Optimal Technology Selection and Operation of Bio-methane CHP Units for Commercial Buildings

This paper explores the optimal implementation of bio-methane fuelled combined heat and power (CHP) systems to satisfy heat and electricity demands of commercial buildings; with the overarching goal of making cost-effective investments and decarbonizing building operations. The research work consisted in the development of a CHP technology selection and operation (TSO) optimization model. Its results can be utilized to develop a strategy for investment in bio-methane CHP projects for a portfolio of buildings. The TSO model enables a new approach for the selection and operation of CHP units that encompasses whole life costing, carbon emissions as well as real-time energy prices and demands, providing a more comprehensive result than current methods. Utilizing historic metered energy demands, projected energy prices and a portfolio of available CHP technologies, the mathematical model simultaneously solves for an optimal CHP unit selection and operational strategy for a determined building based on a preferred objective: minimizing cost, minimizing GHG emissions, or a mix of both. Results of this model prove that attractive cost and emissions savings are possible through the optimal selection and operation of CHP technologies fuelled by bio-methan

A Technology Selection and Operation (TSO) optimisation model for distributed energy systems: Mathematical formulation and case study

This paper presents a model which simultaneously optimises the selection and operation of technologies for distributed energy systems in buildings. The Technology Selection and Operation (TSO) model enables a new approach for the optimal selection and operation of energy system technologies that encompasses whole life costing, carbon emissions as well as real-time energy prices and demands; thus, providing a more comprehensive result than current methods. Utilizing historic metered energy demands, projected energy prices and a portfolio of available technologies, the mathematical model simultaneously solves for an optimal technology selection and operational strategy for a determined building based on a preferred objective: minimizing cost and/or minimizing carbon emissions. The TSO is a comprehensive and novel techno-economic model, capable of providing decision makers an optimal selection from a portfolio of available energy technologies. The current portfolio of available technologies is composed of various combined heat and power (CHP) and organic Rankine cycle (ORC) units. The TSO model framework is data-driven and therefore presents a high level of flexibility with respect to time granularity, period of analysis and the technology portfolio. A case study depicts the capabilities of the model; optimisation results under different temporal arrangements and technology options are showcased. Overall, the TSO model provides meaningful insights that allow stakeholders to make technology investment decisions with greater assurance

Cross-linguistic transfer in bilingual reading is item specific

First published online: 26 April 2021The grain size of orthographic representations prompted by a consistent orthography (like Spanish or Basque) increases if reading is simultaneously learned in another language with an inconsistent orthography (like French). Here, we aimed to identify item properties that trigger this grain-size accommodation in bilingual reading. Twenty-five French–Basque and 25 Spanish–Basque bilingual children attending Grade 3 read Basque words and pseudowords containing “complex” letter clusters mapping to one sound in French but several sounds in Basque or Spanish, and “simple” letter clusters mapping to the same sound structure in all three languages. Only French speaking children read “complex” Basque words faster than “simple” ones, suggesting that they accessed multi-letter “French” units to boost lexical processing. A negative complexity effect was found for pseudowords across groups. We discuss the existence of flexible cross-linguistic transfer in bilingual reading, proposing that the grain size of orthographic representations adjusts to item-specific characteristics during reading.This research was support by the Basque Government (BERC 2018-2021 program to BCBL, and PIBA_2018_1_0029 to C.D.M.), the H2020 European Research Council program (ERC-2018-COG-819093 to C.D.M.) and Spanish Ministry for Science and Innovation (PSI2017-82941-P and RED2018-102615-T to C.D.M., RTI2018-096242-B-I00 to M.L., RYC-2015-17356 to M.L., and SEV-2015-0490 to the BCBL)

Large T Antigen-Specific Cytotoxic T Cells Protect Against Dendritic Cell Tumors through Perforin-Mediated Mechanisms Independent of CD4 T Cell Help.

