Acute Pyelonephritis management through Ayurveda - A Case Study

The role of Diet, Drugs and Medical attention is very important specially for Elderly People, most probably they were neglected because they need assistance. Modern Science enriched with Antibiotics which are not advisable for a long duration to Elderly, Diabetic & Immune compromised Patients. Even, in Elderly people the Organs are Fragile and most of the Drugs become contraindicated, in such condition Ayurveda is inevitable. Ayurveda explained Tryoupasthambha, Dinacharya, Rutucharya, Aaharaniyama and “Swasthasya Swasthya Rakshnaam Aaturasya Vikara Prsamanaam[1]” (prevention is better than cure) to preserve the health of healthy individual right from Childhood. Ayurveda plays a crucial role in promoting healthy Body and step forward in treating the disease based on Ayurvedic principles, where there is no role of antibiotics. Here is a case neglecting diet, physical activity and medical attention finally alighted to Diabetes, near prostate obstruction, upper urinary tract infection which agonized him severely. This condition according to Ayurveda~Vrukkavikara, Mutravaha Srotovikara, Vasti Vikara. All the protocols of Ayurveda Deepana, Paachna, Srotosodhana, Mutrala, Kapha Vatahara, Vata Anulomama, Pittasama Chikitsa, Krimihara Chikitsa Sutra are followed and treated with Chitrakadi Vati, Gokshuradi Kwatha, Diet, Physical exercise and Barley water

Retrospective study of long-term outcomes of enzyme replacement therapy in Fabry disease: Analysis of prognostic factors

Despite enzyme replacement therapy, disease progression is observed in patients with Fabry disease. Identification of factors that predict disease progression is needed to refine guidelines on initiation and cessation of enzyme replacement therapy. To study the association of potential biochemical and clinical prognostic factors with the disease course (clinical events, progression of cardiac and renal disease) we retrospectively evaluated 293 treated patients from three international centers of excellence. As expected, age, sex and phenotype were important predictors of event rate. Clinical events before enzyme replacement therapy, cardiac mass and eGFR at baseline predicted an increased event rate. eGFR was the most important predictor: hazard ratios increased from 2 at eGFR 90. In addition, men with classical disease and a baseline eGFR 60. Proteinuria was a further independent risk factor for decline in eGFR. Increased cardiac mass at baseline was associated with the most robust decrease in cardiac mass during treatment, while presence of cardiac fibrosis predicted a stronger increase in cardiac mass (3.36 gram/m2/year). Of other cardiovascular risk factors, hypertension significantly predicted the risk for clinical events. In conclusion, besides increasing age, male sex and classical phenotype, faster disease progression while on enzyme replacement therapy is predicted by renal function, proteinuria and to a lesser extent cardiac fibrosis and hypertension

Chromium(III) biosorption onto spent grains residual from brewing industry : equilibrium, kinetics and column studies

The use of industrial wastes for wastewater treatment as a strategy to their re-use and valorisation may provide important advances toward sustainability. The present work gives new insights into heavy metal biosorption onto low-cost biosorbents, studying chromium(III) biosorption onto spent grains residual from a Portuguese brewing industry both in batch and expanded bed column systems. Experimental studies involved unmodified spent grains and spent grains treated with NaOH. Metal uptake followed a rapid initial step, well described by the pseudo-second-order kinetic model up to 27 h, indicating chemisorption to be the rate-limiting step. Beyond this period intraparticle diffusion assumed an important role in the uptake global kinetics. The best fit for equilibrium data was obtained using the Langmuir model, with unmodified spent grains having the higher maximum uptake capacity (q max = 16.7 mg g1). In open system studies, using expanded bed columns, the best performance was also achieved with unmodified spent grains: Breakthrough time (C/C i = 0.25) and total saturation time (C/C i = 0.99) occurred after 58 and 199 h of operation, corresponding to the accumulation of 390 mg of chromium(III), 43.3 % of the total amount entering the column. These results suggest that alkali treatment does not improve spent grains uptake performance. Changes in biomass composition determined by Fourier transform infrared spectroscopy suggested hydroxyl groups and proteins to have an important role in chromium(III) biosorption. This study points out that unmodified spent grains can be successfully used as low-cost biosorbent for trivalent chromium.The authors would like to thank the Portuguese brewing industry UNICER for all the support and FCT (Fundacao para a Ciencia e a Tecnologia) financial support through the Grant PRAXIS XXI/BD/15945/98

