Mangiferin: A Promising Anticancer Bioactive

Of late, several biologically active antioxidants from natural products have been investigated by the researchers in order to combat the root cause of carcinogenesis, i.e., oxidative stress. Mangiferin, a therapeutically active C-glucosylated xanthone, is extracted from pulp, peel, seed, bark and leaf of Mangifera indica. These polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the DNA damage. Indeed, its capability to modulate several key inflammatory pathways undoubtedly helps in stalling the progression of carcinogenesis. The current review article emphasizes an updated account on the patents published on the chemopreventive action of Mangiferin, apoptosis induction made on various cancer cells, along with proposed antioxidative activities and patent mapping of other important therapeutic properties. Considering it as promising polyphenol, this paper would also summarize the diverse molecular targets of Mangiferin

Active galactic nuclei synapses: X-ray versus optical classifications using artificial neural networks

(Abridged) Many classes of active galactic nuclei (AGN) have been defined entirely throughout optical wavelengths while the X-ray spectra have been very useful to investigate their inner regions. However, optical and X-ray results show many discrepancies that have not been fully understood yet. The aim of this paper is to study the "synapses" between the X-ray and optical classifications. For the first time, the new EFLUXER task allowed us to analyse broad band X-ray spectra of emission line nuclei (ELN) without any prior spectral fitting using artificial neural networks (ANNs). Our sample comprises 162 XMM-Newton/pn spectra of 90 local ELN in the Palomar sample. It includes starbursts (SB), transition objects (T2), LINERs (L1.8 and L2), and Seyferts (S1, S1.8, and S2). The ANNs are 90% efficient at classifying the trained classes S1, S1.8, and SB. The S1 and S1.8 classes show a wide range of S1- and S1.8-like components. We suggest that this is related to a large degree of obscuration at X-rays. The S1, S1.8, S2, L1.8, L2/T2/SB-AGN (SB with indications of AGN), and SB classes have similar average X-ray spectra within each class, but these average spectra can be distinguished from class to class. The S2 (L1.8) class is linked to the S1.8 (S1) class with larger SB-like component than the S1.8 (S1) class. The L2, T2, and SB-AGN classes conform a class in the X-rays similar to the S2 class albeit with larger fractions of SB-like component. This SB-like component is the contribution of the star-formation in the host galaxy, which is large when the AGN is weak. An AGN-like component seems to be present in the vast majority of the ELN, attending to the non-negligible fraction of S1-like or S1.8-like component. This trained ANN could be used to infer optical properties from X-ray spectra in surveys like eRosita.Comment: 15 pages, 7 figures, accepted for publication in A&A. Appendix B only in the full version of the paper here: https://dl.dropboxusercontent.com/u/3484086/AGNSynapsis_OGM_online.pd

Separation of n-hexane - ethyl acetate mixture by azeotropic batch distillation with heterogeneous entrainers

In this article, a systematic study of the separation of the n-hexane - ethyl acetate mixture with an entrainer by heterogeneous azeotropic batch distillation is performed. Based upon the thermodynamic behaviour of the ternary mixtures, potential entrainers partially miscible with one or two original azeotropic components are chosen. In all cases, the entrainer adds a heterogeneous binary or ternary azeotrope that is the lowest boiling point in the ternary diagram. Therefore, it leaves the column by the overhead stream which is subcooled to get two liquid phases in the decanter. The phase with the highest amount of the original component is removed as distillate product whereas the entrainer – rich phase is continuously refluxed to the column. Considering methanol, acetonitrile, water and nitromethane as heterogeneous entrainers, screening was performed based on the composition of the unstable heteroazeotropic mixture, the ratio of both liquid phases in the condensed top vapour and the purity of the distillate product determined by the liquid – liquid envelope at the decanter temperature. The process feasibility analysis is validated by using rigorous simulation with the batch process simulator ProSimBatch. Simulation results are then corroborated in a bench experimental column for the selected entrainer, showing several advantages of heterogeneous batch distillation compared to homogeneous systems

The redshift and broad band spectral energy distribution of NRAO 150

Context. NRAO 150 is one of the brightest radio and mm AGN sources on the northern sky. It has been revealed as an interesting source where to study extreme relativistic jet phenomena. However, its cosmological distance has not been reported so far, because of its optical faintness produced by strong Galactic extinction. Aims. Aiming at measuring the redshift of NRAO 150, and hence to start making possible quantitative studies from the source. Methods. We have conducted spectroscopic and photometric observations of the source in the near-IR, as well as in the optical. Results. All such observations have been successful in detecting the source. The near-IR spectroscopic observations reveal strong H$\alpha$ and H$\beta$ emission lines from which the cosmological redshift of NRAO 150 ($z=1.517\pm0.002$) has been determined for the first time. We classify the source as a flat-spectrum radio-loud quasar, for which we estimate a large super-massive black-hole mass $\sim5\times 10^{9} \mathrm{M_\odot}$. After extinction correction, the new near-IR and optical data have revealed a high-luminosity continuum-emission excess in the optical (peaking at $\sim2000$\,\AA, rest frame) that we attribute to thermal emission from the accretion disk for which we estimate a high accretion rate, $\sim30$\,% of the Eddington limit. Conclusions. Comparison of these source properties, and its broad-band spectral-energy distribution, with those of Fermi blazars allow us to predict that NRAO 150 is among the most powerful blazars, and hence a high luminosity -although not detected yet- $\gamma$-ray emitter.Comment: 8 pages, 4 figure