Our newly generated murine tumor dendritic cell (MuTuDC) lines, generated from tumors developing in transgenic mice expressing the simian virus 40 large T antigen (SV40LgT) and GFP under the DC specific promoter CD11c, reproduce the phenotypic and functional properties of splenic wild type CD8α(+) conventional DCs. They have an immature phenotype with low co-stimulation molecule expression (CD40, CD70, CD80, and CD86) that is upregulated after activation with toll-like receptor ligands. We observed that after transfer into syngeneic C57BL/6 mice, MuTuDC lines were quickly rejected. Tumors grew efficiently in large T transgene-tolerant mice. To investigate the immune response toward the large T antigen that leads to rejection of the MuTuDC lines, they were genetically engineered by lentiviral transduction to express luciferase and tested for the induction of DC tumors after adoptive transfer in various gene deficient recipient mice. Here, we document that the MuTuDC line was rejected in C57BL/6 mice by a CD4 T cell help-independent, perforin-mediated CD8 T cell response to the SV40LgT without pre-activation or co-injection of adjuvants. Using depleting anti-CD8β antibodies, we were able to induce efficient tumor growth in C57BL/6 mice. These results are important for researchers who want to use the MuTuDC lines for in vivo studies

Detection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor

This study presents a novel approach based on a four-electrode electrochemical biosensor for the detection of tau protein – one of the possible markers for the prediction of Alzheimer's disease (AD). The biosensor is based on the formation of stable antibody–antigen complexes on gold microband electrodes covered with a layer of a self-assembled monolayer and protein G. Antibodies were immobilized on the gold electrode surface in an optimal orientation by protein G interaction. Electrochemical impedance spectroscopy was used to analyze impedance change, which revealed a linear response with increasing tau concentrations. The assay is fast (<1 h for incubation and measurement) and very sensitive. The limit of quantification for the full-length 2N4R tau protein is 0.03 pM, a value unaltered when the assay was processed in bovine serum albumin or human serum. This technology could be adapted for the detection of other biomarkers to provide a multiple assay to identify AD progression in a point of care setting

Luminescent Optical Fiber Oxygen Sensor following Layer-by-layer Method

AbstractA sensor based on luminescence has been prepared depositing the luminescent complex platinum tetrakis pentrafluorophenyporphine (PtTFPP) onto a plastic-clad silica (PCS) optical fiber. The sensing film is constructed in terms of Layer-by-Layer method. A LED centered at 400nm was used to interrogate the sensor in a reflection configuration, registering a luminescent signal from the sensing material located at 648nm. The transduction principle is based on the quenching suffered by PtTFPP as the oxygen (O2) concentration increases. The sensor was characterized for O2 concentrations from 0% to 75%, showing a linear Stern–Volmer relationship (R2 = 0.9962)

High pressure effects in fluorinated HgBa2Ca2Cu3O(8+d)

We have measured the pressure sensitivity of Tc in fluorinated HgBa2Ca2Cu3O(8+d) (Hg-1223) ceramic samples with different F contents, applying pressures up to 30 GPa. We obtained that Tc increases with increasing pressure, reaching different maximum values, depending on the F doping level, and decreases for a further increase of pressure. A new high Tc record (166 K +/- 1 K) was achieved by applying pressure (23 GPa) in a fluorinated Hg-1223 sample near the optimum doping level. Our results show that all our samples are at the optimal doping, and that fluorine incorporation decreases the crystallographic $a$-parameter concomitantly increasing the maximum attainable Tc. This effect reveals that the compression of the $a$ axes is one of the keys that controls the Tc of high temperature superconductors.Comment: 4 pages, 4 figures, submitted to Phys. Rev.

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.

Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 deficiency has been reported to promote chronic inflammation-related disorders, but whether SIRT3 impacts on innate immune responses and host defenses against infections remains essentially unknown. This aspect is of primary importance considering the great interest in developing SIRT3-targeted therapies. Using SIRT3 knockout mice, we show that SIRT3 deficiency does not affect immune cell development and microbial ligand-induced proliferation and cytokine production by splenocytes, macrophages and dendritic cells. Going well along with these observations, SIRT3 deficiency has no major impact on cytokine production, bacterial burden and survival of mice subjected to endotoxemia, Escherichia coli peritonitis, Klebsiella pneumoniae pneumonia, listeriosis and candidiasis of diverse severity. These data suggest that SIRT3 is not critical to fight infections and support the safety of SIRT3-directed therapies based on SIRT3 activators or inhibitors for treating metabolic, oncologic and neurodegenerative diseases without putting patients at risk of infection