Exploiting Properties of CMP Cache Traffic in Designing Hybrid Packet/Circuit Switched NoCs

Chip multiprocessors with few to tens of processing cores are already commercially available. Increased scaling of technology is making it feasible to integrate even more cores on a single chip. Providing the cores with fast access to data is vital to overall system performance. When a core requires access to a piece of data, the core's private cache memory is searched first. If a miss occurs, the data is looked up in the next level(s) of the memory hierarchy, where often one or more levels of cache are shared between two or more cores. Communication between the cores and the slices of the on-chip shared cache is carried through the network-on-chip(NoC). Interestingly, the cache and NoC mutually affect the operation of each other; communication over the NoC affects the access latency of cache data, while the cache organization generates the coherence and data messages, thus affecting the communication patterns and latency over the NoC. This thesis considers hybrid packet/circuit switched NoCs, i.e., packet switched NoCs enhanced with the ability to configure circuits. The communication and performance benefit that come from using circuits is predicated on amortizing the time cost incurred for configuring the circuits. To address this challenge, NoC designs are proposed that take advantage of properties of the cache traffic, namely temporal locality and predictability, to amortize or hide the circuit configuration time cost. First, a coarse-grained circuit configuration policy is proposed that exploits the temporal locality in the cache traffic to periodically configure circuits for the heavily communicating nodes. This allows the design of a locality-aware cache that promotes temporal communication locality through data placement, while designing suitable data replacement and migration policies. Next, a fine-grained configuration policy, called Déjà Vu switching, is proposed for leveraging predictability of data messages by initiating a circuit configuration as soon as a cache hit is detected and before the data becomes available. Its benefit is demonstrated for saving interconnect energy in multi-plane NoCs. Finally, a more proactive configuration policy is proposed for fast caches, where circuit reservations are initiated by request messages, which can greatly improve communication latency and system performance

The influence of customer integration, integrated information technology, and relationship commitment on performance: a mediating and moderating analysis in supply chain management context

Esta investigación amplía el creciente cuerpo de la literatura sobre la integración de la cadena de suministro. A partir de diferentes teorías, desarrollamos hipótesis que proponen relaciones positivas entre la tecnología de información integrada, la integración de clientes, el compromiso relacional y el rendimiento financiero. Además, investigamos los roles complementarios del tamaño del departamento de TI y el apoyo de la alta dirección. Los resultados a partir de una muestra de 205 empresas de Egipto indican que la tecnología de información integrada y la integración de clientes pueden mejorar el rendimiento financiero. Adicionalmente, los resultados muestran un efecto mediador positivo de la integración de clientes en la relación entre tecnología de información integrada y el rendimiento financiero. Además, se confirma que el tamaño del departamento de TI y el apoyo de la alta dirección están relacionados significativamente con la tecnología de información integrada. Finalmente, nuestros resultados también muestran un efecto positivo directo del compromiso relacional en la integración de clientes, así como un efecto moderador positivo del compromiso relacional en la relación entre la tecnología de información integrada y la integración de clientes.This research extends the developing body of literature on supply chain integration. Theorizing from the supply chain integration literatures, we develop hypotheses proposing direct, mediating, and moderating relations between integrated information technology, customer integration, relationship commitment, and financial performance. Also, we investigate the complementary roles of IT department size and top management support. Our findings from a sample of 205 firms in Egypt indicate that integrated information technology and customer integration can improve financial performance. In addition, our results show a mediating and positive effect of customer integration on the relation between integrated information technology and financial performance. Also, information technology department size and top management support are significantly related to integrated information technology. Finally, our results also show a direct and positive effect of relationship commitment on the customer integration, and a moderating and positive effect of relationship commitment on the relationship between integrated information technology and customer integration

An Experimental Comparison of Speed Scaling Algorithms with Deadline Feasibility Constraints

