Changing children’s intergroup attitudes towards refugees: Testing different models of extended contact

The present research evaluated an intervention, derived from the "extended contact hypothesis," which aimed to change children's intergroup attitudes toward refugees. The study (n=253) tested 3 models of extended contact among 5- to 11-year-old children: dual identity, common ingroup identity, and decategorization. Children read friendship stories based upon these models featuring in- and outgroup members. Outgroup attitudes were significantly more positive in the extended contact conditions, compared with the control, and this was mediated by "inclusion of other in self." The dual identity intervention was the most effective extended contact model at improving outgroup attitudes. The effect of condition on outgroup intended behavior was moderated by subgroup identity. Implications for theoretically based prejudice-reduction interventions among children are discussed

Identities in transition: a longitudinal study of immigrant children

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Retinal Architecture in ​\u3cem\u3eRGS9-\u3c/em\u3e and ​\u3cem\u3eR9AP\u3c/em\u3e-Associated Retinal Dysfunction (Bradyopsia)

Purpose To characterize photoreceptor structure and mosaic integrity in subjects with RGS9- and R9AP-associated retinal dysfunction (bradyopsia) and compare to previous observations in other cone dysfunction disorders such as oligocone trichromacy. Design Observational case series. Methods setting: Moorfields Eye Hospital (United Kingdom) and Medical College Wisconsin (USA). study population: Six eyes of 3 subjects with disease-causing variants in RGS9 or R9AP. main outcome measures: Detailed retinal imaging using spectral-domain optical coherence tomography and confocal adaptive-optics scanning light ophthalmoscopy. Results Cone density at 100 μm from foveal center ranged from 123 132 cones/mm2to 140 013 cones/mm2. Cone density ranged from 30 573 to 34 876 cones/mm2 by 600 μm from center and from 15 987 to 16,253 cones/mm2 by 1400 μm from center, in keeping with data from normal subjects. Adaptive-optics imaging identified a small, focal hyporeflective lesion at the foveal center in both eyes of the subject with RGS9-associated disease, corresponding to a discrete outer retinal defect also observed on spectral-domain optical coherence tomography; however, the photoreceptor mosaic remained intact at all other observed eccentricities. Conclusions Bradyopsia and oligocone trichromacy share common clinical symptoms and cannot be discerned on standard clinical findings alone. Adaptive-optics imaging previously demonstrated a sparse mosaic of normal wave-guiding cones remaining at the fovea, with no visible structure outside the central fovea in oligocone trichromacy. In contrast, the subjects presented in this study with molecularly confirmed bradyopsia had a relatively intact and structurally normal photoreceptor mosaic, allowing the distinction between these disorders based on the cellular phenotype and suggesting different pathomechanisms

Epistemic value in the subpersonal vale

A vexing problem in contemporary epistemology – one with origins in Plato’s Meno – concerns the value of knowledge, and in particular, whether and how the value of knowledge exceeds the value of mere (unknown) true opinion. The recent literature is deeply divided on the matter of how best to address the problem. One point, however, remains unquestioned: that if a solution is to be found, it will be at the personal level, the level at which states of subjects or agents, as such, appear. We take exception to this orthodoxy, or at least to its unquestioned status. We argue that subpersonal states play a significant – arguably, primary – role in much epistemically relevant cognition and thus constitute a domain in which we might reasonably expect to locate the “missing source” of epistemic value, beyond the value attached to mere true belief

Local terrestrial biodiversity impacts in life cycle assessment:A case study of sedum roofs in London, UK

Urban development is a key driver of global biodiversity loss. “Green” infrastructure is integrated to offset some impacts of development on ecosystem quality by supporting urban biodiversity, a prominent example being green roofs. The effects of green infrastructures on urban biodiversity are not well understood and poorly included in life cycle assessment (LCA) methodology. Here, we present a novel methodology that quantifies the local impact of green infrastructures on terrestrial biodiversity—demonstrated here for sedum roofs in London, UK—and integrates within LCA. It relates energy provision by plants to the metabolic requirements of animals to determine what species richness (number of species) and species abundance (number of individuals) are supported. We demonstrate this methodology using a case study, comparing the life cycle impact of developing 18 buildings, with either asphalt concrete or sedum roofs, on ecosystem quality. We found the sedum roofs (0.018 km 2) support 53 species (673 individuals), equivalent to 1.3% of the development's life cycle impacts on ecosystem quality. Complete offsetting requires considerable reduction in transport use throughout the development's lifetime, and lower environmental impact material selection during construction (contributing 98% and 2%, respectively). The results indicate sedum roofs offer minor impact mitigation capacities in the context of urban development, and this capacity is limited for all green infrastructures by species richness in local species pools. This paper demonstrates the potential and limitations of quantifying terrestrial biodiversity offsets offered by green infrastructures alongside urbanization, and the need for realistic expectations of what role it might play in sustainable urban design.</p

Local Terrestrial Biodiversity Impacts in Life Cycle Assessment: A Case Study of Sedum Roofs in London, UK

