1,157 research outputs found
Epidemiology of tumor-induced osteomalacia in denmark
Tumor-induced osteomalacia (TIO) is a rare, acquired condition of phosphate wasting due to phosphaturic mesenchymal tumors. Because the incidence and prevalence of TIO is unknown, we conducted an observational cohort study using national Danish health registers for the period 2008 to 2018 to obtain such information. The study also aimed to describe the demographics of the TIO population and the prognosis. The operational definition was based on hypophosphatemia or adult osteomalacia diagnoses, combined with prescriptions used in the initial management and procedures consistent with advanced imaging used for locating tumors. The incidence of TIO in Denmark was found to be below 0.13 per 100,000 person years for the total population of the country and 0.10 per 100,000 in adult-onset disease. The prevalence of TIO was estimated to be no more than 0.70 per 100,000 persons for the total population and 0.43 per 100,000 in adults. In 2018, there were a maximum of nine new cases of TIO in Danish adults. Mortality was low but few patients fulfilled the protocol cure criterion during the observation period. TIO has no ICD-10 code and limitations to the study include lack of information on serum biochemistry and on the use of phosphate supplements. Strengths include the use of long-term longitudinal, national hospital and prescription data from a country with universal healthcare. Given the very small patient population with TIO and the known delay to diagnosis and cure, management of patients with suspected TIO should be centralized
Evidence-based policy on dietary calcium and vitamin D
Copyright Š 2011 American Society for Bone and Mineral Research.Peer reviewedPostprin
Pauli Paramagnetic Effects on Vortices in Superconducting TmNi2B2C
The magnetic field distribution around the vortices in TmNi2B2C in the
paramagnetic phase was studied experimentally as well as theoretically. The
vortex form factor, measured by small-angle neutron scattering, is found to be
field independent up to 0.6 Hc2 followed by a sharp decrease at higher fields.
The data are fitted well by solutions to the Eilenberger equations when
paramagnetic effects due to the exchange interaction with the localized 4f Tm
moments are included. The induced paramagnetic moments around the vortex cores
act to maintain the field contrast probed by the form factor.Comment: 4 pages, 4 figure
Minimum Perimeter-Sum Partitions in the Plane
Let P be a set of n points in the plane. We consider the problem of partitioning P into two subsets P_1 and P_2 such that the sum of the perimeters of CH(P_1) and CH(P_2) is minimized, where CH(P_i) denotes the convex hull of P_i. The problem was first studied by Mitchell and Wynters in 1991 who gave an O(n^2) time algorithm. Despite considerable progress on related problems, no subquadratic time algorithm for this problem was found so far. We present an exact algorithm solving the problem in O(n log^4 n) time and a (1+e)-approximation algorithm running in O(n + 1/e^2 log^4(1/e)) time
Temperature Dependence of the Flux Line Lattice Transition into Square Symmetry in Superconducting LuNiBC
We have investigated the temperature dependence of the H || c flux line
lattice structural phase transition from square to hexagonal symmetry, in the
tetragonal superconductor LuNi_2B_2C (T_c = 16.6 K). At temperatures below 10 K
the transition onset field, H_2(T), is only weakly temperature dependent. Above
10 K, H_2(T) rises sharply, bending away from the upper critical field. This
contradicts theoretical predictions of H_2(T) merging with the upper critical
field, and suggests that just below the H_c2(T)-curve the flux line lattice
might be hexagonal.Comment: 4 pages, 3 figure
Integrated modelling of crop production and nitrate leaching with the Daisy model
An integrated modelling strategy was designed and applied to the Soil-Vegetation-Atmosphere Transfer model Daisy for simulation of crop production and nitrate leaching under pedo-climatic and agronomic environment different than that of model original parameterisation. The points of significance and caution in the strategy are: ⢠Model preparation should include field data in detail due to the high complexity of the soil and the crop processes simulated with process-based model, and should reflect the study objectives. Inclusion of interactions between parameters in a sensitivity analysis results in better account for impacts on outputs of measured variables. ⢠Model evaluation on several independent data sets increases robustness, at least on coarser time scales such as month or year. It produces a valuable platform for adaptation of the model to new crops or for the improvement of the existing parameters set. On daily time scale, validation for highly dynamic variables such as soil water transport remains challenging. ⢠Model application is demonstrated with relevance for scientists and regional managers. The integrated modelling strategy is applicable for other process-based models similar to Daisy. It is envisaged that the strategy establishes model capability as a useful research/decision-making, and it increases knowledge transferability, reproducibility and traceability
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