We consider the first, and most well studied, speed scaling problem in the algorithmic literature: where the scheduling quality of service measure is a deadline feasibility constraint, and where the power objective is to minimize the total energy used. Four online algorithms for this problem have been proposed in the algorithmic literature. Based on the best upper bound that can be proved on the competitive ratio, the ranking of the online algorithms from best to worst is: $qOA$, $OA$, $AVR$, $BKP$. As a test case on the effectiveness of competitive analysis to predict the best online algorithm, we report on an experimental ``horse race\u27\u27 between these algorithms using instances based on web server traces. Our main conclusion is that the ranking of our algorithms based on their performance in our experiments is identical to the order predicted by competitive analysis. This ranking holds over a large range of possible power functions, and even if the power objective is temperature

Distinct cytokine patterns in Occult Hepatitis C and Chronic Hepatitis C Virus Infection

Background & Aim: 
The immunopathogenesis of chronic hepatitis C virus (HCV) infection is a matter of great controversy. The imbalance of T-helper lymphocyte cell cytokine production was believed to play an important pathogenic role in chronic viral hepatitis. Occult hepatitis C infection is regarded as a new entity that should be considered when diagnosing patients with a liver disease of unknown origin. The aim of this study was to determine serum T-helper 1 and T-helper 2 cytokine production in patients with occult HCV infection and its role in pathogenesis versus chronic viral hepatitis C infection.

Methods: 
Serum levels of cytokines of T-helper 1 (IL-2, IFN-[gamma]) and T-helper 2 (IL-4) were measured in 27 patients with occult HCV infection and 50 patients with chronic hepatitis C infection.

Results: 
The levels of the T-helper 1 cytokines, IL-2 and IFN-[gamma], were highly and significantly increased in patients with chronic HCV infection as compared with occult HCV infection (p<0.001). The T-helper 2 cytokine IL-4 was highly and significantly increased in occult HCV infection as compared with chronic HCV infection (p<0.001). Necroinflammation (P<0.001) fibrosis (P<0.001) and cirrhosis (P =0.03) were significantly increased in chronic HCV than occult HCV. 

Conclusion: 
Patients with occult HCV infection exhibited distinct immunoregulatory cytokine patterns, favoring viral persistence in the liver in spite of its absence from peripheral blood and explaining the less aggressive course of this disease entity than chronic hepatitis C virus infection

SOLID LIPID NANOPARTICLES AND NANOSTRUCTURED LIPID CARRIERS OF TOLNAFTATE: DESIGN, OPTIMIZATION AND IN-VITRO EVALUATION

Objective: The target of our work is the preparation of tolnaftate (TOL) loaded solid lipid nanoparticles (SLNs) as well as nanostructured lipid carriers (NLCs).Methods: The high shear homogenization method was chosen for the preparation of nanoparticles. The nanoparticle dispersions were prepared using Compritol 888ATO, Tefose 63, Miglyol® 812, Poloxamer188, and Tween80. Particle size (PS), zeta potential (ZP), polydispersity index (PDI), drug entrapment efficiency (EE) and in vitro release study were determined. Differential Scanning Calorimetry (DSC) analysis and morphological transmission electron microscopy (TEM) examination were conducted. A stability study for 3 mo was performed.Results: The results revealed that NLC and SLN dispersions had spherical shapes with an average size between 41.10±1.92 nm and 98.85±1.01 nm. High entrapment efficiency was obtained with negatively charged zeta potential with PDI value ranging from 0.251±0.012 to 0.759±0.028. The release profiles of all formulations were characterized by a sustained release behavior over 24 h and the release rates increased as the amount of liquid lipid in lipid core increased. Tolnaftate loaded NLC showed more stability than its corresponding SLN.Conclusion: It can be fulfilled from this work that NLCs may represent a promising carrier for tolnaftate delivery offering both sustained release and stability.Â

EFFECT OF METHYL-Î’-CYCLODEXTRIN COMPLEXATION ON THE HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF KHELLIN: EXPERIMENTAL STUDY

