1,707 research outputs found

    Correction: Multi-layer 3D printed dipeptide-based low molecular weight gels

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    On slip pulses at a sheared frictional viscoelastic/ non deformable interface

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    We study the possibility for a semi-infinite block of linear viscoelastic material, in homogeneous frictional contact with a non-deformable one, to slide under shear via a periodic set of ``self-healing pulses'', i.e. a set of drifting slip regions separated by stick ones. We show that, contrary to existing experimental indications, such a mode of frictional sliding is impossible for an interface obeying a simple local Coulomb law of solid friction. We then discuss possible physical improvements of the friction model which might open the possibility of such dynamics, among which slip weakening of the friction coefficient, and stress the interest of developing systematic experimental investigations of this question.Comment: 23 pages, 3 figures. submitted to PR

    Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a murine model driven by activated NRAS and Wnt signaling

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    Congenital melanocytic nevus (CMN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous system, most frequently caused by a mutation of NRAS codon 61. This condition is currently untreatable and carries a significant risk of melanoma within the skin, brain, or leptomeninges. We have previously proposed a key role for Wnt signaling in the formation of melanocytic nevi, suggesting that activated Wnt signaling may be synergistic with activated NRAS in the pathogenesis of CMN syndrome. Some familial pre-disposition suggests a germ-line contribution to CMN syndrome, as does variability of neurological phenotypes in individuals with similar cutaneous phenotypes. Accordingly, we performed exome sequencing of germ-line DNA from patients with CMN to reveal rare or undescribed Wnt-signaling alterations. A murine model harboring activated NRASQ61K and Wnt signaling in melanocytes exhibited striking features of CMN syndrome, in particular neurological involvement. In the first model of treatment for this condition, these congenital, and previously assumed permanent, features were profoundly suppressed by acute post-natal treatment with a MEK inhibitor. These data suggest that activated NRAS and aberrant Wnt signaling conspire to drive CMN syndrome. Post-natal MEK inhibition is a potential candidate therapy for patients with this debilitating condition

    Can one written word mean many things? Prereaders’ assumptions about the stability of written words’ meanings

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    Results of three experiments confirmed previous findings that in a moving word task, prereaders 3 to 5 years of age judge as if the meaning of a written word changes when it moves from a matching to a nonmatching toy (e.g., when the word “dog” moves from a dog to a boat). We explore under what circumstances children make such errors, we identify new conditions under which children were more likely correctly to treat written words’ meanings as stable: when the word was placed alongside a nonmatching toy without having been alongside a matching toy previously, when two words were moved from a matching toy to a nonmatching toy, and when children were asked to change what the print said. Under these conditions, children more frequently assumed that physical forms had stable meanings as they do with other forms of external representation

    Superfluid Spin-down, with Random Unpinning of the Vortices

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    The so-called ``creeping'' motion of the pinned vortices in a rotating superfluid involves ``random unpinning'' and ``vortex motion'' as two physically separate processes. We argue that such a creeping motion of the vortices need not be (biased) in the direction of an existing radial Magnus force, nor should a constant microscopic radial velocity be assigned to the vortex motion, in contradiction with the basic assumptions of the ``vortex creep'' model. We point out internal inconsistencies in the predictions of this model which arise due to this unjustified foundation that ignores the role of the actual torque on the superfluid. The proper spin-down rate of a pinned superfluid is then calculated and turns out to be much less than that suggested in the vortex creep model, hence being of even less observational significance for its possible application in explaining the post-glitch relaxations of the radio pulsars.Comment: To be published in J. Low Temp. Phys., Vol. 139, May 2005 [Eqs 11, 15-17 here, have been revised and, may be substituted for the corresponding ones in that paper

    Scintillation and charge extraction from the tracks of energetic electrons in superfluid helium-4

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    An energetic electron passing through liquid helium causes ionization along its track. The ionized electrons quickly recombine with the resulting positive ions, which leads to the production of prompt scintillation light. By applying appropriate electric fields, some of the ionized electrons can be separated from their parent ions. The fraction of the ionized electrons extracted in a given applied field depends on the separation distance between the electrons and the ions. We report the determination of the mean electron-ion separation distance for charge pairs produced along the tracks of beta particles in superfluid helium at 1.5 K by studying the quenching of the scintillation light under applied electric fields. Knowledge of this mean separation parameter will aid in the design of particle detectors that use superfluid helium as a target material.Comment: 10 pages, 8 figure

    Variational Approach to Hydrogen Atom in Uniform Magnetic Field of Arbitrary Strength

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    Extending the Feynman-Kleinert variational approach, we calculate the temperature-dependent effective classical potential governing the quantum statistics of a hydrogen atom in a uniform magnetic at all temperatures. The zero-temperature limit yields the binding energy of the electron which is quite accurate for all magnetic field strengths and exhibits, in particular, the correct logarithmic growth at large fields.Comment: Author Information under this http://www.physik.fu-berlin.de/~kleinert/institution.html Latest update of paper also at this http://www.physik.fu-berlin.de/~kleinert/30

    Neural correlates of economic game playing

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    The theory of games provides a mathematical formalization of strategic choices, which have been studied in both economics and neuroscience, and more recently has become the focus of neuroeconomics experiments with human and non-human actors. This paper reviews the results from a number of game experiments that establish a unitary system for forming subjective expected utility maps in the brain, and acting on these maps to produce choices. Social situations require the brain to build an understanding of the other person using neuronal mechanisms that share affective and intentional mental states. These systems allow subjects to better predict other players' choices, and allow them to modify their subjective utility maps to value pro-social strategies. New results for a trust game are presented, which show that the trust relationship includes systems common to both trusting and trustworthy behaviour, but they also show that the relative temporal positions of first and second players require computations unique to that role
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