Adhesive Rough Surface Contact

The focus of this dissertation is to use analytical and numerical methods to determine mechanisms which increase or decrease the adherence force between micro-scale components. Several different methods are used to accomplish this task: 1) a traditional statistical approach is used to analytically determine the adherence force as a function of surface roughness; 2) a semi-analytical solution is developed for the adhesion of isotropic rough surfaces; 3) a numerical approach utilizes a three-dimensional surface characterization to determine adherence force trends with respect to roughness and material parameters; 4) combining a micro-scaled friction model with item 3), static friction forces are determined as a function of material parameters as well as surface roughness. To inspire further rough surface solutions, an adhesive solution for cylinders is extended to include the solution regime for when there is no longer intimate contact, but adhesive forces are still active. For each of these methodologies there are advantages and disadvantages which arise from the assumptions made in constructing the solution, which are subsequently discussed

Understanding young people's transitions in university halls through space and time

This article contributes to the theoretical discussion about young people's transitions through space and time. Space and time are complex overarching concepts that have creative potential in deepening understanding of transition. The focus of this research is young people's experiences of communal living in university halls. It is argued that particular space-time concepts draw attention to different facets of experience and in combination deepen the understanding of young people's individual and collective transitions. The focus of the article is the uses of the space-time concepts 'routine', 'representation', 'rhythm' and 'ritual' to research young people's experiences. The article draws on research findings from two studies in the North of England. © 2010 SAGE Publications

Writing to Save the Earth

A Magazine of Sustainable Ideas from EN199 Writing for the Earth (Professor John Kucich, Fall 2015) A Sense of Place: Essays on Where We Live Fogo, Cabo Verde, by Leonarda Vieira Weweantic River, by Sydney Holbrook Carver Pond, by Brianna Gallagher Nantasket Beach, by Brianna Davidson Ames Nowell, by Cassidy Morrow Old Orchard Beach, by Jill Blye A Place in the Sky, by Danielle Souza Pond Meadow, by Samantha Cicirelli Imagining a Future: Speculative Fiction Peggy the Penguin in Antarctica, by Haley Piotrowski Lives Change in One Day, by Julianne Kilduff Dust, by Adam Hayes Taking Action: Policy, Politics and Activisim Climate Reality, by Brea Caisey Wind Turbines in Massachusetts, by William Tkaczu

Spin-orbit coupling control of anisotropy, ground state and frustration in 5d2 Sr2MgOsO6

The influence of spin-orbit coupling (SOC) on the physical properties of the 5d2 system Sr2MgOsO6 is probed via a combination of magnetometry, specific heat measurements, elastic and inelastic neutron scattering, and density functional theory calculations. Although a significant degree of frustration is expected, we find that Sr2MgOsO6 orders in a type I antiferromagnetic structure at the remarkably high temperature of 108 K. The measurements presented allow for the first accurate quantification of the size of the magnetic moment in a 5d2 system of 0.60(2) μB –a significantly reduced moment from the expected value for such a system. Furthermore, significant anisotropy is identified via a spin excitation gap, and we confirm by first principles calculations that SOC not only provides the magnetocrystalline anisotropy, but also plays a crucial role in determining both the ground state magnetic order and the size of the local moment in this compound. Through comparison to Sr2ScOsO6, it is demonstrated that SOC-induced anisotropy has the ability to relieve frustration in 5d2 systems relative to their 5d3 counterparts, providing an explanation of the high TN found in Sr2MgOsO6

From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking

Small-molecule stabilization of protein-protein interactions (PPIs) is a promising strategy in chemical biology and drug discovery. However, the systematic discovery of PPI stabilizers remains a largely unmet challenge. Herein we report a fragment-linking approach targeting the interface of 14-3-3 and a peptide derived from the estrogen receptor alpha (ERα) protein. Two classes of fragments—a covalent and a noncovalent fragment—were co-crystallized and subsequently linked, resulting in a noncovalent hybrid molecule in which the original fragment interactions were largely conserved. Supported by 20 crystal structures, this initial hybrid molecule was further optimized, resulting in selective, 25-fold stabilization of the 14-3-3/ERα interaction. The high-resolution structures of both the single fragments, their co-crystal structures and those of the linked fragments document a feasible strategy to develop orthosteric PPI stabilizers by linking to an initial tethered fragment.</p