Moving Forward by Looking Back: How Family Firms Create Competitive Advantage by Embracing Their History

Family businesses are the engine that drives the United States economy. While extensive implications have been made in the literature about the advantages or disadvantages of family-owned businesses compared to non-family-owned businesses, the focus of this study was to show how small to medium-sized family-owned firms (FF SMEs) based in the United States can use their unique history to create a competitive advantage. Drawing on imprint theory and the resource-based view (RBV), this history-informed study helped identify the impact that founder imprints, business traditions, and storytelling have on the business performance of FF SMEs. Using quantitative methods, the findings of this study show that as FF SMEs place an increased focus on their business traditions and build their competency for storytelling, they create a competitive advantage and positively impact their performance. Additionally, a moderating effect was found between the variables of business traditions and storytelling and the variables of founder imprints and business performance, which demonstrates that the moderating effect can be controlled by leadership, can influence business performance, and can reduce the impact of founder imprints. Therefore, the findings of this study extend the literature on founder imprints and rhetorical history and provide a roadmap for how FF SME owners can curate traditions and develop a competency for storytelling competency among its leaders

The Design and Implementation of Database-Access Middleware for Live Object-Oriented Programming

We describe middleware and programming environment tools (JPie/qt) that allow programmers to access relational databases in an object-oriented way. Building on top of the JDBC API and leveraging live dynamic class creation and modification in JPie, the JPie/qt middleware presents the user with a simple interactive mechanism for creating object-oriented applications that access databases. Classes are generated mirroring the database schema and programmers deal directly with these classes. Objects of these classes can be database-bound, so reads and writes to their fields are reflected in the relational database immediately. Database transactions are supported by connecting commit and rollback to Java exception semantics

International Differences in Longevity and Health and Their Economic Consequences

In 1975, 50 year-old Americans could expect to live slightly longer than their European counterparts. By 2005, American life expectancy at that age has diverged substantially compared to Europe. We find that this growing longevity gap is primarily the symptom of real declines in the health of near-elderly Americans, relative to their European peers. In particular, we use a microsimulation approach to project what US longevity would look like, if US health trends approximated those in Europe. We find that differences in health can explain most of the growing gap in remaining life expectancy. In addition, we quantify the public finance consequences of this deterioration in health. The model predicts that gradually moving American cohorts to the health status enjoyed by Europeans could save up to $1.1 trillion in discounted total health expenditures from 2004 to 2050.disability, mortality, international comparisons, microsimulation

Want More Value From Prescription Drugs? We Need to Let Prices Rise and Fall

The high price of some cancer drugs has recently come under attack by the medical profession. We examine the reasons behind the pricing strategies of cancer drugs. On the one hand, prices should reflect value and research demonstrates that the health benefits from novel cancer drugs have been enormous in terms of additional years of life patients can now enjoy. This provides some justification for the high price tag of these drugs. On the other hand, drug pricing is also a product of a hidebound reimbursement system that does a poor job in letting prices adjust to new information about value. Regulators set thresholds for cost-effectiveness, which establishes not only a price ceiling but also a price floor. Manufacturers often price drugs high at launch in efforts to recoup their initial investment, but a more efficient system would allow prices to both rise and fall over time. Removing distortions in the reimbursement system is crucial to ensuring continued success in saving lives

Understanding the Economic Consequences of Shifting Trends in Population Health

The public economic burden of shifting trends in population health remains uncertain. Sustained increases in obesity, diabetes, and other diseases could reduce life expectancy − with a concomitant decrease in the public-sector's annuity burden − but these savings may be offset by worsening functional status, which increases health care spending, reduces labor supply, and increases public assistance. Using a microsimulation approach, we quantify the competing public-finance consequences of shifting trends in population health for medical care costs, labor supply, earnings, wealth, tax revenues, and government expenditures (including Social Security and income assistance). Together, the reduction in smoking and the rise in obesity have increased net public-sector liabilities by $430bn, or approximately 4% of the current debt burden. Larger effects are observed for specific public programs: annual spending is 10% higher in the Medicaid program, and 7% higher for Medicare.disability, health care costs, social security, microsimulation

Weather on Other Worlds. II. Survey Results: Spots Are Ubiquitous on L and T Dwarfs

We present results from the "Weather on Other Worlds" Spitzer Exploration Science program to investigate photometric variability in L and T dwarfs, usually attributed to patchy clouds. We surveyed 44 L3-T8 dwarfs, spanning a range of $J-K_s$ colors and surface gravities. We find that 14/23 (61%; 95% confidence interval: 41%-78%) of our single L3-L9.5 dwarfs are variable with peak-to-peak amplitudes between 0.2% and 1.5%, and 5/16 (31%; 95% confidence interval: 14%-56%) of our single T0-T8 dwarfs are variable with amplitudes between 0.8% and 4.6%. After correcting for sensitivity, we find that 80% (95% confidence interval: 53%-100%) of L dwarfs vary by >0.2%, and 36% (95% confidence interval: 19%-52%) of T dwarfs vary by >0.4%. Given viewing geometry considerations, we conclude that photospheric heterogeneities causing >0.2% 3-5-micron flux variations are present on virtually all L dwarfs, and probably on most T dwarfs. A third of L dwarf variables show irregular light curves, indicating that L dwarfs may have multiple spots that evolve over a single rotation. Also, approximately a third of the periodicities are on time scales >10 h, suggesting that slowly-rotating brown dwarfs may be common. We observe an increase in the maximum amplitudes over the entire spectral type range, revealing a potential for greater temperature contrasts in T dwarfs than in L dwarfs. We find a tentative association (92% confidence) between low surface gravity and high-amplitude variability among L3-L5.5 dwarfs. Although we can not confirm whether lower gravity is also correlated with a higher incidence of variables, the result is promising for the characterization of directly imaged young extrasolar planets through variability.Comment: 42 pages, 11 figures, 2 tables, accepted by Ap

