Dodecanoyl thiosemicarbazide derivatives as useful synthons in the synthesis of 1,2,4-triazole, 1,3,4-thiadiazole, and 1,3-benzothiazole derivatives

Abstract

<p>A convenient synthesis of the dodecanoyl thiosemicarbazide derivatives <b>3a, b</b> has been achieved from the reaction of 2-benzamido-3-arylacryloylhydrazides <b>1a, b</b> and lauroyl isothiocyanate <b>(2)</b>. The thiosemicarbazide derivative <b>3a</b> is used as precursor for synthesis of 1,2,4-triazole, 1,3,4-thiadiazole, and 1,3-benzothiazole derivatives. The antimicrobial activity of some of the synthesized compounds was tested.</p