Objective: The present work tackled the development and evaluation of inclusion complex of khellin (KH) and methyl-β-cyclodextrin (MβCD). In addition, it tested its possible hypoglycemic and hypolipidemic effects.Methods: Inclusion complexes of KH-MβCD in the presence of water-soluble polymer were prepared by freeze drying (FD), co-evaporation (EV) and kneading methods (KN). The selected ternary complex was characterized by Fourier transform infrared spectrophotometry (FTIR), x-ray diffractometry (XRD), differential scanning calorimetry (DSC) and scanning electron microscopy [1]. Assessment of the hypoglycemic effect of the selected ternary complex versus the standard drug metformin was studied. Two different doses of the ternary complex were administered orally to streptozotocin (STZ)-induced type 2diabetic rats. Their hypoglycemic and hypolipidemic effects were evaluated by measuring the fasting blood glucose level (BGL), total cholesterol (TC) and triglycerides levels (TG) along the study period.Results: The FD complex showed the highest drug dissolution rate. All the performed characterization analysis confirmed the formation of a KH-MβCD inclusion complex. The in vivo study declared that both doses showed a marked hypoglycemic and hypolipidemic effects compared to metformin.Conclusion: In conclusion, this study points for the first time that the complexation of KH with MβCD could notably improve the dissolution rate and hence the bioavailability of KH. Moreover, this study demonstrated that this compound has a hypoglycemic and hypolipidemic effect. Thus, it can be a promising natural supportive treatment in type 2 diabetes mellitus (T2DM).Â

Topology-Guided Multi-Class Cell Context Generation for Digital Pathology

In digital pathology, the spatial context of cells is important for cell classification, cancer diagnosis and prognosis. To model such complex cell context, however, is challenging. Cells form different mixtures, lineages, clusters and holes. To model such structural patterns in a learnable fashion, we introduce several mathematical tools from spatial statistics and topological data analysis. We incorporate such structural descriptors into a deep generative model as both conditional inputs and a differentiable loss. This way, we are able to generate high quality multi-class cell layouts for the first time. We show that the topology-rich cell layouts can be used for data augmentation and improve the performance of downstream tasks such as cell classification.Comment: To be published in proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) 202

Nanolipogel Loaded with Tea Tree Oil for the Management of Burn: GC-MS Analysis, In Vitro and In Vivo Evaluation

The GC-MS analysis of tea tree oil (TTO) revealed 38 volatile components with sesquiterpene hydrocarbons (43.56%) and alcohols (41.03%) as major detected classes. TTO efficacy is masked by its hydrophobicity; nanoencapsulation can address this drawback. The results showed that TTO-loaded solid lipid nanoparticles (SLN1), composed of glyceryl monostearate (2% w/w) and Poloxamer188 (5% w/w), was spherical in shape with a core-shell microstructure. TTO-SLN1 showed a high entrapment efficiency (96.26 ± 2.3%), small particle size (235.0 ± 20.4 nm), low polydispersity index (0.31 ± 0.01), and high negative Zeta potential (−32 mV). Moreover, it exhibited a faster active agent release (almost complete within 4 h) compared to other formulated TTO-SLNs as well as the plain oil. TTO-SLN1 was then incorporated into cellulose nanofibers gel, isolated from sugarcane bagasse, to form the ‘TTO-loaded nanolipogel’ which had a shear-thinning behavior. Second-degree thermal injuries were induced in Wistar rats, then the burned skin areas were treated daily for 7 days with the TTO-loaded nanolipogel compared to the unmedicated nanolipogel, the TTO-loaded conventional gel, and the normal saline (control). The measurement of burn contraction proved that TTO-loaded nanolipogel exhibited a significantly accelerated skin healing, this was confirmed by histopathological examination as well as quantitative assessment of inflammatory infiltrate. This study highlighted the success of the proposed nanotechnology approach in improving the efficacy of TTO used for the repair of skin damage induced by burns