Recent progress in silica aerogel Cherenkov radiator

In this paper, we present recent progress in the development of hydrophobic silica aerogel as a Cherenkov radiator. In addition to the conventional method, the recently developed pin-drying method for producing high-refractive-index aerogels with high transparency was studied in detail. Optical qualities and large tile handling for crack-free aerogels were investigated. Sufficient photons were detected from high-performance aerogels in a beam test.Comment: Proceedings of 2nd International Conference on Technology and Instrumentation in Particle Physics (TIPP 2011), to be published in Physics Procedia, 8 pages, 7 figure

Newly-established Chinese hamster-derived cell line for protein production

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Option Package Bundling

This paper analyzes the optimality of package bundling by focusing on the ?main and accessory?relationship between two goods. In particular, we consider option package bundling in which an optional good is valuable only if it is consumed together with a certain (nonoptional) base good. We develop a model of option package bundling for a monopolist in which buyers?valuations are independently and uniformly distributed. We also allow inter-relationship between valuations by assuming that the reservation value of the bundle can be greater or less than the sum of the innate value of both goods. Our analysis observes that mixed bundling, in which the base good is sold with or without the optional good, yields a higher pro?t than pure bundling if and only if the range of the optional good valuation exceeds a threshold value. We then conduct a welfare analysis of the bundling choice. The result is surprising: pure bundling is always desirable from the social welfare viewpoint when a monopolist chooses mixed bundling.Multiproduct monopoly; Bundling; Optional goods; Interdepen-dent valuations.

Visualisation of cerebrospinal fluid flow patterns in albino Xenopus larvae in vivo

<p>Abstract</p> <p>Background</p> <p>It has long been known that cerebrospinal fluid (CSF), its composition and flow, play an important part in normal brain development, and ependymal cell ciliary beating as a possible driver of CSF flow has previously been studied in mammalian fetuses <it>in vitro</it>. Lower vertebrate animals are potential models for analysis of CSF flow during development because they are oviparous. Albino <it>Xenopus laevis </it>larvae are nearly transparent and have a straight, translucent brain that facilitates the observation of fluid flow within the ventricles. The aim of these experiments was to study CSF flow and circulation <it>in vivo </it>in the developing brain of living embryos, larvae and tadpoles of <it>Xenopus laevis </it>using a microinjection technique.</p> <p>Methods</p> <p>The development of <it>Xenopus </it>larval brain ventricles and the patterns of CSF flow were visualised after injection of quantum dot nanocrystals and polystyrene beads (3.1 or 5.8 μm in diameter) into the fourth cerebral ventricle at embryonic/larval stages 30-53.</p> <p>Results</p> <p>The fluorescent nanocrystals showed the normal development of the cerebral ventricles from embryonic/larval stages 38 to 53. The polystyrene beads injected into stage 47-49 larvae revealed three CSF flow patterns, left-handed, right-handed and non-biased, in movement of the beads into the third ventricle from the cerebral aqueduct (aqueduct of Sylvius). In the lateral ventricles, anterior to the third ventricle, CSF flow moved anteriorly along the outer wall of the ventricle to the inner wall and then posteriorly, creating a semicircle. In the cerebral aqueduct, connecting the third and fourth cerebral ventricles, CSF flow moved rostrally in the dorsal region and caudally in the ventral region. Also in the fourth ventricle, clear dorso-ventral differences in fluid flow pattern were observed.</p> <p>Conclusions</p> <p>This is the first visualisation of the orchestrated CSF flow pattern in developing vertebrates using a live animal imaging approach. CSF flow in <it>Xenopus </it>albino larvae showed a largely consistent pattern, with the exception of individual differences in left-right asymmetrical flow in the third ventricle.</p

Mis16 and Mis18 Are Required for CENP-A Loading and Histone Deacetylation at Centromeres

AbstractCentromeres contain specialized chromatin that includes the centromere-specific histone H3 variant, spCENP-A/Cnp1. Here we report identification of five fission yeast centromere proteins, Mis14–18. Mis14 is recruited to kinetochores independently of CENP-A, and, conversely, CENP-A does not require Mis14 to associate with centromeres. In contrast, Mis15, Mis16 (strong similarity with human RbAp48 and RbAp46), Mis17, and Mis18 are all part of the CENP-A recruitment pathway. Mis15 and Mis17 form an evolutionarily conserved complex that also includes Mis6. Mis16 and Mis18 form a complex and maintain the deacetylated state of histones specifically in the central core of centromeres. Mis16 and Mis18 are the most upstream factors in kinetochore assembly as they can associate with kinetochores in all kinetochore mutants except for mis18 and mis16, respectively. RNAi knockdown in human cells shows that Mis16 function is conserved as RbAp48 and RbAp46 are both required for localization of human CENP-A