The results of postoperative radiotherapy in patients with renal cell carcinoma in third stage of clinical advancement based on data of Greatpoland Cancer Centre

The role of complementary radiotherapy in patients with stage III renal cell carcinoma after radical nephrectomy still remains a matter of discussion. In connection with lack of alternative solutions the treatment is still conducted in many centres. In Greatpoland Cancer Centre in period 1985–1991 complementary radiotherapy was carried out in 169 patients with infiltration of adipose capsule and/or renal stalk or metastases in closest lymph nodes confirmed during operation.The patients were irradiated from two opposite fields including a bed of the removed kidney and regional lymph nodes. Total dose amounted 50 Gy (25 fractions), 2 Gy daily, five times a week.Early complications after radiotherapy like lack of appetite, diarrhoea and moderate leucopenia, disappearing after pharmacologhical treatment, were observed in 20% of patients and did not cause interruption in treatment. No late complications were observed.5-year survival without recurrence was achieved in 47% of thease patients. In the whole group only four local recurrences were found. The reasons of treatment failure were distant metastases. We proved that teleradiotherapy turned out to be efficient method protecting against local recurrence of disease but did not influence significantly 5-year survival rate

69 Wstępna ocena wyników leczenia oszczędzającego w latach 1993–1995 w Wielkopolskim Centrum Onkologii

W latach 1993–1995 w Wielkopolskim Centrum Onkologii leczonych było metodą oszczędzającą gruczoł piersiowy 66 kobiet. Wiek chorych wahał się od 28–73 lat, średni 40,8. Do leczenia były kwalifikowane chore z guzem w piersi do 3 cm i niepalpacyjnymi węzłami pachowymi. Nowotwór u 37 chorych zlokalizowany był w piersi prawej, u 29 w piersi lewej. Najczęściej był umiejscowiony w kwadracie górnym zewnętrznym. W 53 przypadkach stwierdzono raka przewodowego, 4 DCIS, 4 molekularnego, 7 zrazikowego.U 18 pacjentek stwierdzono w ocenie histologicznej przerzuty w węzłach dołu pachowego. Okres obserwacji naszych chorych jest jeszcze stosunkowo krótki. Wśród naszych pacjentek u 4 powodu wznowy miejscowej konieczne mastectomii, 3 kobiety zmarły z powodu przerzutów odległych (jedna w 1 roku obserwacji, dwie w 2 roku obserwacji)

The results of breast conservative therapy in early breast cancer in Greatpoland Cancer Centre

We are presenting results of our treatment during 3 years (1993–1995) in Greatpoland Cancer Centre.We treated 67 women with early breast cancer performing breast conservative surgery and radiation therapy. For treatment we chose women with breast tumor up to 3 cm in diameter and unpalpable axillary lymph nodes. The therapy consisted of quadrantectomy and axillary dissection and then radiation therapy.Chemotherapy was used for patients with histologically positive lymph nodes metastases. Due to the local recurrence the mastectomy was performed in four patients. Five women were treated with cytostatics because of metastases to the liver and bones.Three women died. The other women remain in the periodical observation in our hospital. These results have a preliminary character, because of the short follow up

58. Influence of total time of surgery and postoperative radiotherapy on the outcome patients with advanced laryngeal carcinoma

AimTo evaluate influence of total time of combined treatment on locoregional outcome of treatment in group patients with larynx cancer.Material/MethodsWe performed retrospective analysis of 254 patients with with stage III or IV squamous cell carcinoma of larynx who were treated between 1993 and 1996. There were 236 men, 18 women, median age was 56.3 years. Surgery consisted of total laryngectomy and elective/selective neck dissection. Patients postoperativly were irradiated in coventional way with total dose of 60 Gy. We used shrinking field technique with lateral opposed photon fields to tumor bed and upper-mid neck nodes. Supraclavicular regions (lower neck lymph nodes) were treated with an anterior field. Total time of combined treatment (from the surgery to the end of radiotherapy) was an average 92 days (range, 65–131 days). The interval between surgery and the beginning of radiotherapy was an average 45 days (range, 22–78 days) and time of irradiation was an average 45 day (range, 40–74 days).ResultsProlongation overall time of combined treatment beyond 90 days is strongly correlated with decreasing of locoregional outcome of treatment (p=0.00036). Also decreasing in outcome of treatment was noted when interval time between surgery and beginning of radiotherapy was more than 50 days (p=0.022) and when the time of irradiation was longer than 44 days (p=0.0026).ConclusionsDecreasing of total time of combined treatment (surgery and postoperative radiotherapy) is crucial in patients with advanced cancer of larynx

91. Early toxicity in 3 D CRT of lung cancer

AimEvaluation the influence of irradiated volume of lung on pneumonitis in 3D radiotherapy.Material/methods and ResultsWe evaluated 49 patients with diagnosis of non-small-cell lung cancer (NSCLC) who were treated in our department between 1999 and 2000. The mean age of patinets was 62 years. The Karnofsky index was documented in all patients before, during and after completion of irradiation. All patients represented IIIA clinical stage of lung cancer. Fourteen patients were irradiated postoperatively due to the residual tumour or massive nodal involvment. Thirty five patients were treated with exclusive radiotherapy. No patients have been treated by chemotherapy. We performed 3D CRT with total dose in range 60 to 66 Gy in daily fractions of 2 Gy prescribed to isocentric point. Clinical and radiological evaluation of pneumonitis was performed. 21 patients of 49 had radiation pneumonitis, but intensity of pneumonitis was moderate. For better estimation the toxicity the dose volume histograms (DVH) were used. The volume of irradiated lung was an important factor for pneumonitis progress.ConclusionsDose volume histograms (DVH) with clinical evaluation can predict pulmonary toxicity (pneumonitis) and colud allow us to evaluate volume of irradiated lung with the highest acceptable dose

