Purposive Pattern Recognition: The Nature of Visual Choice in Graphic Design

Every pamphlet, brochure, booklet, advert, package, poster, etc that has ever been produced involved a visual choice made by a human being - even if the choice were restricted to ‘doing it like the last time’ or ‘copy this one’. Whether graphic designer, information designer, advertising executive, programmer, printer or the Managing Director’s wife, someone decided this picture, this type face, this layout etc rather than some available alternative. How are visual choices made? And, in particular, how do professional graphic designers make choices between visual alternatives. It was decided to probe this question by interviewing professional designers and looking at their work. The initial plan involved some sophisticated analysis of variables but it soon became apparent that such an approach was not possible. Specific interview questions such as, “You decided to use a picture of an elephant. Why an elephant and why this particular one?” met with responses along the lines of, “It just felt right” or “It’s intuitive”. It became clear that although some designers can tell a story about their choices, most designers make use of their experience and the experience of others to arrive at a decision that is not the result of some carefully thought out decision tree or a calculus of competing requirements. It was felt by both of us that there ought to be a better way to describe this process of ‘just knowing its right’ than intuition. Eventually we came up with Purposive Pattern Recognition, abbreviated to PPR. One of us (M A-R) gathered the evidence from interviews, case studies and existing studies of Masters in Design (a title awarded by a US magazine, following a poll of its readership) The other one (J Z L) placed the notion of PPR in a conceptual framework using current thinking in neuroscience and in evolutionary memetics. Keywords: Graphic Design, Intuition, Neuroscience, Memetics.</p

Submarine Groundwater Discharge Data at Meter Scale (223Ra, 224Ra, 226Ra, 228Ra and 222Rn) in Indian River Bay (Delaware, US)

Abstract Submarine groundwater discharge (SGD) was sampled at high-spatial resolution in Indian River Bay, DE, USA, in July 2016 to characterize the spatial variability of the activity of the radium and radon isotopes commonly used to estimate SGD. These data were part of an investigation into the methods and challenges of characterizing SGD rates and variability, especially in the coastal aquifer transition from freshwater to saltwater (Hydrogeological processes and near shore spatial variability of radium and radon isotopes for the characterization of submarine groundwater discharge (Duque et al., 2019)). Samples were collected with seepage meters and minipiezometers to obtain sufficient volumes for analytical characterization. Seepage meter samples (for 223Ra, 224Ra, 226Ra, and 228Ra) were collected at two-hour intervals over a semi-diurnal tidal cycle from 30 seepage meters. Samples for 222Rn characterization were collected with a minipiezometer from 25 cm below the bay bed at each seepage meter location. All samples were analyzed with standard and state of the art procedures

A Narrative Review of the Measles Outbreak in North America and Globally

In the early twenty-first century, measles was completely eradicated in the United States of America (USA) and almost eliminated in Canada. This was greatly due to most of the population being vaccinated against the virus. In 2018 and 2019, the USA and Canada experienced a rapidly developing measles virus outbreak due to growing debates about vaccine efficacy and side effects. Therefore, some people refused to vaccinate their children against measles, as well as many other life-threatening preventable diseases. This led to a major measles outbreak and health concern in the USA, Canada, and globally. Some countries including the Democratic Republic of the Congo (DRC) reported a significant number of cases and casualties resulting from measles, mainly due to the lack of funding for vaccines, as well as inadequate vaccination coverage in certain socio-demographic areas. People traveling from these countries can easily transmit the disease, though there has been a steep decline in cases since the travel ban due to coronavirus disease-2019 (COVID-19). The number of unvaccinated children currently in the USA and Canada has quadrupled since 2001. Over the past couple of years, most of the measles cases have been diagnosed in those who either did not receive the measles vaccine or complete the recommended doses of the vaccine. This paper reviews the measles outbreak, in recent years, among unvaccinated individuals in the USA, Canada, and globally

Medicines informal market in Congo, Burundi and Angola: counterfeit and sub-standard antimalarials

