1,527 research outputs found
A model for gelation with explicit solvent effects: Structure and dynamics
We study a two-component model for gelation consisting of -functional
monomers (the gel) and inert particles (the solvent). After equilibration as a
simple liquid, the gel particles are gradually crosslinked to each other until
the desired number of crosslinks has been attained. At a critical crosslink
density the largest gel cluster percolates and an amorphous solid forms. This
percolation process is different from ordinary lattice or continuum percolation
of a single species in the sense that the critical exponents are new. As the
crosslink density approaches its critical value , the shear viscosity
diverges: with a nonuniversal
concentration-dependent exponent.Comment: 6 pages, 9 figure
Wave propagation in axion electrodynamics
In this paper, the axion contribution to the electromagnetic wave propagation
is studied. First we show how the axion electrodynamics model can be embedded
into a premetric formalism of Maxwell electrodynamics. In this formalism, the
axion field is not an arbitrary added Chern-Simon term of the Lagrangian, but
emerges in a natural way as an irreducible part of a general constitutive
tensor.We show that in order to represent the axion contribution to the wave
propagation it is necessary to go beyond the geometric approximation, which is
usually used in the premetric formalism. We derive a covariant dispersion
relation for the axion modified electrodynamics. The wave propagation in this
model is studied for an axion field with timelike, spacelike and null
derivative covectors. The birefringence effect emerges in all these classes as
a signal of Lorentz violation. This effect is however completely different from
the ordinary birefringence appearing in classical optics and in premetric
electrodynamics. The axion field does not simple double the ordinary light cone
structure. In fact, it modifies the global topological structure of light cones
surfaces. In CFJ-electrodynamics, such a modification results in violation of
causality. In addition, the optical metrics in axion electrodynamics are not
pseudo-Riemannian. In fact, for all types of the axion field, they are even
non-Finslerian
QCD Corrections and the Endpoint of the Lepton Spectrum in Semileptonic B Decays
Recently, Neubert has suggested that a certain class of nonperturbative
corrections dominates the shape of the electron spectrum in the endpoint region
of semileptonic decay. Perturbative QCD corrections are important in the
endpoint region. We study the effects of these corrections on Neubert's
proposal. The connection between the endpoint of the electron spectrum in
semileptonic decay and the photon spectrum in is
outlined.Comment: 18 pages, uses REVTeX, UCSD/PTH 93-38, CALT-68-1910, JHU-TIPAC-930029
(some changes to the discussion of subleading radiative corrections, and
minor typos fixed
Adolescent trajectories of aerobic fitness and adiposity as markers of cardiometabolic risk in adulthood
Purpose: The aim of this study was to investigate whether adolescent growth trajectories of aerobic fitness and adiposity were associated with mid-adulthood cardiometabolic risk (CMR). Methods: Participants were drawn from the Saskatchewan Growth and Development Study (1963-1973). Adolescent growth trajectories for maximal aerobic capacity (absolute VO2 (AbsVO2)), skinfolds (SF), representing total body (Sum6SF) and central adiposity (TrunkSF), and body mass index (BMI) were determined from 7 to 17 years of age. In mid-adulthood (40 to 50 years of age), 61 individuals (23 females) returned for follow-ups. A CMR score was calculated to group participants as displaying either high or a low CMR. Multilevel hierarchical models were constructed, comparing the adolescent growth trajectories of AbsVO2, Sum6SF, TrunkSF, and BMI between CMR groupings. Results: There were no significant differences in the adolescent development of AbsVO2, Sum6SF, TrunkSF, and BMI between adult CMR groupings (p > 0.05). Individuals with high CMR accrued 62% greater adjusted total body fat percentage from adolescence to adulthood (p=0.03). Conclusions: Growth trajectories of adolescent aerobic fitness and adiposity do not appear to be associated with mid-adulthood CMR. Individuals should be encouraged to participate in behaviours that promote healthy aerobic fitness and adiposity levels throughout life to reduce lifelong CMR
Orbital and spin contributions to the -tensors in metal nanoparticles
We present a theoretical study of the mesoscopic fluctuations of -tensors
in a metal nanoparticle. The calculations were performed using a semi-realistic
tight-binding model, which contains both spin and orbital contributions to the
-tensors. The results depend on the product of the spin-orbit scattering
time and the mean-level spacing , but are
otherwise weakly affected by the specific shape of a {\it generic}
nanoparticle. We find that the spin contribution to the -tensors agrees with
Random Matrix Theory (RMT) predictions. On the other hand, in the strong
spin-orbit coupling limit , the
orbital contribution depends crucially on the space character of the
quasi-particle wavefunctions: it levels off at a small value for states of
character but is strongly enhanced for states of character. Our numerical
results demonstrate that when orbital coupling to the field is included, RMT
predictions overestimate the typical -factor of orbitals that have dominant
-character. This finding points to a possible source of the puzzling
discrepancy between theory and experiment.Comment: 21 pages, 6 figures; accepted for publication in Physical Review
Bounds from Primordial Black Holes with a Near Critical Collapse Initial Mass Function