88. Comparison results of different strategies of radiotherapy in nasopharyngeal carcinoma

Aim: Evaluation results of radiotherapy in nasopharyngeal carcinoma in years; 1980–1990 (before CT era) vs 1991–1995.Material/methods: One hundred eighty eight patients treated in our centre were included in this analysis. Two groups of patients were distinguished: I-st – 128 patients (treated between 1980–1990) and II-nd – 60 (treated between 1991–1995). The possibilities of diagnosis and radiotherapy techniques were diffrent in both groups. In the II-nd group; the shrinking field technique, CT in diagnosis and target delineation and also higher total dose (mean 66 Gy) were applied.Results: For all patients 5-years disease free-survival was 30%. During follow-up the first two years were crucial, because 80% of failures occured. The causes of failures were as follow: the local recurrence (43%), metastases to lymph nodes (39%) and distant metastases (18%).Conclusions: Introducing CT into diagnosis and target delineation, the shrinking field technique and higher total dose of irradiation caused in improvement of results of radiotherapy in nasopharyngeal carcinoma

Metabolomic and high-throughput sequencing analysis—modern approach for the assessment of biodeterioration of materials from historic buildings

Preservation of cultural heritage is of paramount importance worldwide. Microbial colonization of construction materials, such as wood, brick, mortar and stone in historic buildings can lead to severe deterioration. The aim of the present study was to give modern insight into the phylogenetic diversity and activated metabolic pathways of microbial communities colonized historic objects located in the former Auschwitz II-Birkenau concentration and extermination camp in Oświęcim, Poland. For this purpose we combined molecular, microscopic and chemical methods. Selected specimens were examined using Field Emission Scanning Electron Microscopy (FESEM), metabolomic analysis and high-throughput Illumina sequencing. FESEM imaging revealed the presence of complex microbial communities comprising diatoms, fungi and bacteria, mainly cyanobacteria and actinobacteria, on sample surfaces. Microbial diversity of brick specimens appeared higher than that of the wood and was dominated by algae and cyanobacteria, while wood was mainly colonized by fungi. DNA sequences documented the presence of 15 bacterial phyla representing 99 genera including Halomonas, Halorhodospira, Salinisphaera, Salinibacterium, Rubrobacter, Streptomyces, Arthrobacter and 9 fungal classes represented by 113 genera including Cladosporium, Acremonium, Alternaria, Engyodontium, Penicillium, Rhizopus and Aureobasidium. Most of the identified sequences were characteristic of organisms implicated in deterioration of wood and brick. Metabolomic data indicated the activation of numerous metabolic pathways, including those regulating the production of primary and secondary metabolites, for example, metabolites associated with the production of antibiotics, organic acids and deterioration of organic compounds. The study demonstrated that a combination of electron microscopy imaging with metabolomic and genomic techniques allows to link the phylogenetic information and metabolic profiles of microbial communities and to shed new light on biodeterioration processes

HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy

<p>Abstract</p> <p>Background</p> <p>The response rate of ovarian mucinous carcinomas to paclitaxel/carboplatin is low, prompting interest in targeted molecular therapies. We investigated HER2 expression and amplification, and the potential for trastuzumab therapy in this histologic subtype of ovarian cancer.</p> <p>Methods</p> <p>HER2 status was tested in 33 mucinous carcinomas and 16 mucinous borderline ovarian tumors (BOT)). Five cases with documented recurrence and with tissue from the recurrence available for testing were analyzed to determine whether HER2 amplification status changed over time. Three prospectively identified recurrent mucinous ovarian carcinomas were assessed for HER2 amplification and patients received trastuzumab therapy with conventional chemotherapy.</p> <p>Results</p> <p>Amplification of HER2 was observed in 6/33 (18.2%) mucinous carcinomas and 3/16 (18.8%) BOT. HER2 amplification in primary mucinous carcinomas was not associated with an increased likelihood of recurrence. The prospectively identified recurrent mucinous carcinomas showed overexpression and amplification of HER2; one patient's tumor responded dramatically to trastuzumab in combination with conventional chemotherapy, while another patient experienced an isolated central nervous system recurrence after trastuzumab therapy.</p> <p>Conclusion</p> <p>HER2 amplification is relatively common in ovarian mucinous carcinomas (6/33, 18.2%), although not of prognostic significance. Trastuzumab therapy is a treatment option for patients with mucinous carcinoma when the tumor has HER2 amplification and overexpression.</p

Airbnb and crime in Barcelona (Spain): testing the relationship using a geographically weighted regression

The existence of works proving the possible relationship empirically that Airbnb lodgings could have with crime in Spain is not known. This research analyzes the relationship between Airbnb lodgings and crimes against the properties and people in Barcelona’s neighbourhoods. To achieve this, we use an ordinary least squares regression model and a geographically weighted regression model. The results show a significant and positive relationship between the higher density of Airbnb lodgings and the higher crime rates in the neighbourhoods, especially of patrimonial nature. Divided by type of leased space, the Airbnb homes, in which the guest shares a room with other guests, show a higher relationship with crimes against property and people. The results of the local model show a spatial heterogeneity in all variables used, indicating the need to address non-stationary spatial processes that reveal hidden patterns. However, the only variable that shows statistically significant local variability is the total Airbnb lodgings variable. Finally, we discussed some unexpected results, proposing some future lines of research. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Nanjing Normal University