100 research outputs found
Bells of Saint Mary\u27s
Get PDFThe bells of St. Marry\u27s at sweet eventide,Shall call me beloved, to come to your side,And out in the valley in south of the sea, I know you\u27ll be waiting, yes waiting for me.
RefrainThe Bells of St. Mary\u27s,Ah! hear they are callingThe young loves-- true lovesWho come from the sea,And so my beloved,When red leaves are falling,The Love-bells shall ring out- ring outFor you and me.The Bells of St. Mary\u27s, Ah! hear they are callingThe young loves- the true lovesWho come from the sea,And so, my beloved,When red leaves are falling,The love-bells shall ring out- ring outFor you and me.
At the porch of St. Mary\u27s I\u27ll wait there with youIn your soft wedding dress with its ribbons of blue,in the church of St. Mary\u27s sweet voices shall sing,For you and me dearest the wedding bells ring.(to Refrain
Unique domain appended to vertebrate tRNA synthetase is essential for vascular development
Get PDFNew domains were progressively added to cytoplasmic aminoacyl transfer RNA (tRNA) synthetases during evolution. One example is the UNE-S domain, appended to seryl-tRNA synthetase (SerRS) in species that developed closed circulatory systems. Here we show using solution and crystal structure analyses and in vitro and in vivo functional studies that UNE-S harbours a robust nuclear localization signal (NLS) directing SerRS to the nucleus where it attenuates vascular endothelial growth factor A expression. We also show that SerRS mutants previously linked to vasculature abnormalities either deleted the NLS or have the NLS sequestered in an alternative conformation. A structure-based second-site mutation, designed to release the sequestered NLS, restored normal vasculature. Thus, the essential function of SerRS in vascular development depends on UNE-S. These results are the first to show an essential role for a tRNA synthetase-associated appended domain at the organism level, and suggest that acquisition of UNE-S has a role in the establishment of the closed circulatory systems of vertebrates
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Population-based analysis of POT1 variants in a cutaneous melanoma case–control cohort
Get PDFArticle describes how pathogenic germline variants in the protection of telomeres 1 gene (POT1) have been associated with predisposition to a range of tumor types, including melanoma, glioma, leukemia and cardiac angiosarcoma. The authors sequenced all coding exons of the POT1 gene in 2928 European-descent melanoma cases and 3298 controls, identifying 43 protein-changing genetic variants
What’s retinoic acid got to do with it? Retinoic acid regulation of the neural crest in craniofacial and ocular development
Full text linkPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151310/1/dvg23308.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151310/2/dvg23308_am.pd
Increased Incidence of Vestibular Disorders in Patients With SARS-CoV-2
Get PDFOBJECTIVE: Determine the incidence of vestibular disorders in patients with SARS-CoV-2 compared to the control population.
STUDY DESIGN: Retrospective.
SETTING: Clinical data in the National COVID Cohort Collaborative database (N3C).
METHODS: Deidentified patient data from the National COVID Cohort Collaborative database (N3C) were queried based on variant peak prevalence (untyped, alpha, delta, omicron 21K, and omicron 23A) from covariants.org to retrospectively analyze the incidence of vestibular disorders in patients with SARS-CoV-2 compared to control population, consisting of patients without documented evidence of COVID infection during the same period.
RESULTS: Patients testing positive for COVID-19 were significantly more likely to have a vestibular disorder compared to the control population. Compared to control patients, the odds ratio of vestibular disorders was significantly elevated in patients with untyped (odds ratio [OR], 2.39; confidence intervals [CI], 2.29-2.50;
CONCLUSIONS: The incidence of vestibular disorders differed between COVID-19 variants and was significantly elevated in COVID-19-positive patients compared to the control population. These findings have implications for patient counseling and further research is needed to discern the long-term effects of these findings
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