The Spitzer Atlas of Stellar Spectra

We present the Spitzer Atlas of Stellar Spectra (SASS), which includes 159 stellar spectra (5 to 32 mic; R~100) taken with the Infrared Spectrograph on the Spitzer Space Telescope. This Atlas gathers representative spectra of a broad section of the Hertzsprung-Russell diagram, intended to serve as a general stellar spectral reference in the mid-infrared. It includes stars from all luminosity classes, as well as Wolf-Rayet (WR) objects. Furthermore, it includes some objects of intrinsic interest, like blue stragglers and certain pulsating variables. All the spectra have been uniformly reduced, and all are available online. For dwarfs and giants, the spectra of early-type objects are relatively featureless, dominated by Hydrogen lines around A spectral types. Besides these, the most noticeable photospheric features correspond to water vapor and silicon monoxide in late-type objects and methane and ammonia features at the latest spectral types. Most supergiant spectra in the Atlas present evidence of circumstellar gas. The sample includes five M supergiant spectra, which show strong dust excesses and in some cases PAH features. Sequences of WR stars present the well-known pattern of lines of HeI and HeII, as well as forbidden lines of ionized metals. The characteristic flat-top shape of the [Ne III] line is evident even at these low spectral resolutions. Several Luminous Blue Variables and other transition stars are present in the Atlas and show very diverse spectra, dominated by circumstellar gas and dust features. We show that the [8]-[24] Spitzer colors (IRAC and MIPS) are poor predictors of spectral type for most luminosity classes.Comment: Accepted by ApJS; Atlas contents available from: http://web.ipac.caltech.edu/staff/ardila/Atlas/index.html; http://irsa.ipac.caltech.edu/data/SPITZER/SASS/; 70 PDF pages, including figure

The cartujano stock of the spanish horse in America

The Cartujano stock of the Spanish horse is eumetric, mesomorphous, constitutionally compact and with subconvex profile. It shows a bright and energic aspect, with appreciable elevations and extensions. Its constitutional type is orthostenic or equanimous, its character is noble and docile. It is very interesting for the breaking in high school. This stock has its origin in the farm created by the Cartujanos monks from Jerez de la Frontera, in 1492. Today it can be find in Colombia on Mr. Francisco León Arboleda’s farm; in Costa Rica included in the farms of Mr. Mariano Guardia and Mr. Jorge Herrera, among others. Also in Cuba bought by Mr. Fidel Castro; in E.E.U.U. included in the farms of Mr. Currier, Mr. Broston, Mr. Parkinson, Mr. Garmendia and Mr. Alcalde, among others. In Mexico the most important breeders are Mr. Miguel Alemán, Mr. Enrique Alvarez and Mr. Plácido Arango. We also find this stock in other countries such as Nicaragua, Perú, Venezuela, etc. All that shows its important genetic contribution to the Spanish Breed horse in America.La estirpe Cartujana del Caballo Español es eumétrica, mesomorfa, constitucionalmente compacta y de perfil subconvexo. Esto le da un aspecto elegante y enérgico, con una apreciable elevación y extensión. Su tipo constitucional es ortosténico ó equilibrado, su carácter es noble y dócil. Es muy adecuada para la doma de Alta Escuela. Tiene su origen en la ganadería creada por los monjes Cartujanos de Jerez de la Frontera, en 1492. Se emplea aun como mejorante del caballo de raza española en Colombia (ganadería de D. Francisco León Arboleda) y en Costa Rica en las ganaderías del Sr. Mariano Guardia, D. Jorge Herrera y otras. También en Cuba fue comprada por el Sr. Fidel Castro; en USA se encuentra en las ganaderías de los sres. Currier, Broston, Parkinson, Garmendia, Alcalde, y otros. En México los ganaderos más importantes son D. Miguel Alemán, D. Enrique Alvarez y D. Plácido Arango. También está presente en Nicaragua, Perú, Venezuela, etc. Lo que demuestra su importante aportación genética al caballo Español en América

Chaotic Waveguide-Based Resonators for Microlasers

We propose the construction of highly directional emission microlasers using two-dimensional high-index semiconductor waveguides as {\it open} resonators. The prototype waveguide is formed by two collinear leads connected to a cavity of certain shape. The proposed lasing mechanism requires that the shape of the cavity yield mixed chaotic ray dynamics so as to have the appropiate (phase space) resonance islands. These islands allow, via Heisenberg's uncertainty principle, the appearance of quasi bound states (QBS) which, in turn, propitiate the lasing mechanism. The energy values of the QBS are found through the solution of the Helmholtz equation. We use classical ray dynamics to predict the direction and intensity of the lasing produced by such open resonators for typical values of the index of refraction.Comment: 5 pages, 5 figure