Multi-objective engineering shape optimization using differential evolution interfaced to the Nimrod/O tool

This paper presents an enhancement of the Nimrod/O optimization tool by interfacing DEMO, an external multiobjective optimization algorithm. DEMO is a variant of differential evolution – an algorithm that has attained much popularity in the research community, and this work represents the first time that true multiobjective optimizations have been performed with Nimrod/O. A modification to the DEMO code enables multiple objectives to be evaluated concurrently. With Nimrod/O’s support for parallelism, this can reduce the wall-clock time significantly for compute intensive objective function evaluations. We describe the usage and implementation of the interface and present two optimizations. The first is a two objective mathematical function in which the Pareto front is successfully found after only 30 generations. The second test case is the three-objective shape optimization of a rib-reinforced wall bracket using the Finite Element software, Code_Aster. The interfacing of the already successful packages of Nimrod/O and DEMO yields a solution that we believe can benefit a wide community, both industrial and academic

Scheduling aircraft landings - the static case

This is the publisher version of the article, obtained from the link below.In this paper, we consider the problem of scheduling aircraft (plane) landings at an airport. This problem is one of deciding a landing time for each plane such that each plane lands within a predetermined time window and that separation criteria between the landing of a plane and the landing of all successive planes are respected. We present a mixed-integer zero–one formulation of the problem for the single runway case and extend it to the multiple runway case. We strengthen the linear programming relaxations of these formulations by introducing additional constraints. Throughout, we discuss how our formulations can be used to model a number of issues (choice of objective function, precedence restrictions, restricting the number of landings in a given time period, runway workload balancing) commonly encountered in practice. The problem is solved optimally using linear programming-based tree search. We also present an effective heuristic algorithm for the problem. Computational results for both the heuristic and the optimal algorithm are presented for a number of test problems involving up to 50 planes and four runways.J.E.Beasley. would like to acknowledge the financial support of the Commonwealth Scientific and Industrial Research Organization, Australia

Immune Dysregulation in Patients Persistently Infected with Human Papillomaviruses 6 and 11

Human Papillomaviruses (HPVs) 6 and 11 are part of a large family of small DNA viruses, some of which are commensal. Although much of the population can contain or clear infection with these viruses, there is a subset of individuals who develop persistent infection that can cause significant morbidity and on occasion mortality. Depending on the site of infection, patients chronically infected with these viruses develop either recurrent, and on occasion, severe genital warts or recurrent respiratory papillomas that can obstruct the upper airway. The HPV-induced diseases described are likely the result of a complex and localized immune suppressive milieu that is characteristic of patients with persistent HPV infection. We review data that documents impaired Langerhans cell responses and maturation, describes the polarized adaptive T-cell immune responses made to these viruses, and the expression of class select II MHC and KIR genes that associate with severe HPV6 and 11 induced disease. Finally, we review evidence that documents the polarization of functional TH2 and T-regulatory T-cells in tissues persistently infected with HPV6 and 11, and we review evidence that there is suppression of natural killer cell function. Together, these altered innate and adaptive immune responses contribute to the cellular and humoral microenvironment that supports HPV 6 and 11-induced disease

The Grism Lens-Amplified Survey from Space (GLASS). XII. Spatially Resolved Galaxy Star Formation Histories and True Evolutionary Paths at z > 1

Modern data empower observers to describe galaxies as the spatially and biographically complex objects they are. We illustrate this through case studies of four, $z\sim1.3$ systems based on deep, spatially resolved, 17-band + G102 + G141 Hubble Space Telescope grism spectrophotometry. Using full spectrum rest-UV/-optical continuum fitting, we characterize these galaxies' observed $\sim$kpc-scale structures and star formation rates (SFRs) and reconstruct their history over the age of the universe. The sample's diversity---passive to vigorously starforming; stellar masses $\log M_*/M_\odot=10.5$ to $11.2$---enables us to draw spatio-temporal inferences relevant to key areas of parameter space (Milky Way- to super-Andromeda-mass progenitors). Specifically, we find signs that bulge mass-fractions ($B/T$) and SF history shapes/spatial uniformity are linked, such that higher $B/T$s correlate with "inside-out growth" and central specific SFRs that peaked above the global average for all starforming galaxies at that epoch. Conversely, the system with the lowest $B/T$ had a flat, spatially uniform SFH with normal peak activity. Both findings are consistent with models positing a feedback-driven connection between bulge formation and the switch from rising to falling SFRs ("quenching"). While sample size forces this conclusion to remain tentative, this work provides a proof-of-concept for future efforts to refine or refute it: JWST, WFIRST, and the 30-m class telescopes will routinely produce data amenable to this and more sophisticated analyses. These samples---spanning representative mass, redshift, SFR, and environmental regimes---will be ripe for converting into thousands of sub-galactic-scale empirical windows on what individual systems actually looked like in the past, ushering in a new dialog between observation and theory.Comment: 18 pp, 15 figs, 3 tables (main text); 5 pp, 5 figs, 1 table (appendix); Submitted to AAS Journals 1 October 201