23 research outputs found
Analysis of mesoscale effects in high-shear granulation through a computational fluid dynamics-population balance coupled compartment model
There is a need for mesoscale resolution and coupling between flow-field information and the evolution of particle properties in high-shear granulation. We have developed a modelling framework that compartmentalizes the high-shear granulation process based on relevant process parameters in time and space. The model comprises a coupled-flow-field and population-balance solver and is used to resolve and analyze the effects of mesoscales on the evolution of particle properties. A Diosna high-shear mixer was modelled with microcrystalline cellulose powder as the granulation material. An analysis of the flow-field solution and compartmentalization allows for a resolution of the stress and collision peak at the impeller blades. Different compartmentalizations showed the importance of resolving the impeller region, for aggregating systems and systems with breakage. An independent study investigated the time evolution of the flow field by changing the particle properties in three discrete steps that represent powder mixing, the initial granulation stage mixing and the late stage granular mixing. The results of the temporal resolution study show clear changes in collision behavior, especially from powder to granular mixing, which indicates the importance of resolving mesoscale phenomena in time and space
Fostering and sustaining innovation in a Fast Growing Agile Company
Sustaining innovation in a fast growing software development company is
difficult. As organisations grow, peoples' focus often changes from the big
picture of the product being developed to the specific role they fill. This
paper presents two complementary approaches that were successfully used to
support continued developer-driven innovation in a rapidly growing Australian
agile software development company. The method "FedEx TM Day" gives developers
one day to showcase a proof of concept they believe should be part of the
product, while the method "20% Time" allows more ambitious projects to be
undertaken. Given the right setting and management support, the two approaches
can support and improve bottom-up innovation in organizations