Agalsidase alfa versus agalsidase beta for the treatment of Fabry disease: an international cohort study

BACKGROUND: Two recombinant enzymes (agalsidase alfa 0.2 mg/kg/every other week and agalsidase beta 1.0 mg/kg/every other week) have been registered for the treatment of Fabry disease (FD), at equal high costs. An independent international initiative compared clinical and biochemical outcomes of the two enzymes. METHODS: In this multicentre retrospective cohort study, clinical event rate, left ventricular mass index (LVMI), estimated glomerular filtration rate (eGFR), antibody formation and globotriaosylsphingosine (lysoGb3) levels were compared between patients with FD treated with agalsidase alfa and beta at their registered dose after correction for phenotype and sex. RESULTS: 387 patients (192 women) were included, 248 patients received agalsidase alfa. Mean age at start of enzyme replacement therapy was 46 (±15) years. Propensity score matched analysis revealed a similar event rate for both enzymes (HR 0.96, P=0.87). The decrease in plasma lysoGb3 was more robust following treatment with agalsidase beta, specifically in men with classical FD (β: -18 nmol/L, P<0.001), persisting in the presence of antibodies. The risk to develop antibodies was higher for patients treated with agalsidase beta (OR 2.8, P=0.04). LVMI decreased in a higher proportion following the first year of agalsidase beta treatment (OR 2.27, P=0.03), while eGFR slopes were similar. CONCLUSIONS: Treatment with agalsidase beta at higher dose compared with agalsidase alfa does not result in a difference in clinical events, which occurred especially in those with more advanced disease. A greater biochemical response, also in the presence of antibodies, and better reduction in left ventricular mass was observed with agalsidase beta

Znaczenie judeochrześcijańskich korzeni i świadectwa chrześcijan o korzeniach żydowskich dla integralnego zrozumienia przesłania biblijnego

Punktem wyjścia artykułu są pierwotne napięcia pomiędzy wyznawcami judaizmu i chrześcijaństwa. Autor na ich tle ukazuje historyczny przełom we wzajemnych relacjach judeochrześcijańskich, który nastąpił po Soborze Watykańskim II. Umożliwił on wkroczenie judaizmu i chrześcijaństwa w drogę braterstwa i dialogu. W przekonaniu autora było to możliwe za sprawą wysiłków papieży (tj. Jana Pawła II, Benedykta XVI i Franciszka) oraz wspólnych instytucji i organizacji chrześcijańsko-żydowskich. Autor podkreśla również, że relacje chrześcijańsko-żydowskie cechuje wzajemne poszanowanie przy jednoczesnym zachowaniu własnej tożsamości i wierności swojej tradycji religijnej i duchowej. Na zakończenie artykułu zostały przedstawione osobiste doświadczenia autora w dialogu chrześcijańsko-żydowskim

Znaczenie judeochrześcijańskich korzeni i świadectwa chrześcijan o korzeniach żydowskich dla integralnego zrozumienia przesłania biblijnego

