Drastic Reductions in Mental Well-Being Observed Globally During the COVID-19 Pandemic: Results From the ASAP Survey

Most countries affected by the COVID-19 pandemic have repeatedly restricted public life to control the contagion. However, the health impact of confinement measures is hitherto unclear. We performed a multinational survey investigating changes in mental and physical well-being (MWB/PWB) during the first wave of the pandemic. A total of 14,975 individuals from 14 countries provided valid responses. Compared to pre-restrictions, MWB, as measured by the WHO-5 questionnaire, decreased considerably during restrictions (68.1 +/- 16.9 to 51.9 +/- 21.0 points). Whereas 14.2% of the participants met the cutoff for depression screening pre-restrictions, this share tripled to 45.2% during restrictions. Factors associated with clinically relevant decreases in MWB were female sex (odds ratio/OR = 1.20, 95% CI: 1.11-1.29), high physical activity levels pre-restrictions (OR = 1.29, 95% CI 1.16-1.42), decreased vigorous physical activity during restrictions (OR = 1.14, 95% CI: 1.05-1.23), and working (partially) outside the home vs. working remotely (OR = 1.29, 95% CI: 1.16-1.44/OR = 1.35, 95% CI: 1.23-1.47). Reductions, although smaller, were also seen for PWB. Scores in the SF-36 bodily pain subscale decreased from 85.8 +/- 18.7% pre-restrictions to 81.3 +/- 21.9% during restrictions. Clinically relevant decrements of PWB were associated with female sex (OR = 1.62, 95% CI: 1.50-1.75), high levels of public life restrictions (OR = 1.26, 95% CI: 1.18-1.36), and young age (OR = 1.10, 95% CI: 1.03-1.19). Study findings suggest lockdowns instituted during the COVID-19 pandemic may have had substantial adverse public health effects. The development of interventions mitigating losses in MWB and PWB is, thus, paramount when preparing for forthcoming waves of COVID-19 or future public life restrictions.DJ-P is supported by a grant from the Spanish Ministry of Science and Innovation-MINECO (RYC-2014-16938). The research fellowship of KH was funded by the German Research Foundation (Grant no. HO 6214/2-1)

Restrictercise! Preferences Regarding Digital Home Training Programs during Confinements Associated with the COVID-19 Pandemic

Confinement measures during the COVID-19 pandemic have caused substantial reductions in global physical activity (PA) levels. In view of the manifold health benefits of PA, the development of interventions counteracting this trend is paramount. Our survey with 15,261 participants (38 +/- 15 years, 58.5% females) examined preferences towards digital home exercise programs in 14 countries affected by COVID-19. More than two-thirds of the sample (68.4%, n = 10,433) indicated being interested in home exercise, and most participants were willing to work out at least three times per week (89.3%, n = 9328). Binary logistic regression revealed that female sex, working part-time, younger age, and being registered in a gym were associated with willingness to exercise. Flexibility (71.1%, n = 7377), resistance (68.6%, n = 7116), and endurance training (62.4%, n = 6478) were the most preferred types of exercise. Our results may guide health providers in developing individually tailored PA interventions during the current and future pandemic

A Pandemic within the Pandemic? Physical Activity Levels Substantially Decreased in Countries Affected by COVID-19

Governments have restricted public life during the COVID-19 pandemic, inter alia closing sports facilities and gyms. As regular exercise is essential for health, this study examined the effect of pandemic-related confinements on physical activity (PA) levels. A multinational survey was performed in 14 countries. Times spent in moderate-to-vigorous physical activity (MVPA) as well as in vigorous physical activity only (VPA) were assessed using the Nordic Physical Activity Questionnaire (short form). Data were obtained for leisure and occupational PA pre- and during restrictions. Compliance with PA guidelines was calculated based on the recommendations of the World Health Organization (WHO). In total, n = 13,503 respondents (39 +/- 15 years, 59% females) were surveyed. Compared to pre-restrictions, overall self-reported PA declined by 41% (MVPA) and 42.2% (VPA). Reductions were higher for occupational vs. leisure time, young and old vs. middle-aged persons, previously more active vs. less active individuals, but similar between men and women. Compared to pre-pandemic, compliance with WHO guidelines decreased from 80.9% (95% CI: 80.3-81.7) to 62.5% (95% CI: 61.6-63.3). Results suggest PA levels have substantially decreased globally during the COVID-19 pandemic. Key stakeholders should consider strategies to mitigate loss in PA in order to preserve health during the pandemic

