Assessing Oral Health Knowledge and Practices: A Study of Mothers and Children in Northwestern Nigeria

Purpose – To explore the knowledge, attitude, and practices regarding oral and dental health for mothers of children aged 6 months to 8 years and older children aged above 8 years to 15 years seeking healthcare in a tertiary health facility in the Sokoto metropolis. Design/methods/approach – A cross-sectional study was conducted between February and April 2022. Subjects included mothers of 6 months to < 8 years and children aged 8 to 15 years presenting with minor illnesses to the General outpatient clinic. A structured questionnaire and focus group discussion guide were used to collect the information. Data was analyzed using IBM SPSS version 25. Findings – Out of 238 participants, 128 children were 6 months to <8 years, while 110 were above 8 to 15 years old. Less than half of mothers, 46.9%, had inadequate knowledge, while 20.3% had adequate practices. Among the older children in this study, the proportion of those with good knowledge, attitude, and practice level of oral health was 60%, 61.8%, and 32.7%. There was a significant moderate positive correlation between knowledge and attitude scores but not practice for the 2 groups. Mothers’ education and fathers’ occupation were significantly related to good scores (p=<0.05). Mothers of children with primary teeth and older children with permanent teeth in this study all had poor oral and dental health practices. More awareness programs should be conducted in the community to target those with poor practices. Increasing female education and empowerment is also essential in this regard. Research implications/limitations – This research implies that from an early age, it is necessary to check oral and dental health to prevent infectious diseases. Originality/value – Oral and dental health is an essential aspect of primary health care and is a situation in which the mouth, teeth, and gums are healthy and free from any diseases. Parents, especially mothers, are responsible for maintaining good oral hygiene practices and inculcating good oral hygiene habits in children. Paper Type Research paper

Prevalence, clinical profile and outcome of children with cardiomyopathy

Background: Cardiomyopathies are myocardial disorders in which the heart muscle is structurally and functionally abnormal, thereby affecting the ventricular systolic function and/or diastolic function. Comprehensive approach to management warrants recognizing the clinical profile in order to strategize to improve outcomes. Aim: To evaluate the types of cardiomyopathies, presentation and outcome among children admitted into a tertiary hospital in Sokoto. Methods. A hospital based prospective study of children aged below 15 years who were seen over an 8.5-year period. A proforma was used to collect the information on their socio-demographics, type of cardiomyopathy, associated presentations and outcome. Data was analysed using IBM SPSS version 25. Results: 71 out of 78,321 children seen that period (0.1%) were diagnosed with CM giving a hospital prevalence of 90.7/100,000. They comprised 40 (56.3%) males and 31 (43.7%) females. Age ranged from 1 month to 15 years (6.2 ± 3.8 years). Dilated CM (DCM) was the commonest in 63 (88.7%), restrictive CM (endomyocardial fibrosis-EMF) in 5 (7.0%) and hypertrophic (HCM) in 3 (4.2%). Forty-six (73%) of DCM had severe systolic dysfunction. DCM also occurred in 2 siblings of 2 patients on follow up. Two of the patients with EMF had recurrent pericardial effusions and all the patients with HCM died in infancy. Thirty (42.2%) of the total patients were lost to follow-up while 27 (38.0%) died. Conclusion: Dilated cardiomyopathy followed by restrictive type are the commonest types seen among children in Sokoto. It is associated with high morbidity and mortality

Larval density and physicochemical properties of three different breeding habitats of Anopheles mosquitoes in Sudan Savannah Region of Jigawa State, Nigeria

Mosquitoes are tiny insects that can serve as vectors for numerous infectious diseases like malaria. Malaria is considered as one of the major causes of mortality, loss of productivity and a major contributor of poverty in the African continent. In 2020, most global malaria cases (94%) were recorded in the Africa Region. In Nigeria, about 97% of the estimated populations are at risk of malaria, with up to 27% and 24% of Africa and global malaria deaths respectively in 2018. Malaria control programmes in Africa have challenge of rising insecticide resistance in the main anopheline vectors, this affects primary malaria vector control interventions. In Africa, the dominant mosquito species that transmit malaria parasites are mainly Anopheles gambiae s.s. A key control strategy against major mosquito- borne diseases involves targeting mosquito vectors to disrupt the transmission of diseases. Environmental changes can alter the genetic structure, protein profiles and enzymes of mosquitoes leading to increase in insecticide resistance. Knowing the ecology, spatial distribution of mosquito larvae, and some environmental features like physicochemical factors are important in tackling insecticide resistance. Water and larval samples were collected from three Anopheles mosquito breeding sites in August, September and October, 2019. Physicochemical parameters, larval densities and morphological specie identifications were determined. Results from this study reveal variation in levels of each studied parameter according to the site of the study. These variations can be attributed to differences in activities that occur in each site of the study.. Correlation studies indicated a significantly higher larval density in agricultural site relative to industrial and residential sites, this was by a magnitude of 10.65 and 41.30 respectively. Anopheles gambiae s.s. complex was found to be predominant in all the three study sites. These physicochemical parameters can either have negative or positive effect on mosquito biology depending on their levels, hence can affect vector control measures making it significant in terms of vector control programmes

Uncovering the inhibitory potentials of <i>Phyllanthus nivosus</i> leaf and its bioactive compounds against Plasmodium lactate dehydrogenase for malaria therapy

Malaria control efforts have been hampered due to the emergence of resistant malaria parasite strains and the coinciding events of Covid-19. The quest for more effective and safe treatment alternatives is driving a slew of new studies that must be accelerated if malaria can be overcome. Due to its reported antimalarial activity, we studied the effects of extract and fractions of Phyllanthus nivosus leaf on Plasmodium lactate dehydrogenase (pLDH) activity using an in vitro assay. This was followed by an anti-plasmodial study using Plasmodium berghei-infected mice and an in silico identification of the plant’s phytochemicals with possible pLDH-inhibitory activity. The activity of pLDH was significantly reduced in the presence of ethanol extract and various solvent fractions of Phyllanthus nivosus leaf, with the ethyl acetate fraction having the best inhibitory activity, which was comparable to that of the standard drug (chloroquine). The ethyl acetate fraction at 100 and 200 mg/Kg also suppressed the parasitaemia of Plasmodium berghei-infected mice by 76 and 80% respectively. Among the 53 compounds docked against pLDH, (-)-alpha-Cadinol, (+)-alpha-phellandrene, and spathulenol, all terpenes from the ethyl acetate fraction of P. nivosus leaf extract, demonstrated docking scores comparable to that of chloroquine. The three chemicals, like chloroquine, displayed important molecular interactions with the amino acid residues of the enzyme’s NADH-binding site. According to the in silico ADMET study, the three terpenes have suitable drug-like abilities, pharmacokinetic features, and safety profiles. Hence, they could be considered for further development as antimalarial drugs. Communicated by Ramaswamy H. Sarma</p