Ethyl 5-cyano-8-nitro-2,3,4,4a,5,6-hexahydro-1H-pyrido[1,2-a]quinoline-5-carboxylate

In the title compound, C17H19N3O4, the piperidine ring adopts a chair conformation. The crystal structure features inversion dimers linked by pairs of weak C—H⋯N hydrogen bonds

Ethyl 4-cyano-7-nitro-1,2,3,3a,4,5-hexa­hydro­pyrrolo­[1,2-a]quinoline-4-carboxyl­ate

In the title compound, C16H17N3O4, the six-membered N-containing ring adopts a half-chair conformation. One C atom of the five-membered ring is disordered over two sites, with occupancy factors of ca 0.67 and 0.33. The major pyrroline component adopts a half-chair conformation. Inter­molecular C—H⋯O hydrogen bonds forming centrosymmetric dimers are observed in the crystal

Design and synthesis of new tricyclic quinoline derivatives from intramolecular cyclization of benzylidene malonic derivatives

879-883Quinolines are very important compounds due to their numerous biological and pharmacological applications. This article describes the synthesis of new tricyclic quinoline derivatives via intramolecular cyclization of malonic benzylidene derivatives. The malonic benzylidene derivatives 2a-c have been obtained by condensation of N-substituted aldehydes 1a-c with malononitrile or ethyl cyanoacetate. These latter have been cyclized by reflux in DMF to give the compounds 3a-f. The structures of the compounds have been determined by 1 H and 13C NMR spectroscopy, and High-Resolution Mass Spectrometry (HRMS) analysis. Two of the synthesized compounds have been identified and confirmed by X-ray crystallography