Urban development is a key driver of global biodiversity loss. ‘Green infrastructure is integrated to offset some impacts of development on ecosystem quality by supporting urban biodiversity. A prominent example being green roofs. The effects of green infrastructures on urban biodiversity are not well understood and poorly included in life cycle assessment (LCA) methodology. Here, we present a novel methodology that quantifies the local impact of green infrastructures on terrestrial biodiversity – demonstrated here for sedum roofs in London, UKand integrates within LCA. It relates energy provision by plants to the metabolic requirements of animals, to determine what species richness (number of species) and species abundance (number of individuals) are supported. We demonstrate this methodology using a case study, comparing the life cycle impact of developing 18 buildings, with either asphalt concrete or sedum roofs, on ecosystem quality. We found the sedum roofs (0.018 km2) support 53 species(673 individuals), equivalent to 1.3% of the development’s life cycle impacts on ecosystem quality. Complete offsetting requires considerable reduction in transport use throughout the development’s lifetime, and lower environmental impact material selection during construction (contributing 98% and 2% respectively). The results indicate sedum roofs offer minor impact mitigation capacities in the context of urban development, and this capacity is limited for allgreen infrastructures by species richness in local species pools. This paper demonstrates the potential and limitations of quantifying terrestrial biodiversity offsets offered by green infrastructures alongside urbanisation, and the need for realistic expectations of what role it might play in sustainable urban design.<br/

Boosting Line Intensity Map Signal-to-Noise with the Ly-α\alpha Forest Cross-Correlation

We forecast the prospects for cross-correlating future line intensity mapping (LIM) surveys with the current and future Ly-$\alpha$ forest data. We use large cosmological hydrodynamic simulations to model the expected emission signal for the CO rotational transition in the COMAP LIM experiment at the 5-year benchmark and the Ly-$\alpha$ forest absorption signal for various surveys, including eBOSS, DESI, and PFS. We show that CO$\times$Ly-$\alpha$ forest can significantly enhance the detection signal-to-noise ratio of CO, with a $200$ to $300 \%$ improvement when cross-correlated with the forest observed in the Prime Focus Spectrograph (PFS) survey and a $50$ to $75\%$ enhancement for the currently available eBOSS or the upcoming DESI observations. We compare to the signal-to-noise improvements expected for a galaxy survey and show that CO$\times$Ly-$\alpha$ is competitive with even a spectroscopic galaxy survey in raw signal-to-noise. Furthermore, our study suggests that the clustering of CO emission is tightly constrained by CO$\times$Ly-$\alpha$ forest, due to the increased signal-to-noise ratio and the simplicity of Ly-$\alpha$ absorption power spectrum modeling. Any foreground contamination or systematics are expected not to be shared between LIM surveys and Ly-$\alpha$ forest observations; this provides an unbiased inference. Our findings highlight the potential benefits of utilizing the Ly-$\alpha$ forest to aid in the initial detection of signals in line intensity experiments. For example, we also estimate that [CII]$\times$Ly-$\alpha$ forest measurements from EXCLAIM and DESI/eBOSS, respectively, should have a larger signal-to-noise ratio than planned [CII]$\times$quasar observations by about an order of magnitude. Our results can be readily applied to actual data thanks to the observed quasar spectra in eBOSS Stripe 82, which overlaps with several LIM surveys.Comment: Codes and the produced data are available at https://github.com/qezlou/lal

Does Modality of Survey Administration Impact Data Quality: Audio Computer Assisted Self Interview (ACASI) Versus Self-Administered Pen and Paper?

BACKGROUND. In the context of a randomized controlled trial (RCT) on HIV testing in the emergency department (ED) setting, we evaluated preferences for survey modality and data quality arising from each modality. METHODS. Enrolled participants were offered the choice of answering a survey via audio computer assisted self-interview (ACASI) or pen and paper self-administered questionnaire (SAQ). We evaluated factors influencing choice of survey modality. We defined unusable data for a particular survey domain as answering fewer than 75% of the questions in the domain. We then compared ACASI and SAQ with respect to unusable data for domains that address sensitive topics. RESULTS. Of 758 enrolled ED patients, 218 (29%) chose ACASI, 343 chose SAQ (45%) and 197 (26%) opted not to complete either. Results of the log-binomial regression indicated that older (RR=1.08 per decade) and less educated participants (RR=1.25) were more likely to choose SAQ over ACASI. ACASI yielded substantially less unusable data than SAQ. CONCLUSIONS. In the ED setting there may be a tradeoff between increased participation with SAQ versus better data quality with ACASI. Future studies of novel approaches to maximize the use of ACASI in the ED setting are needed.National Institute of Mental Health (R01 MH073445, R01 MH65869

Prolactin stimulates precursor cells in the adult mouse hippocampus

In the search for ways to combat degenerative neurological disorders, neurogenesis-stimulating factors are proving to be a promising area of research. In this study, we show that the hormonal factor prolactin (PRL) can activate a pool of latent precursor cells in the adult mouse hippocampus. Using an in vitro neurosphere assay, we found that the addition of exogenous PRL to primary adult hippocampal cells resulted in an approximate 50% increase in neurosphere number. In addition, direct infusion of PRL into the adult dentate gyrus also resulted in a significant increase in neurosphere number. Together these data indicate that exogenous PRL can increase hippocampal precursor numbers both in vitro and in vivo. Conversely, PRL null mice showed a significant reduction (approximately 80%) in the number of hippocampal-derived neurospheres. Interestingly, no deficit in precursor proliferation was observed in vivo, indicating that in this situation other niche factors can compensate for a loss in PRL. The PRL loss resulted in learning and memory deficits in the PRL null mice, as indicated by significant deficits in the standard behavioral tests requiring input from the hippocampus. This behavioral deficit was rescued by direct infusion of recombinant PRL into the hippocampus, indicating that a lack of PRL in the adult mouse hippocampus can be correlated with impaired learning and memory