3,179 research outputs found
Inextricably Season 1, Episode 1: “Now what”
This is the transcript of a fictional weekly podcast called Inextricably, performed in front of a live audience at North Cascades Institute’s Environmental Learning Center in North Cascades National Park in March 2017. The author outlines and examines the personal themes and seasonal cycles throughout an entire graduate school residency, a Master’s of Education in Environmental Education offered in partnership with North Cascades Institute and Western Washington University. A search for the purpose in the way information and knowledge is transferred, a sense of disillusionment with traditional models of education, and the unexpected learning outcomes of this experience are the basis of Season 1, Episode 1: “Now What?”
“Each week on Inextricably, we feature stories about events and experiences in our lives that serve as a catalyst, a tipping point, or a kick in the teeth; that send our lives in a direction we hadn’t anticipated. Experiences, relationships, traumas that are impossible to disentangle from who we have become. Each episode we welcome a new guest to the show to talk about those things we are inextricably linked to. Things we sometimes wish we weren’t. Today’s program in 11 short acts feature’s yours truly, and the graduate school experience I had, and almost didn’t have. Join me, won’t you?
Mediators Between Adversity and Well-Being of College Students
Although the concurrent link between adverse childhood experiences (ACEs) and both physical and mental health is established, little is known about the mechanisms that explain it. We investigated the relationship between ACEs and well-being and the mediating roles of coping, executive function (EF), and cognitive failure in a non-clinical sample of college students. Participants (N = 194) completed behavioral measures and self-reports. More than half of the sample had at least one ACE. Correlational and mediational analyses examined the relationships between ACEs, college adaptation, psychopathology, substance use, coping, and cognitive failure. ACEs did not correlate with indices of EF or cognitive failure, but there was a positive relationship between cognitive failure and negative coping. ACEs positively correlated with college adaptation, psychopathology, and substance abuse. There was a full mediation from ACE via negative coping and cognitive failure for college adaptation and psychopathology and via negative coping for alcohol and drug use. ACEs relate with reliance on negative coping which in turn predicts directly and indirectly, through cognitive failure, poor adaptation and heightened symptomatology for psychopathology
Visual survey of exposed riverine sediments (Ers) in the Dane, Weaver and Bollin catchments
This is the Visual survey ERS Dane, Weaver & Bollin Catchments produced by the Environment Agency in 2005. Visual surveys of the River Dane downstream of the confluence with the Swettenham Brook, the River Weaver, and the River Bollin catchment in the EA Northwest South area of England were undertaken between 3rd and 9th February 2005 with the aim of identifying the spatial distribution and relative quality of exposed Riverine sediments (ERS). The potential value of these ERS in terms of likely habitat quality for ERS invertebrate communities was determined by recording a suite of appropriate environmental variables. Following an initial cartographical analysis of reaches likely to contain ERS, tens of kilometres of riverbank were inspected and 67 areas of ERS were selected for detailed visual survey. Site characteristics ranged widely both between and within catchments, with habitat quality ranging from poor to very high
Motives and Correlates of Anabolic-Androgenic Steroid Use With Stimulant Polypharmacy
Individuals who use anabolic-androgenic steroids (AAS) may engage in concurrent psychoactive drug use recreationally and/or as an additional training aid. Aside from cannabis, individuals who use AAS most commonly report concurrent use of stimulants such as amphetamines and cocaine. In this study, we examine demographic characteristics, frequency of heavy drinking, and nightclubbing in a sample of 993 men from the Global Drug Survey 2015 who reported both AAS and psychoactive drug use before exploring the relationship between motivation for AAS use and the propensity to concurrently engage with stimulant-type substances. Results of a logistic regression analysis suggest that the propensity for concurrent use of AAS and stimulants is greater when AAS use is motivated by weight loss goals, while performance goals are associated with reduced odds of concurrent stimulant use. Identifying individuals who are at risk of polydrug use and associated harms can inform targeted harm reduction strategies
The ecology and conservation of beetles (coleoptera) living on exposed riverine sediments