Anomalous Hypothalamic Responses to Humor in Cataplexy

Cataplexy is observed in a subset of patients with narcolepsy and affects approximately 1 in 2,000 persons. Cataplexy is most often triggered by strong emotions such as laughter, which can result in transient, yet debilitating, muscle atonia. The objective of this study was to examine the neural systems underlying humor processing in individuals with cataplexy.While undergoing functional Magnetic Resonance Imaging (fMRI), we showed ten narcolepsy-cataplexy patients and ten healthy controls humorous cartoons. In addition, we examined the brain activity of one subject while in a full-blown cataplectic attack. Behavioral results showed that participants with cataplexy rated significantly fewer humorous cartoons as funny compared to controls. Concurrent fMRI showed that patients, when compared to controls and in the absence of overt cataplexy symptoms, showed pronounced activity in the emotional network including the ventral striatum and hypothalamus while viewing humorous versus non-humorous cartoons. Increased activity was also observed in the right inferior frontal gyri--a core component of the inhibitory circuitry. In comparison, the one subject who experienced a cataplectic attack showed dramatic reductions in hypothalamic activity.These findings suggest an overdrive of the emotional circuitry and possible compensatory suppression by cortical inhibitory regions in cataplexy. Moreover, during cataplectic attacks, the hypothalamus is characterized by a marked decrease in activity similar to that observed during sleep. One possible explanation for these findings is an initial overdrive and compensatory shutdown of the hypothalamus resulting in full cataplectic symptoms

Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Importance Coronavirus disease 2019 (COVID-19) affects the nervous system in adult patients. The spectrum of neurologic involvement in children and adolescents is unclear. Objective To understand the range and severity of neurologic involvement among children and adolescents associated with COVID-19. Setting, Design, and Participants Case series of patients (age <21 years) hospitalized between March 15, 2020, and December 15, 2020, with positive severe acute respiratory syndrome coronavirus 2 test result (reverse transcriptase-polymerase chain reaction and/or antibody) at 61 US hospitals in the Overcoming COVID-19 public health registry, including 616 (36%) meeting criteria for multisystem inflammatory syndrome in children. Patients with neurologic involvement had acute neurologic signs, symptoms, or diseases on presentation or during hospitalization. Life-threatening involvement was adjudicated by experts based on clinical and/or neuroradiologic features. Exposures Severe acute respiratory syndrome coronavirus 2. Main Outcomes and Measures Type and severity of neurologic involvement, laboratory and imaging data, and outcomes (death or survival with new neurologic deficits) at hospital discharge. Results Of 1695 patients (909 [54%] male; median [interquartile range] age, 9.1 [2.4-15.3] years), 365 (22%) from 52 sites had documented neurologic involvement. Patients with neurologic involvement were more likely to have underlying neurologic disorders (81 of 365 [22%]) compared with those without (113 of 1330 [8%]), but a similar number were previously healthy (195 [53%] vs 723 [54%]) and met criteria for multisystem inflammatory syndrome in children (126 [35%] vs 490 [37%]). Among those with neurologic involvement, 322 (88%) had transient symptoms and survived, and 43 (12%) developed life-threatening conditions clinically adjudicated to be associated with COVID-19, including severe encephalopathy (n = 15; 5 with splenial lesions), stroke (n = 12), central nervous system infection/demyelination (n = 8), Guillain-Barré syndrome/variants (n = 4), and acute fulminant cerebral edema (n = 4). Compared with those without life-threatening conditions (n = 322), those with life-threatening neurologic conditions had higher neutrophil-to-lymphocyte ratios (median, 12.2 vs 4.4) and higher reported frequency of D-dimer greater than 3 μg/mL fibrinogen equivalent units (21 [49%] vs 72 [22%]). Of 43 patients who developed COVID-19–related life-threatening neurologic involvement, 17 survivors (40%) had new neurologic deficits at hospital discharge, and 11 patients (26%) died. Conclusions and Relevance In this study, many children and adolescents hospitalized for COVID-19 or multisystem inflammatory syndrome in children had neurologic involvement, mostly transient symptoms. A range of life-threatening and fatal neurologic conditions associated with COVID-19 infrequently occurred. Effects on long-term neurodevelopmental outcomes are unknown