Variability in antifungal and antiviral use in hospitalized children

We analyzed antifungal and antiviral prescribing among high-risk children across freestanding children’s hospitals. Antifungal and antiviral days of therapy varied across hospitals. Benchmarking antifungal and antiviral use and developing antimicrobial stewardship strategies to optimize use of these high cost agents is needed.Infect Control Hosp Epidemiol2017;38:743–746</jats:p

Nuclear lamins: Structure and function in mechanobiology

Nuclear lamins are type V intermediate filament proteins that polymerize into complex filamentous meshworks at the nuclear periphery and in less structured forms throughout the nucleoplasm. Lamins interact with a wide range of nuclear proteins and are involved in numerous nuclear and cellular functions. Within the nucleus, they play roles in chromatin organization and gene regulation, nuclear shape, size, and mechanics, and the organization and anchorage of nuclear pore complexes. At the whole cell level, they are involved in the organization of the cytoskeleton, cell motility, and mechanotransduction. The expression of different lamin isoforms has been associated with developmental progression, differentiation, and tissue-specific functions. Mutations in lamins and their binding proteins result in over 15 distinct human diseases, referred to as laminopathies. The laminopathies include muscular (e.g., Emery-Dreifuss muscular dystrophy and dilated cardiomyopathy), neurological (e.g., microcephaly), and metabolic (e.g., familial partial lipodystrophy) disorders as well as premature aging diseases (e.g., Hutchinson-Gilford Progeria and Werner syndromes). How lamins contribute to the etiology of laminopathies is still unknown. In this review article, we summarize major recent findings on the structure, organization, and multiple functions of lamins in nuclear and more global cellular processes

Discovery of a High Proper Motion L Dwarf Binary: 2MASS J15200224-4422419AB

We report the discovery of the wide L1.5+L4.5 binary 2MASS J15200224-4422419AB, identified during spectroscopic followup of high proper motion sources selected from the Two Micron All Sky Survey. This source was independently identified by Kendall et al. in the SuperCOSMOS Sky Survey. Resolved JHK photometry and low resolution near-infrared spectroscopy demonstrate that this system is composed of two well-separated (1"174+/-0"016) L dwarfs. Component classifications are derived using both spectral ratios and comparison to near-infrared spectra of previously classified field L dwarfs. Physical association for the pair is deduced from the large (mu = 0"73+/-0"03 /yr) common proper motion of the components and their similar spectrophotometric distances (19+/-2 pc). The projected separation of the binary, 22+/-2 AU, is consistent with maximum separation/total system mass trends for very low mass binaries. The 2MASS J1520-4422 system exhibits both large tangential (66+/-7 km/s) and radial velocities (-70+/-18 km/s), and its motion in the local standard of rest suggests that it is an old member of the Galactic disk population. This system joins a growing list of well-separated (>0"5), very low mass binaries, and is an excellent target for resolved optical spectroscopy to constrain its age as well as trace activity/rotation trends near the hydrogen-burning limit.Comment: 35 pages, 8 figures; accepted for publication to ApJ; see also Kendall et al. astro-ph/060939

Virtual Surgical Planning in Subscapular System Free Flap Reconstruction of Midface Defects.

OBJECTIVES: Reconstruction of the midface has many inherent challenges, including orbital support, skull base reconstruction, optimizing midface projection, separation of the nasal cavity and dental rehabilitation. Subscapular system free flaps (SF) have sufficient bone stock to support complex reconstruction and the option of separate soft tissue components. This study analyzes the effect of virtual surgical planning (VSP) in SF for midface on subsite reconstruction, bone segment contact and anatomic position. MATERIALS AND METHODS: Retrospective cohort of patients with midface defects that underwent SF reconstruction at a single tertiary care institution. RESULTS: Nine cases with VSP were compared to fourteen cases without VSP. VSP was associated with a higher number of successfully reconstructed subunits (5.9 vs 4.2, 95% CI of mean difference 0.31-3.04, p = 0.018), a higher number of successful bony contact between segments (2.2 vs 1.4, 95% CI of mean difference 0.0-1.6, p = 0.050), and a higher percent of segments in anatomic position (100% vs 71%, 95% CI of mean difference 2-55%, p = 0.035). When postoperative bone position after VSP reconstruction was compared to preoperative scans, the difference in anteroposterior, vertical and lateral projection compared to the preoperative \u27ideal\u27 bone position was82% of measurements. There were no flap losses. CONCLUSION: VSP may augment SF reconstruction of the midface by allowing for improved subunit reconstruction, bony segment contact and anatomically correct bone segment positioning. VSP can be a useful adjunct for complex midface reconstruction and the benefits should be weighed against cost