Adsorption and inhibitive properties of methanol extract of Eeuphorbia Heterophylla for the corrosion of copper in 0.5 M nitric acid solutions

The adsorption and the inhibitive properties of methanol extract of Euphorbia heterophylla on copper in 0.5 M HNO3 have been studied by weight loss method at different temperatures (30-50°C), potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and electrochemical frequency modulation (EFM) techniques. Also, the surface morphology was analyzed by scanning electron microscopy (SEM). It was found that the inhibition efficiency increases with increasing extract doses and decreased with increasing temperature. The polarization data revealed that this extract acts as mixed type inhibitor. The adsorption process was more favored at lower temperatures with larger negative standard free energy. The extract was adsorbed physically on the copper surface followed Frumkin isotherm

Adsorption and inhibitive properties of methanol extract of Eeuphorbia Heterophylla for the corrosion of copper in 0.5 M nitric acid solutions

The adsorption and the inhibitive properties of methanol extract of Euphorbia heterophylla on copper in 0.5 M HNO3  have been studied by weight loss method at different temperatures (30-50°C), potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and electrochemical frequency modulation (EFM) techniques. Also, the surface morphology was analyzed by scanning electron microscopy (SEM). It was found that the inhibition efficiency increases with increasing extract doses and decreased with increasing temperature. The polarization data revealed that this extract acts as mixed type inhibitor. The adsorption process was more favored at lower temperatures with larger negative standard free energy. The extract was adsorbed physically on the copper surface followed Frumkin isotherm

Dodecanoyl thiosemicarbazide derivatives as useful synthons in the synthesis of 1,2,4-triazole, 1,3,4-thiadiazole, and 1,3-benzothiazole derivatives

<p>A convenient synthesis of the dodecanoyl thiosemicarbazide derivatives <b>3a, b</b> has been achieved from the reaction of 2-benzamido-3-arylacryloylhydrazides <b>1a, b</b> and lauroyl isothiocyanate <b>(2)</b>. The thiosemicarbazide derivative <b>3a</b> is used as precursor for synthesis of 1,2,4-triazole, 1,3,4-thiadiazole, and 1,3-benzothiazole derivatives. The antimicrobial activity of some of the synthesized compounds was tested.</p

Novel pyrano[2,3-c]pyrazolopyrimidines as promising anticancer agents: Design, synthesis, and cell cycle arrest of HepG2 cells at S phase

The poor selectivity, significant toxicity, high cost, and emergence of resistance of conventional chemotherapies are driving motive for the ongoing search for novel anticancer agents. New pyrano[2,3-c]pyrazolopyrimidines were synthesized and examined as antiproliferative agents, and the possible molecular mechanism(s) of action were explored. The mass and elemental analyses, alongside the IR,1H, and 13C NMR spectra, confirmed the proposed structures of the obtained compounds. Derivatives 4 and 7 demonstrated the best antiproliferative profile against HepG2 cancer cells at 4 µM, with a high selectivity index of ∼7–9 folds. They increased the S phase cell population by 51% and 40% and caused a 5- and 11-fold increase in the p21 protein. Compound 7 was superior in inhibiting HepG2 cell migration and delayed wound healing, reducing migration rates by 55% and 90%, respectively. Future studies on the pharmacokinetics, pharmacodynamics, antimetastatic, and antitumor activities in animal models would be a robust advance.</p