The Relationship Between Vertical Loadrates and Tibial Acceleration Across Footstrike Patterns

Category: Other Introduction/Purpose: While the etiology of injuries is multifactorial, impact loading, as measured by the loadrate of the vertical ground reaction force has been implicated. These loadrates are typically measured with a force plate. However, this limits the measure of impacts to laboratory environments. Tibial acceleration, another measure of running impacts, is considered a surrogate for loadrate. It can be measured using new wearable technology that can be used in a runner’s natural environment. However, the correlation between tibial acceleration measured from mobile devices and vertical ground reaction force loadrates, measured from forceplates, is unknown. The purpose of this study was to determine the correlation between vertical and resultant loadrates to vertical and resultant tibial acceleration across different footstrike patterns (FSP) in runners. Methods: The study involved a sample of convenience made up of 169 runners (74 F, 95 M; age: 38.66±13.08 yrs) presenting at a running injury clinic. This included 25 habitual forefoot strike (FFS), 17 midfoot strike (MFS) and 127 rearfoot strike (RFS) runners. Participants ran on an instrumented treadmill (average speed 2.52±0.25 m/s), with a tri-axial accelerometer attached at the left distal medial tibia. Only subjects running with pain <3/10 on a VAS scale during the treadmill run were included to reduce the confounding effect of pain. Vertical average, vertical instantaneous and resultant instantaneous loadrates (VALR, VILR and RILR) and peak vertical and resultant tibial accelerations (VTA, RTA) were averaged for 8 consecutive left steps. Correlation coefficients (r) were calculated between tibial accelerations and loadrates. Results: All tibial accelerations were significantly correlated across all loadrates, with the exception of RTA with VILR for FFS (Table 1) which was nearly significant (p=0.068). Correlations ranged from 0.37-0.82. VTA was strongly correlated with all loadrates (r = 0.66). RTA was also strongly correlated with both loadrates for RFS and MFS, but only moderately correlated with loadrates for FFS (r = 0.47). Correlations were similar across the different loadrates (VALR, VILR, RILR). Conclusion: The stronger correlation between vertical tibial acceleration and all loadrates (VALR, VILR, RILR) suggests that it may be the best surrogate for loadrates when studying impact loading in runners