Recent numerical evidence suggests that a mass spectrum of primordial black
holes (PBHs) is produced as a consequence of near critical gravitational
collapse. Assuming that these holes formed from the initial density
perturbations seeded by inflation, we calculate model independent upper bounds
on the mass variance at the reheating temperature by requiring the mass density
not exceed the critical density and the photon emission not exceed current
diffuse gamma-ray measurements. We then translate these results into bounds on
the spectral index n by utilizing the COBE data to normalize the mass variance
at large scales, assuming a constant power law, then scaling this result to the
reheating temperature. We find that our bounds on n differ substantially
(\delta n > 0.05) from those calculated using initial mass functions derived
under the assumption that the black hole mass is proportional to the horizon
mass at the collapse epoch. We also find a change in the shape of the diffuse
gamma-ray spectrum which results from the Hawking radiation. Finally, we study
the impact of a nonzero cosmological constant and find that the bounds on n are
strengthened considerably if the universe is indeed vacuum-energy dominated
today.Comment: 24 pages, REVTeX, 5 figures; minor typos fixed, two refs added,
version to be published in PR
Excited Heavy Mesons Beyond Leading Order in the Heavy Quark Expansion
We examine the decays of excited heavy mesons, including the leading power
corrections to the heavy quark limit. We find a new and natural explanation for
the large deviation of the width of the from the heavy quark
symmetry prediction. Our formalism leads to detailed predictions for the
properties of the excited bottom mesons, some of which recently have been
observed. Finally, we present a detailed analysis of the effect of power
corrections and finite meson widths on the angular distributions which may be
measured in heavy meson decays.Comment: Uses REVTeX, 19 pages, 6 EPS figures embedded with epsf.st
Assessment of the cortisol awakening response: expert consensus guidelines
The cortisol awakening response (CAR), the marked increase in cortisol secretion over the first 30–45 min after morning awakening, has been related to a wide range of psychosocial, physical and mental health parameters, making it a key variable for psychoneuroendocrinological research. The CAR is typically assessed from self-collection of saliva samples within the domestic setting. While this confers ecological validity, it lacks direct researcher oversight which can be problematic as the validity of CAR measurement critically relies on participants closely following a timed sampling schedule, beginning with the moment of awakening. Researchers assessing the CAR thus need to take important steps to maximize and monitor saliva sampling accuracy as well as consider a range of other relevant methodological factors. To promote best practice of future research in this field, the International Society of Psychoneuroendocrinology initiated an expert panel charged with (i) summarizing relevant evidence and collective experience on methodological factors affecting CAR assessment and (ii) formulating clear consensus guidelines for future research. The present report summarizes the results of this undertaking. Consensus guidelines are presented on central aspects of CAR assessment, including objective control of sampling accuracy/adherence, participant instructions, covariate accounting, sampling protocols, quantification strategies as well as reporting and interpreting of CAR data. Meeting these methodological standards in future research will create more powerful research designs, thus yielding more reliable and reproducible results and helping to further advance understanding in this evolving field of research
Gain-of-Function Mutation in Filamin A Potentiates Platelet Integrin αβ Activation
OBJECTIVE: Dominant mutations of the X-linked filamin A () gene are responsible for filaminopathies A, which are rare disorders including brain periventricular nodular heterotopia, congenital intestinal pseudo-obstruction, cardiac valves or skeleton malformations, and often macrothrombocytopenia.
APPROACH AND RESULTS: We studied a male patient with periventricular nodular heterotopia and congenital intestinal pseudo-obstruction, his unique X-linked allele carrying a stop codon mutation resulting in a 100-amino acid-long FLNa C-terminal extension (NP_001447.2: ). Platelet counts were normal, with few enlarged platelets. FLNa was detectable in all platelets but at 30% of control levels. Surprisingly, all platelet functions were significantly upregulated, including platelet aggregation and secretion, as induced by ADP, collagen, or von Willebrand factor in the presence of ristocetin, as well as thrombus formation in blood flow on a collagen or on a von Willebrand factor matrix. Most importantly, patient platelets stimulated with ADP exhibited a marked increase in αβ integrin activation and a parallel increase in talin recruitment to β, contrasting with normal Rap1 activation. These results are consistent with the mutant FLNa affecting the last step of αβ activation. Overexpression of mutant FLNa in the HEL megakaryocytic cell line correlated with an increase (compared with wild-type FLNa) in PMA-induced fibrinogen binding to and in talin and kindlin-3 recruitment by αβ.
CONCLUSIONS: Altogether, our results are consistent with a less binding of mutant FLNa to β and the facilitated recruitment of talin by β on platelet stimulation, explaining the increased αβ activation and the ensuing gain-of-platelet functions
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