Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1 alpha

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordThe mammalian circadian system consists of a master clock in the brain that synchronizes subsidiary oscillators in peripheral tissues. The master clock maintains phase coherence in peripheral cells through systemic cues such as feeding-fasting and temperature cycles. Here, we examined the role of oxygen as a resetting cue for circadian clocks. We continuously measured oxygen levels in living animals and detected daily rhythms in tissue oxygenation. Oxygen cycles, within the physiological range, were sufficient to synchronize cellular clocks in a HIF1α-dependent manner. Furthermore, several clock genes responded to changes in oxygen levels through HIF1α. Finally, we found that a moderate reduction in oxygen levels for a short period accelerates the adaptation of wild-type but not of HIF1α-deficient mice to the new time in a jet lag protocol. We conclude that oxygen, via HIF1α activation, is a resetting cue for circadian clocks and propose oxygen modulation as therapy for jet lag.Israel Science FoundationEuropean Research CouncilFeinberg Graduate School, Weizmann Institute of ScienceBritish Heart FoundationEuropean Union, Seventh Framework Programm

The leading particle effect from light quark fragmentation in charm hadroproduction

The asymmetry of $D^-$ and $D^+$ meson production in $\pi^-N$ scattering observed by the E791 experiment is a typical phenomenon known as the leading particle effect in charm hadroproducton. We show that the phenomenon can be explained by the effect of light quark fragmentation into charmed hadrons (LQF). Meanwhile, the size of the LQF effect is estimated from data of the E791 experiment. A comparison is made with the estimate of the LQF effect from prompt like-sign dimuon rate in neutrino experiments. The influence of the LQF effect on the measurement of nucleon strange distribution asymmetry from charged current charm production processes is briefly discussed.Comment: 6 latex pages, 1 figure, to appear in EPJ

Reduction of airborne particulate matter emissions associated with petroleum coke production

This article presents the results of studies on production based on products of secondary oil refining processes of agents for dust suppression and reduction of losses from blowing out of wet bulk carbon-containing materials, in particular petroleum coke, as well as against freezing and adhesion during their transportation at low temperatures. The use of the developed dust suppression-antifreeze agent will reduce exposure to dust of the employees at the delayed coking unit in the course of petroleum coke production and improve its freeze resistance. It will have a positive impact on the solution of the problem of petroleum coke transportation at subzero temperatures, and will also allow expanding the range of marketable products, and increasing production efficiency

Flow and Noise Control in High Speed and High Reynolds Number Jets Using Plasma Actuators

The idea of manipulating flow to change its characteristics is over a century old. Manipulating instabilities of a jet to increase its mixing and to reduce its radiated noise started in the 1970s. While the effort has been successful in low-speed and low Reynolds number jets, available actuators capabilities in terms of their amplitude, bandwidth, and phasing have fallen short in control of high-speed and high Reynolds number jets of practical interest. Localized arc filament plasma actuators have recently been developed and extensively used at Gas Dynamics and Turbulence Laboratory (GDTL) for control of highspeed and high Reynolds number jets. While the technique has been quite successful and is very promising, all the work up to this point had been carried out using small high subsonic and low supersonic jets from a 2.54 cm diameter nozzle exit with a Reynolds number of about a million. The preliminary work reported in this paper is a first attempt to evaluate the scalability of the technique. The power supply/plasma generator was designed and built in-house at GDTL to operate 8 actuators simultaneously over a large frequency range (0 to 200 kHz) with independent control over phase and duty cycle of each actuator. This allowed forcing the small jet at GDTL with azimuthal modes m = 0, 1, 2, 3, plus or minus 1, plus or minus 2, and plus or minus 4 over a large range of frequencies. This power supply was taken to and used, with minor modifications, at the NASA Nozzle Acoustic Test Rig (NATR). At NATR, 32 actuators were distributed around the 7.5 in. nozzle (a linear increase with nozzle exit diameter would require 60 actuators). With this arrangement only 8 actuators could operate simultaneously, thus limiting the forcing of the jet at NATR to only three azimuthal modes m = plus or minus 1, 4, and 8. Very preliminary results at NATR indicate that the trends observed in the larger NASA facility in terms of the effects of actuation frequency and azimuthal modes are similar in both small GDTL and larger NASA jets. However, the actuation authority seems to fall short in the larger jet at higher Mach numbers, resulting in decreased amplitude response compared to the small jet, which is attributed at this point to the lack of sufficient number of actuators. The preliminary results seem also to suggest that amplitude of actuation tones is similar in both the small and larger jets

Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals

This is the author accepted manuscript. The final version is available from Elsevier (Cell Press).Daily rhythms in animal physiology are driven by endogenous circadian clocks in part through rest-activity and feeding-fasting cycles. Here, we examined principles that govern daily respiration. We monitored oxygen consumption and carbon dioxide release, as well as tissue oxygenation in freely moving animals to specifically dissect the role of circadian clocks and feeding time on daily respiration. We found that daily rhythms in oxygen and carbon dioxide are clock controlled and that time-restricted feeding restores their rhythmicity in clock-deficient mice. Remarkably, day-time feeding dissociated oxygen rhythms from carbon dioxide oscillations, whereby oxygen followed activity, and carbon dioxide was shifted and aligned with food intake. In addition, changes in carbon dioxide levels altered clock gene expression and phase shifted the clock. Collectively, our findings indicate that oxygen and carbon dioxide rhythms are clock controlled and feeding regulated and support a potential role for carbon dioxide in phase resetting peripheral clocks upon feeding.British Heart FoundationEuropean Research CouncilEuropean Union, Seventh Framework Program, Marie Curie Action

Ligand design and preparation, photophysical properties, and device performance of an encapsulated-type pseudo-tris(heteroleptic) iridium(iii) emitter

The organic molecule 2-(1-phenyl-1-(pyridin-2-yl)ethyl)-6-(3-(1-phenyl-1-(pyridin-2-yl)ethyl)phenyl)pyridine (H3L) has been designed, prepared, and employed to synthesize the encapsulated-type pseudo-tris(heteroleptic) iridium(III) derivative Ir(κ6-fac-C,C′,C″-fac-N,N′,N″-L). Its formation takes place as a result of the coordination of the heterocycles to the iridium center and the ortho-CH bond activation of the phenyl groups. Dimer [Ir(μ-Cl)(η4-COD)]2 is suitable for the preparation of this compound of class [Ir(9h)] (9h = 9-electron donor hexadentate ligand), but Ir(acac)3 is a more appropriate starting material. Reactions were carried out in 1-phenylethanol. In contrast to the latter, 2-ethoxyethanol promotes the metal carbonylation, inhibiting the full coordination of H3L. Complex Ir(κ6-fac-C,C′,C″-fac-N,N′,N″-L) is a phosphorescent emitter upon photoexcitation, which has been employed to fabricate four yellow emitting devices with 1931 CIE (x:y) ∼ (0.52:0.48) and a maximum wavelength at 576 nm. These devices display luminous efficacies, external quantum efficiencies, and power efficacies at 600 cd m–2, which lie in the ranges 21.4–31.3 cd A–1, 7.8–11.3%, and 10.2–14.1 lm W1–, respectively, depending on the device configuration

Heavy to Light Meson Exclusive Semileptonic Decays in Effective Field Theory of Heavy Quark

We present a general study on exclusive semileptonic decays of heavy (B, D, B_s) to light (pi, rho, K, K^*) mesons in the framework of effective field theory of heavy quark. Transition matrix elements of these decays can be systematically characterized by a set of wave functions which are independent of the heavy quark mass except for the implicit scale dependence. Form factors for all these decays are calculated consistently within the effective theory framework using the light cone sum rule method at the leading order of 1/m_Q expansion. The branching ratios of these decays are evaluated, and the heavy and light flavor symmetry breaking effects are investigated. We also give comparison of our results and the predictions from other approaches, among which are the relations proposed recently in the framework of large energy effective theory.Comment: 18 pages, ReVtex, 5 figures, added references and comparison of results, and corrected signs in some formula

«SAFE LEADER» IN THE FIELD OF LABOR PROTECTION

Определено, что в настоящее время возникает необходимость выделить особый вид лидера – «безопасного», который способен на своем примере показать приверженность и значимость соблюдения требований охраны труда, и как следствие повысить уровень культуры безопасности на производстве.= Nowadays there is a need to single out a special type of leader - “safe”. A safe leader is able to demonstrate by his own example the commitment and importance of compliance with labor protection requirements and increase the level of safety culture at work. Keywords: labor safety, leader, safe leader

THE ROLE OF THE "SAFE LEADER" IN ENSURING PROFESSIONAL SAFETY

Определено, что в настоящее время возникает необходимость выделить особый вид лидера – «безопасного», который способен на своем примере показать приверженность и значимость соблюдения требований охраны труда, и как следствие повысить уровень культуры безопасности на производстве.= Nowadays there is a need to single out a special type of leader - “safe”. A safe leader is able to demonstrate by his own example the commitment and importance of compliance with labor protection requirements and increase the level of safety culture at work