Mechanical Risk Factors for Stress Fracture in Elite Runners

Objectives: Bone stress injuries (BSI) are responsible for significant missed competition and training in distance runners. A recent review of our institution’s injury database revealed that one-fifth of NCAA-level runners sustained one or more BSI over a three-year period. While much is known about certain risk factors for stress injury such as the Female Athlete Triad, little is known about biomechanical risk factors including dynamic loading of the foot during running differs between athletes with history of BSI and those without. The aims of this study were: 1) characterize the dynamic loading patterns of elite distance runners during athletic movement, 2) determine the difference in dynamic loading magnitude and location in runners who have history of a BSI compared to non-injured runners and 3) establish a database to be used for follow-up evaluation. We hypothesized that athletes with a history of BSI in the lower extremity apply greater dynamic loads during athletic movements compared to uninjured athletes. Methods: We recruited 40 healthy varsity distance runners (16 females, 24 males) from our institution to participate in the study. Dynamic foot loading data was collected on all athletes using a validated wireless insole pressure measurement system during a series of athletic movements (e.g., walking, running and lateral cutting). Data was collected for contact area, maximum force, peak pressure, maximum mean pressure and force-time integral at each of eleven foot regions during each athletic movement. All force and pressure data were normalized to body weight. Injury history and other potential risk factors of interest were collected by self-report questionnaire and chart review. All BSI occurred as a result of participation of running, diagnosed by a physician and confirmed with advanced imaging. Mean values were calculated for each variable and foot region in each athlete and paired t-tests were performed for injury history comparisons. Results: A total of 23 runners with a history of 1 or more lower extremity BSI (11 females, 12 males), and 17 athletes with no history of BSI (5 females, 12 males) participated. Runners with a history of BSI trended toward greater peak pressures during running activities (p = .13) compared to uninjured controls, and displayed significantly greater peak pressures in the forefoot during cutting movements (p < .05). Further, those with history of BSI in the foot and ankle displayed greater force-time integral in the forefoot during running (p = .06). In the medial forefoot, athletes with history of BSI displayed significantly greater maximum mean pressures during jump takeoff (p < .05), running (p = .05) and cutting (p < .05). We did not observe a difference in foot strike patterns or FAAM Sport scores between injured and uninjured runners. Menstrual irregularities were seen in a majority of female athletes and were not associated with BSI. Conclusion: Our findings suggest that elite runners with a history of BSI exert greater pressures and force-time integral in the forefoot and medial midfoot during running and cutting compared to uninjured athletes. The greater loads in the forefoot and medial midfoot may play a role in the incidence and recurrence of BSI in running athletes. Further study of our athlete cohort will allow elucidation of specific high pressure points in the foot that may place athletes at risk for specific BSI, and allow us to investigate the utility of preventive measures

Outcomes Using Focused Shockwave for Treatment of Bone Stress Injury in Runners

Bone stress injury (BSI) is a common overuse injury that can result in prolonged time away from sport. Limited studies have characterized the use of extracorporeal shockwave therapy (ESWT) for the treatment of BSI. The purpose of this study was to describe the use of ESWT for the management of BSI in runners. A retrospective chart review was performed to identify eligible patients in a single physician’s clinic from 1 August 2018 to 30 September 2022. BSI was identified in 40 runners with 41 injuries (28 females; average age and standard deviation: 30 ± 13 years; average pre-injury training 72 ± 40 km per week). Overall, 63% (n = 26) met the criteria for moderate- or high-risk Female or Male Athlete Triad categories. Runners started ESWT at a median of 36 days (IQR 11 to 95 days; range 3 days to 8 years) from BSI diagnosis. On average, each received 5 ± 2 total focused ESWT treatments. Those with acute BSI (ESWT started 3 months, n = 3) or non-union (>6 months, n = 9) had longer time for return to running (19.8 ± 14.8 weeks, p = 0.032). All runners returned to pain-free running after ESWT except one runner with non-union of grade 4 navicular BSI who opted for surgery. No complications were observed with ESWT. These findings suggest that focused ESWT may be a safe treatment for the management of BSI in runners

Energy availability in athletics:Health, performance and physique

The reported prevalence of low energy availability (LEA) in female and male track and field athletes is between 18% and 58% with the highest prevalence among athletes in endurance and jump events. In male athletes, LEA may result in reduced testosterone levels and libido along with impaired training capacity. In female track and field athletes, functional hypothalamic amenorrhea as consequence of LEA has been reported among 60% of elite middle- and long-distance athletes and 23% among elite sprinters. Health concerns with functional hypothalamic amenorrhea include impaired bone health, elevated risk for bone stress injury, and cardiovascular disease. Furthermore, LEA negatively affects recovery, muscle mass, neuromuscular function, and increases the risk of injuries and illness that may affect performance negatively. LEA in track and field athletes may occur due to intentional alterations in body mass or body composition, appetite changes, time constraints, or disordered eating behavior. Long-term LEA causes metabolic and physiological adaptations to prevent further weight loss, and athletes may therefore be weight stable yet have impaired physiological function secondary to LEA. Achieving or maintaining a lower body mass or fat levels through long-term LEA may therefore result in impaired health and performance as proposed in the Relative Energy Deficiency in Sport model. Preventive educational programs and screening to identify athletes with LEA are important for early intervention to prevent long-term secondary health consequences. Treatment for athletes is primarily to increase energy availability and often requires a team approach including a sport physician, sports dietitian, physiologist, and psychologist