care and healthy individuals into a gene expression reference map. We used this map to derive a quantitative sepsis response signature (SRSq) score reflective of immune dysfunction and predictive of clinical outcomes, which can be estimated using a 7- or 12-gene signature. Last, we built a machine learning framework, SepstratifieR, to deploy SRSq in adult and pediatric bacterial and viral sepsis, H1N1 influenza, and COVID-19, demonstrating clinically relevant stratification across diseases and revealing some of the physiological alterations linking immune dysregulation to mortality. Our method enables early identification of individuals with dysfunctional immune profiles, bringing us closer to precision medicine in infection.peer-reviewe

Re-interpreting old dates: Radiocarbon determinations from the Tokelau Islands (South Pacific)

A re-evaluation of available archaeological radiocarbon dates from the Tokelau Islands in West Polynesia demonstrates that careful assessment is essential when developing chronologies from previously published radiocarbon data. The new calibration results point to concurrent and continual human occupation of Fakaofo and Atafu from at least 750-550 years ago up until European contact in AD 1765

Lithium aspirinate hemihydrate

The title compound {systematic name: catena-poly[ lithium(I)-mu(3)-acetylsalicylato-hemi-mu(2)-aqua]}, {[Li(C9H7O4)]center dot 0.5H(2)O}(n), is the hemihydrate of the lithium salt of aspirin. The carboxylate groups and water molecules bridge between Li atoms to form a one-dimensional coordination chain composed of two distinct ring types. The water O atom lies on a twofold axis. Hydrogen bonding between water donors and carbonyl acceptors further links the coordination chains to form a sheet structure

Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove

Aggregated states have been alluded to for many DNA minor groove binders but details of the molecule-on-molecule relationship have either been under-reported or ignored. Here we report our findings from ITC and NMR measurements carried out with AIK-18/51, a compound representative of the thiazotropsin class of DNA minor groove binders. The free aqueous form of AIK-18/51 is compared with that found in its complex with cognate DNA duplex d(CGACTAGTCG)2. Molecular self-association of AIK-18/51 is consistent with anti-parallel, face-to-face dimer formation, the building block on which the molecule aggregates. This underlying structure is closely allied to the form found in the ligand’s DNA complex. NMR chemical shift and diffusion measurements yield a self-association constant Kass = (61 ± 19) × 103 M- 1 for AIK-18/51 that fits with a stepwise self-assembly model and is consistent with ITC data. The deconstructed energetics of this assembly process are reported with respect to a design strategy for ligand/DNA recognition

Stability in the South Pacific surface marine ¹⁴C reservoir over the last 750 years. Evidence from American Samoa, the southern Cook Islands and the Marquesas

Although minor climatic and sea-level changes have been documented for the South Pacific during the late Holocene, our understanding of the consequent impact of these changes on the marine ¹⁴C reservoir, and therefore the ¹⁴C content of shellfish, is limited. Ultimately, this has implications for documenting the chronology of human movement and adaptation in this region. In this paper we compare marine reservoir (ΔR) data obtained from tightly controlled archaeological proveniences with known-age, pre-AD 1950 shells from the southern Cook Islands, American Samoa, and Marquesas Islands. Results indicate that there has been no significant change in the near-shore marine reservoir in these three locations over the last ca. 750 years. Furthermore, known-age, pre-AD 1950 shell samples provide more precise ΔR values for use in sample calibration than archaeological paired shell/charcoal samples. This is attributed in part to the limitations of assigning provenance and age to material from archaeological sites. On the basis of these results we conclude that the known-age, pre-AD 1950 shell derived ΔR values can be used to calibrate shell ¹⁴C results from deposits of late Holocene age

Stability in the South Pacific surface marine 14C reservoir over the last 750 years. Evidence from American Samoa, the southern Cook Islands and the Marquesas

Although minor climatic and sea-level changes have been documented for the South Pacific during the late Holocene, our understanding of the consequent impact of these changes on the marine 14C reservoir, and therefore the 14C content of shellfish, is limited. Ultimately, this has implications for documenting the chronology of human movement and adaptation in this region. In this paper we compare marine reservoir (ΔR) data obtained from tightly controlled archaeological proveniences with known-age, pre-AD 1950 shells from the southern Cook Islands, American Samoa, and Marquesas Islands. Results indicate that there has been no significant change in the near-shore marine reservoir in these three locations over the last ca. 750 years. Furthermore, known-age, pre-AD 1950 shell samples provide more precise ΔR values for use in sample calibration than archaeological paired shell/charcoal samples. This is attributed in part to the limitations of assigning provenance and age to material from archaeological sites. On the basis of these results we conclude that the known-age, pre-AD 1950 shell derived ΔR values can be used to calibrate shell 14C results from deposits of late Holocene age. Crow