Balanoposthitis as a cutaneous marker of diabetes mellitus in an apparently healthy male

Background: Balanoposthitis inflammation of the glans penis, which often involves prepuce is a common condition and are usually managed symptomatically without considering a possible association diabetes. Acquired balanoposthitis may be the first clinical presentation of undiagnosed diabetes mellitus. Methods: We enrolled 100 subjects with balanoposthitis with no history of diabetes mellitus in the past. Random blood sugar was done in all subjects, those with random blood sugar more than 140 mg/dl underwent fasting and 2 hour post prandial blood sugar estimation. Result: Out of 100 patients having balanitis,7 patients were detected to have diabetes mellitus for the first time, while another 4 patients were found to have impaired glucose tolerance for the first time. Conclusion: In conclusion, we must bear in mind that balanoposthitis may be the first clinical sign of diabetes mellitus in males and hence appropriate blood glucose testing should be carried out when assessing men with balanoposthitis

An Unusual First Presentation of Ebstein′s Anomaly in a 70-year-old Patient

Ebstein′s anomaly is a congenital heart defect. The septal and posterior leaflets of the tricuspid valve are displaced toward the apex of the right ventricle called as atrailazation of right ventricle. Most of them have interatrial communication. Ebstein′s anomaly accounts for 70 years. A 70-year-old male presented with dyspnea on exertion was a case of Ebstein′s anomaly with the late presentation in seventh decade of life

Research Paper - Effect of Bramhi Ghrita, an polyherbal formulation on learning and memory paradigms in experimental animals

OBJECTIVE: To investigate the neuropsychopharmacological effect of a polyherbal formulation Bramhi Ghrita (BG) on learning and memory processes in rats by elevated plus maze, and in mice by Morris water maze model. MATERIAL AND METHODS: BG contains Bacopa monneri (Bramhi), Evolvulus alsinoids, Acorus calamus, Saussurea lappa and cow's ghee. Its effect (30, 50 and 100 mg/kg, p.o.) was tested on learning and memory processes. The activity of BG on memory acquisition and retention was studied using elevated plus maze model (EPM) in rats, and on spatial memory using Morris water maze model (MWM) in mice. The alcoholic extract of Bacopa monneri (40 mg/kg, p.o.) was also administered to one group of animals. The results were compared with the vehicle-treated group. RESULTS: Administration of Bramhi Ghrita (50 and 100 mg/kg, p.o.) showed significant reduction in transfer latency in EPM and escape latency in MWM as compared with the control group. CONCLUSION: BG may act as a memory enhancer formulation and may also be useful as a supportive adjuvant in the treatment of impaired memory functions

Research Paper - Evaluation of CNS activity of Bramhi Ghrita

OBJECTIVE: To eavaluate the CNS activity of Bramhi Ghrita, a polyherbal formulation containing Bacopa monneri , Evolvulus alsinoids , Acorus calamus , Saussurea lappa and cow′s ghee. MATERIALS AND METHODS: The effect of Bramhi Ghrita on motor coordination, behavior, sleep, convulsions, locomotion and analgesia was evaluated in mice using standard procedures. RESULTS: The formulation exhibited reduced alertness, spontaneous locomotor activity and reactivity. It also antagonized the behavioral effects of d-amphetamine, potentiated the pentobarbitone-induced sleep and increased the pain threshold. Bramhi Ghrita protected mice from maximum electroshock and pentylene tetrazole-induced convulsions. CONCLUSION: The Bramhi Ghrita was found to be a CNS depressant with anticonvulsant. activit

Neuropharmacological actions of Panchagavya formulation containing <i>Emblica officinalis </i>Gaerth and <i>Glycyrrhiza glabra </i>Linn in mice

499-503A panchagavya Ayurvedic formulation containing E. officinalis, G. glabra, and cow’s ghee was evaluated for its effect on pentobarbital-induced sleeping time, pentylenetetrazol-induced seizures, maximal electroshock-induced seizures, spontaneous motor activity, rota-rod performance (motor coordination) and antagonism to amphetamine in mice. The formulation (300, 500 mg/kg, po) produced a significant prolongation of pentobarbital-induced sleeping time and reduced spontaneous locomotor activity. The formulation also significantly antagonised the amphetamine induced hyper-locomotor activity (500, 750 mg/kg, po) and protected mice against tonic convulsions induced by maximal electroshock (500, 750 mg/kg, po). The formulation slightly prolonged the phases of seizure activity but did not protect mice against lethality induced by pentylenetetrazole. The formulation did not show neurotoxicity. The results suggest that the panchagavya formulation is sedative in nature

<i style="">In vitro</i> antibacterial activity of <i style="">Takrarishta</i> – An <i style="">Ayurvedic</i> formulation

325-328Takrarishta is an Ayurvedic formulation which contains Go-Takra (buttermilk prepared from curd of cow’s milk), Amla, Harda, Marich, Ajowan, Saindhava namak, Sauvarcala namak, Bida namak, Audbhida namak and Samudra namak and is indicated against haemorrhoids, worm infestation, loss of appetite, irritable bowel syndrome and diarrhoea. In present investigation, Takrarishta formulation has been screened for antibacterial activity against ten bacterial species namely Staphylococcus aureus, Salmonella typhi, Bacillus subtilis (MTCC 441), Pseudomonas aeruginosa (MTCC 424), Proteus vulgaris (MTCC 1771), Micrococcus luteus (MTCC 1541), Bacillus cereus (MTCC 430) Escherichia coli (MTCC 739), Shigella flexneri (MTCC 1457) and Clostridium perfringens (NCIM 2677). The formulation as well as individual component exhibited antibacterial activity against different strains. The formulation has been suggested to be useful in gastrointestinal (GI) infections and in the condition of food poisoning