The starting point for the article are the primary tensions between Jews and Christians. Against that background, the Author shows the historic breakthrough in Judeo-Christian relations that happened after the Second Vatican Council. It enabled Judaism and Christianity to enter the path of brotherhood and dialogue. According to the Author, this was possible due to the efforts made by the popes (i.e. John Paul II, Benedict XVI and Francis) and joint Christian-Jewish institutions and organizations. The Author also emphasizes that Christian-Jewish relations are characterizedby showing mutual respect while at the same time preserving their own identity and remaining faithful to their religious and spiritual tradition. The article ends with the presentation of the Author’s personal experience with the Christian-Jewish dialogue.Punktem wyjścia artykułu są pierwotne napięcia pomiędzy wyznawcami judaizmu i chrześcijaństwa. Autor na ich tle ukazuje historyczny przełom we wzajemnych relacjach judeochrześcijańskich, który nastąpił po Soborze Watykańskim II. Umożliwił on wkroczenie judaizmu i chrześcijaństwa w drogę braterstwa i dialogu. W przekonaniu autora było to możliwe za sprawą wysiłków papieży (tj. Jana Pawła II, Benedykta XVI i Franciszka) oraz wspólnych instytucji i organizacji chrześcijańsko-żydowskich. Autor podkreśla również, że relacje chrześcijańsko-żydowskie cechuje wzajemne poszanowanie przy jednoczesnym zachowaniu własnej tożsamości i wierności swojej tradycji religijnej i duchowej. Na zakończenie artykułu zostały przedstawione osobiste doświadczenia autora w dialogu chrześcijańsko-żydowskim

Are the streams of the Sinos River basin of good water quality? Aquatic macroinvertebrates may answer the question

Macroinvertebrate communities are one of the most used groups in assessments of water quality, since they respond directly to the level of contamination of aquatic ecosystems. The main objective of this study was the assessment of the water quality of the Sinos River basin (Rio Grande do Sul state, Brazil) through biotic indices based on the macroinvertebrate community ("Family Biotic Index - FBI", and "Biological Monitoring Working Party Score System - BMWP"). Three lower order streams (2nd order) were selected in each one of three main regions of the basin. In each stream, the samplings were performed in three reaches (upper, middle, and lower), totalling 27 reaches. Two samplings were carried in each reach over one year (winter and summer). A total of 6,847 macroinvertebrates distributed among 54 families were sampled. The streams from the upper region were of better water quality than the lower region. The water quality did not change between the upper, middle and lower reaches of the streams. However, the upper reaches of the streams were of better water quality in all the regions of the basin. The water quality of the streams did not vary between the summer and the winter. This result demonstrated that water quality may be analysed in both studied seasons (summer and winter) using biotic indices. The analysis of the results allows us to conclude that the biotic indices used reflected the changes related to the water quality along the longitudinal gradient of the basin. Thus, aquatic macroinvertebrates were important bioindicators of the water and environmental quality of the streams of the Sinos River basin.</jats:p

Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

Dihydropyrimidine dehydrogenase (DPD) is the initial enzyme acting in the catabolism of the widely used antineoplastic agent 5-fluorouracil (5FU). DPD deficiency is known to cause a potentially lethal toxicity following administration of 5FU. Here, we report novel genetic mechanisms underlying DPD deficiency in patients presenting with grade III/IV 5FU-associated toxicity. In one patient a genomic DPYD deletion of exons 21–23 was observed. In five patients a deep intronic mutation c.1129–5923C>G was identified creating a cryptic splice donor site. As a consequence, a 44 bp fragment corresponding to nucleotides c.1129–5967 to c.1129–5924 of intron 10 was inserted in the mature DPD mRNA. The deleterious c.1129–5923C>G mutation proved to be in cis with three intronic polymorphisms (c.483 + 18G>A, c.959–51T>G, c.680 + 139G>A) and the synonymous mutation c.1236G>A of a previously identified haplotype. Retrospective analysis of 203 cancer patients showed that the c.1129–5923C>G mutation was significantly enriched in patients with severe 5FU-associated toxicity (9.1%) compared to patients without toxicity (2.2%). In addition, a high prevalence was observed for the c.1129–5923C>G mutation in the normal Dutch (2.6%) and German (3.3%) population. Our study demonstrates that a genomic deletion affecting DPYD and a deep intronic mutation affecting pre-mRNA splicing can cause severe 5FU-associated toxicity. We conclude that screening for DPD deficiency should include a search for genomic rearrangements and aberrant splicing