Situated at the very juncture of the aquatic and terrestrial, exposed riverine sediments (ERS) are poorly vegetated alluvial deposits of silts, sands and gravels, which are habitat for a wide range of rare and highly specialised beetles. The thesis aimed to assess: (1) the conservation value of ERS beetles; (2) their changing habitat requirements and spatial population structure over a range of spatio-temporal scales; and (3) their vulnerability to anthropogenic threats, in particular, trampling by livestock. A database of British occurrence records was used to assess the conservation value of ERS specialist beetles. Beetle sampling implemented quadrat hand searches and modified dry pitfall traps, and spatial distribution and population structure in relation to a suite of environmental variables was analysed using correlation, SADIE analysis, and mark recapture methods. ERS beetles were found to have considerable conservation importance and their spatial distribution was related to habitat characteristics at the within-patch, patch, reach, and stream segment scales. These distributions varied temporally in response to flow level and trampling intensity, and trampling intensity was shown to reduce the conservation value of beetle assemblages. The likely responses to a variety of threats, such as regulation and channelization, mediated by varying inter-patch spatial population structure were evaluated
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Electronic problem list documentation of chronic kidney disease and quality of care
Background: Chronic kidney disease (CKD) is increasingly common and under-recognized in primary care clinics, leading to low rates of stage-appropriate monitoring and treatment. Our objective was to determine whether electronic problem list documentation of CKD is associated with monitoring and treatment. Methods: This is a cross-sectional observational study of patients with stage 3 or 4 CKD, defined as two past estimated glomerular filtration rates (eGFR) 15-60 mL/min/1.73 m2 separated by 90 days and collected between 2007-2008. We examined the association of problem list documentation with: 1) serum eGFR monitoring test, 2) urine protein or albumin monitoring test, 3) an angiotensin converting enzyme inhibitor or angiotensin receptor blocker (ACE/ARB) prescription, 4) mean systolic blood pressure (BP), and 5) BP control. Results: Out of 3,149 patients with stage 3 or 4 CKD, only 16% of patients had CKD documented on the problem list. After adjustment for eGFR, gender, and race/ethnicity and after clustering by physician, problem list documentation of CKD was associated with serum eGFR testing (97% with problem list documentation vs. 94% without problem list documentation, p = 0.02) and urine protein testing (47% with problem list documentation vs. 40% without problem list documentation, p = 0.04). After adjustment, problem list documentation was not associated with ACE/ARB prescription, mean systolic BP, or BP control. Conclusions: Documentation of CKD on the electronic problem list is rare. Patients with CKD documentation have better stage-appropriate monitoring of the disease, but do not have higher rates of blood pressure treatment or better blood pressure control. Interventions aimed at increasing documentation of CKD on the problem list may improve stage-appropriate monitoring, but may not improve clinical outcomes
Interactome comparison of human embryonic stem cell lines with the inner cell mass and trophectoderm
Networks of interacting co-regulated genes distinguish the inner cell mass (ICM) from the
differentiated trophectoderm (TE) in the preimplantation blastocyst, in a species specific manner. In mouse the ground state pluripotency of the ICM appears to be maintained in murine embryonic stem cells (ESCs) derived from the ICM. This is not the case for human ESCs. In order to gain insight into this phenomenon, we have used quantitative network analysis to identify how similar human (h)ESCs are to the human ICM. Using the hESC lines MAN1, HUES3 and HUES7 we have shown that all have only a limited overlap with ICM specific gene expression, but that this overlap is enriched for network
properties that correspond to key aspects of function including transcription factor activity and the hierarchy of network modules. These analyses provide an important framework which highlights the developmental origins of hESCs
Conformal Risk Control
We extend conformal prediction to control the expected value of any monotone
loss function. The algorithm generalizes split conformal prediction together
with its coverage guarantee. Like conformal prediction, the conformal risk
control procedure is tight up to an factor. Worked examples
from computer vision and natural language processing demonstrate the usage of
our algorithm to bound the false negative rate, graph distance, and token-level
F1-score.Comment: Code available at https://github.com/aangelopoulos/conformal-ris
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