11 research outputs found
Diseño de herramientas y metodologías docentes innovadoras para la asignatura "Notación y Edición Musical" del Grado de Musicología
Diseño de herramientas y metodologías docentes innovadoras para la asignatura “Notación y Edición Musical” del Grado de Musicología (sin financiación).
Carmen Julia Gutiérrez González (coord.)
Facultad de Geografía e Historia, Departamento de Musicologí
INNOVASONORA: gestión de archivos sonoros, sonido inmersivo y realidad virtual en plataformas LMS
Memoria del proyecto de innovación docente "Innovasonora" (Curso 2021-2022
INNOVASONORA: desarrollo de recursos para la transmisión digital de los archivos sonoros y la aplicación de la realidad virtual como complemento de la enseñanza presencial
Memoria del proyecto de innovación docente nº 208 (curso 2020-2021
Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections
IMPORTANCE The consumption of broad-spectrum drugs has increased as a consequence of the spread of multidrug-resistant (MDR) Escherichia coli. Finding alternatives for these infections is critical, for which some neglected drugs may be an option. OBJECTIVE To determine whether fosfomycin is noninferior to ceftriaxone or meropenem in the targeted treatment of bacteremic urinary tract infections (bUTIs) due to MDR E coli. DESIGN, SETTING, AND PARTICIPANTS This multicenter, randomized, pragmatic, open clinical trial was conducted at 22 Spanish hospitals from June 2014 to December 2018. Eligible participants were adult patients with bacteremic urinary tract infections due to MDR E coli; 161 of 1578 screened patients were randomized and followed up for 60 days. Data were analyzed in May 2021. INTERVENTIONS Patients were randomized 1 to 1 to receive intravenous fosfomycin disodium at 4 g every 6 hours (70 participants) or a comparator (ceftriaxone or meropenem if resistant; 73 participants) with the option to switch to oral fosfomycin trometamol for the fosfomycin group or an active oral drug or pa renteral ertapenem for the comparator group after 4 days. MAIN OUTCOMES AND MEASURES The primary outcome was clinical and microbiological cure (CMC) 5 to 7 days after finalization of treatment; a noninferiority margin of 7% was considered. RESULTS Among 143 patients in the modified intention-to-treat population (median [IQR] age, 72 [62-81] years; 73 [51.0%] women), 48 of 70 patients (68.6%) treated with fosfomycin and 57 of 73 patients (78.1%) treated with comparators reached CMC (risk difference, -9.4 percentage points; 1-sided 95% CI, -21.5 to infinity percentage points; P = .10). While clinical or microbiological failure occurred among 10 patients (14.3%) treated with fosfomycin and 14 patients (19.7%) treated with comparators (risk difference, -5.4 percentage points; 1-sided 95% CI. -infinity to 4.9; percentage points; P = .19), an increased rate of adverse event-related discontinuations occurred with fosfomycin vs comparators (6 discontinuations [8.5%] vs 0 discontinuations; P = .006). In an exploratory analysis among a subset of 38 patients who underwent rectal colonization studies, patients treated with fosfomycin acquired a new ceftriaxone-resistant or meropenem-resistant gram-negative bacteria at a decreased rate compared with patients treated with comparators (0 of 21 patients vs 4 of 17 patients [23.5%]; 1-sided P = .01). CONCLUSIONS AND RELEVANCE This study found that fosfomycin did not demonstrate noninferiority to comparators as targeted treatment of bUTI from MDR E coli; this was due to an increased rate of adverse event-related discontinuations. This finding suggests that fosfomycin may be considered for selected patients with these infections
ESTRUCTURA DE COMPUTADORS I (Examen 2n quadrimestre). Examen final (Curs 2019-2020)
Resolve
ESTRUCTURA DE COMPUTADORS I (Examen 2n quadrimestre). Examen final (Curs 2019-2020)
Resolve
Innovasonora: aspectos técnicos y legales para el desarrollo de un banco de sonidos online destinado a la docencia
El proyecto de innovación docente «innovasonora» tiene como objetivo el desarrollo de nuevos materiales audiovisuales y recursos relacionados con la aplicación del audio y la grabación sonora en la práctica docente.Depto. de MusicologíaCentro de Vigilancia Sanitaria Veterinaria (VISAVET)FALSEsubmitte