BACKGROUND: The presence of counterfeits and sub-standards in African medicines market is a dramatic problem that causes many deaths each year. The increase of the phenomenon of pharmaceutical counterfeiting is due to the rise of the illegal market and to the impossibility to purchase branded high cost medicines. METHODS: In this paper the results of a quality control on antimalarial tablet samples purchased in the informal market in Congo, Burundi and Angola are reported. The quality control consisted in the assay of active substance by means of validated liquid chromatographic methods, uniformity of mass determination, disintegration and dissolution tests. Moreover, a general evaluation on label and packaging characteristics was performed. RESULTS: The results obtained on thirty antimalarial tablet samples containing chloroquine, quinine, mefloquine, sulphadoxine and pyrimethamine showed the presence of different kinds of problems: a general problem concerning the packaging (loose tablets, packaging without Producer name, Producer Country and sometimes without expiry date); low content of active substance (in one sample); different, non-declared, active substance (in one sample); sub-standard technological properties and very low dissolution profiles (in about 50% of samples). This last property could affect the bioavailability and bioequivalence in comparison with branded products and could be related to the use of different excipients in formulation or bad storage conditions. CONCLUSION: This paper evidences that the most common quality problem in the analysed samples appears to be the low dissolution profile. Here it is remarked that the presence of the right active substance in the right quantity is not a sufficient condition for a good quality drug. Dissolution test is not less important in a quality control and often evidences in vitro possible differences in therapeutic efficacy among drugs with the same active content. Dissolution profile can be dramatically affected by the choice of excipients in the oral solid formulation and, in many cases, is out of specifications due to the absence of formulation studies by producers of developing countries

PUFA Treatment Affects C2C12 Myocyte Differentiation, Myogenesis Related Genes and Energy Metabolism

Polyunsaturated fatty acids (PUFAs) are the main components of cell membrane affecting its fluidity, signaling processes and play a vital role in muscle cell development. The effects of docosahexaenoic acid (DHA) on myogenesis are well known, while the effects of arachidonic acid (AA) are largely unclear. The purpose of this study is to evaluate the effect of two PUFAs (DHA and AA) on cell fate during myogenic processes, Wnt signaling and energy metabolism by using the C2C12 cells. The cells were treated with different concentrations of AA or DHA for 48 h during the differentiation period. PUFA treatment increased mRNA level of myogenic factor 5 (Myf5), which is involved in early stage of myoblast proliferation. Additionally, PUFA treatment prevented myoblast differentiation, indicated by decreased myotube fusion index and differentiation index in parallel with reduced mRNA levels of myogenin (MyoG). After PUFA withdrawal, some changes in cell morphology and myosin heavy chain mRNA levels were still observed. Expression of genes associated with Wnt signaling pathway, and energy metabolism changed in PUFA treatment in a dose and time dependent manner. Our data suggests that PUFAs affect the transition of C2C12 cells from proliferation to differentiation phase by prolonging proliferation and preventing differentiation

Identification and characterization of Brassica oleracea specifier proteins in the enzymatic degradation of glucosinolates

Brassica oleracea like all crucifers plants have a defense mechanism against natural enemies, which are chemical compounds formed form the enzymatic degradation of glucosinolates. In the presence of epithiospecifier proteins (ESP), the hydrolysis of glucosinolates will form epithionitriles or nitriles depending on the glucosinolate structure, This research proved that three predicted sequences (ESP) taken from NCBI database has a role in the enzymatic hydrolysis of glucosinolates in Brassica oleracea

Analyzing the Relationship between Agricultural FDI and Food Security: Evidence from Belt and Road Countries

This study analyzes the relationship between agricultural foreign direct investment (FDI) and food security on Belt and Road Initiative (BRI) countries in a panel framework over the period 2006&ndash;2015 using correlation analysis, the specific-effect model, and the 2SLS technique. The study aims to: first, analyze the correlation between agricultural FDI and food security for each country, individually; then, investigate whether there is a direct relationship, using the specific-effect model. Finally, by taking one step further, this study uses the 2SLS method to determine whether there is an indirect relationship through agricultural productivity. Our results show that the sampled countries have clear differences in the direction of the relationship between food security and agricultural FDI. But, in general, the agricultural FDI has a positive direct and indirect effect on food security; this effect is seen clearly when the country attracts agricultural FDIs steadily