Aging-induced stem cell mutations as drivers for disease and cancer

Aging is characterized by a decrease in genome integrity, impaired organ maintenance, and an increased risk of cancer, which coincide with clonal dominance of expanded mutant stem and progenitor cell populations in aging tissues, such as the intestinal epithelium, the hematopoietic system, and the male germline. Here we discuss possible explanations for age-associated increases in the initiation and/or progression of mutant stem/progenitor clones and highlight the roles of stem cell quiescence, replication-associated DNA damage, telomere shortening, epigenetic alterations, and metabolic challenges as determinants of stem cell mutations and clonal dominance in aging

What would Stradivari have to have done to receive a DProf by Public Works?

Extended Abstract prepared for the 4th International Conference on Professional Doctorates, Millennium Centre, Cardiff, April 2014 to be developed into a full paper to be published in a refereed journal

Measurement of the Transverse Single Spin Asymmetry of pp + p↑p^\uparrow →\rightarrow η\eta + XX at s\sqrt{s} = 200 GeV

The measurement of transverse single spin asymmetries ($A_N$) provides insight into the structure of the nucleon. Several mechanisms have been proposed that attempt to explain $A_N$ based on QCD, and additional measurements of $A_N$ for different processes further constrain these models. Using the PHENIX detector at the Relativistic Heavy Ion Collider (RHIC), we study transversely polarized p+p collisions. Results from PHENIX and other experiments show significant asymmetries in the forward region, which could be due to contributions from both the Sivers and the Collins effects. Studying the species as well as the kinematic dependencies of these transverse single spin asymmetries will help to disentangle the origin of the observed asymmetries. Therefore, measurements of $A_N$ with inclusive $\eta$ mesons at forward rapidities are an important tool for the understanding of these asymmetries. In 2008, the PHENIX experiment collected 5.2 pb$^{-1}$ integrated luminosity in $p^\uparrow+p$ collisions at $\sqrt{s}$ = 200 GeV. The status of the asymmetry analysis of $\eta$ mesons at forward rapidity will be shown.Comment: 4 pages, 3 figure

Experimental comparison of icing cloud instruments

Icing cloud instruments were tested in the spray cloud Icing Research Tunnel (IRT) in order to determine their relative accuracy and their limitations over a broad range of conditions. It was found that the average of the readings from each of the liquid water content (LWC) instruments tested agreed closely with each other and with the IRT calibration; but all have a data scatter (+ or - one standard deviation) of about + or - 20 percent. The effect of this + or - 20 percent uncertainty is probably acceptable in aero-penalty and deicer experiments. Existing laser spectrometers proved to be too inaccurate for LWC measurements. The error due to water runoff was the same for all ice accretion LWC instruments. Any given laser spectrometer proved to be highly repeatable in its indications of volume median drop size (DVM), LWC and drop size distribution. However, there was a significant disagreement between different spectrometers of the same model, even after careful standard calibration and data analysis. The scatter about the mean of the DVM data from five Axial Scattering Spectrometer Probes was + or - 20 percent (+ or - one standard deviation) and the average was 20 percent higher than the old IRT calibration. The + or - 20 percent uncertainty in DVM can cause an unacceptable variation in the drag coefficient of an airfoil with ice; however, the variation in a deicer performance test may be acceptable

The Design and Validation of the Colorado Learning Attitudes about Science Survey

The Colorado Learning Attitudes about Science Survey (CLASS) is a new instrument designed to measure various facets of student attitudes and beliefs about learning physics. This instrument extends previous work by probing additional facets of student attitudes and beliefs. It has been written to be suitably worded for students in a variety of different courses. This paper introduces the CLASS and its design and validation studies, which include analyzing results from over 2400 students, interviews and factor analyses. Methodology used to determine categories and how to analyze the robustness of categories for probing various facets of student learning are also described. This paper serves as the foundation for the results and conclusions from the analysis of our survey dat

Results on the nucleon spin structure

SMC performed an investigation of the spin structure of the nucleon by measuring deep inelastic scattering of polarised muons off polarised protons and deuterons. A summary of the results for spin structure functions and sum rules is given.Comment: 8 pages, LaTeX, Talk given at the Workshop on "Symmetry and Spin - PRAHA98", Prag, September 1998. Proceedings to be published by Czech. Journ. Phy

Correlating Student Beliefs With Student Learning Using The Colorado Learning Attitudes about Science Survey

A number of instruments have been designed to probe the variety of attitudes, beliefs, expectations, and epistemological frames taught in our introductory physics courses. Using a newly developed instrument -- the Colorado Learning Attitudes about Science Survey (CLASS)[1] -- we examine the relationship between students' beliefs about physics and other educational outcomes, such as conceptual learning and student retention. We report results from surveys of over 750 students in a variety of courses, including several courses modified to promote favorable beliefs about physics. We find positive correlations between particular student beliefs and conceptual learning gains, and between student retention and favorable beliefs in select categories. We also note the influence of teaching practices on student beliefs

Towards characterizing the relationship between students' interest in and their beliefs about physics

We examine the relationships between students' self-reported interest and their responses to a physics beliefs survey. Results from the Colorado Learning Attitudes about Science Survey (CLASS v3), collected in a large calculusbased introductory mechanics course (N=391), were used to characterize students' beliefs about physics and learning physics at the beginning and end of the semester. Additionally students were asked at the end of the semester to rate their interest in physics, how it has changed, and why. We find a correlation between surveyed beliefs and self-rated interest (R=0.65). At the end of the term, students with more expert-like beliefs as measured by the 'Overall' CLASS score also rate themselves as more interested in physics. An analysis of students' reasons for why their interest changed showed that a sizable fraction of students cited reasons tied to beliefs about physics or learning physics as probed by the CLASS survey. The leading reason for increased interest was the connection between physics and the real world

STUDIES ON ABLATION OF OBJECTS TRAVERSING AN ATMOSPHERE

Ablation-type thermal protection of objects traversing an atmosphere - earth and mar

Coarsening of "clouds" and dynamic scaling in a far-from-equilibrium model system

A two-dimensional lattice gas of two species, driven in opposite directions by an external force, undergoes a jamming transition if the filling fraction is sufficiently high. Using Monte Carlo simulations, we investigate the growth of these jams ("clouds"), as the system approaches a non-equilibrium steady state from a disordered initial state. We monitor the dynamic structure factor $S(k_x,k_y;t)$ and find that the $k_x=0$ component exhibits dynamic scaling, of the form $S(0,k_y;t)=t^\beta \tilde{S}(k_yt^\alpha)$. Over a significant range of times, we observe excellent data collapse with $\alpha=1/2$ and $\beta=1$. The effects of varying filling fraction and driving force are discussed