أثر تتبع سلسلة التوريد باستخدام تقنية نظام التموضع العالمي على الميزة التنافسية في شركات صناعة الأغذية الأردنية

هدفت المقال إلى بيان أثر تتبع سلسلة التوريد باستخدام تقنية نظام التموضع العالمي على الميزة التنافسية في شركات صناعة الأغذية الأردنية. تعتبر هذه الدراسة وصفية وسببية، وقد تم استخدام الاستبانة لجمع البيانات والتي تم تطويرها لهذا الغرض بناء على الدراسات السابقة وبمساعدة لجنة التحكيم. تم استهداف جميع شركات الأغذية المسجلة في غرفة صناعة الأردن والتي تستخدم تقنية نظام التموضع العالمي وعددها 28 شركة، وهذا يلغي الحاجة لاختيار عينة. تم استرجاع 134 استبانة من أصل 180 استبانة تم توزيعها، وكانت جميعها صالحة للتحليل، وبعد ان تم التأكد من التوزيع الطبيعي، الصدق، الثبات، الارتباط، تم استخدام تحليل الانحدار المتعدد لفحص الفرضيات. وأظهرت النتائج ان هناك تطبيق متوسط لتتبع سلسلة التوريد بتقنية (GPS) بأبعادها (تتبع الموردين، تتبع الداخلي، تتبع الزبائن) وان هناك مستوى تطبيق متوسط للميزة التنافسية بأبعادها (الجودة، التكلفة، المرونة، السرعة)، واظهرت النتائج ان هناك علاقة بين أبعاد تتبع سلسلة التوريد باستخدام تقنية (GPS) وأبعاد الميزة التنافسية. وأخيرا هناك أثر لتتبع سلسلة التوريد باستخدام تقنية (GPS) على الميزة التنافسية، حيث كان الأثر الأكبر للتتبع الداخلي ثم تتبع الزبائن، أخيرا كان هناك أثر سلبي لتتبع الموردين على الميزة التنافسية. توصي الدراسة شركات صناعة الأغذية الأردنية بتطبيق تتبع سلسلة التوريد بتقنية (GPS) بعناصرها مجتمعه بشكل أفضل لأنها تؤثر على بعضها البعض، كما توصي باستخدام أكبر لتتبع الموردين

The Arts of Arabization and Islamization in the light of Globalization

This research aims at urging Muslim and Arab scientists, scholars and artists to study insightfully other coming cultures, refining them and taking all that help in building. renewing and allows opportunities of communication for a civilization that dates back to more than 15 centuries which guarantee its persistence and sustainability with all the the arts it includes. Many of us may only perceive the bright aspects of other cultures unaware of the importance of maintaining our Arab and Muslim identity targeted mischievously by many others where our efforts of protecting this civilization is now the most urgently needed particularly and the prevalence of globalization bridging gaps among civilizations and the emergence of technology. This research also aims at clarifying the extent to which European arts are influenced by all the Islamic arts including architecture, mosaic and other different art In fact. this make another strong proof of the importance Islamic cultures occupies among world civilizations

The Arts of Arabization and Islamization in the light of Globalization

This research aims at urging Muslim and Arab scientists. scholars and artists to study insightfully other coming cultures, refining them and taking all that help in building. renewing and allows opportunities of communication for a civilization that dates back to more than 15 centuries which guarantee its persistence and sustainability with all the 3113 it includes, Many of us may only perceive the bright aspects of other cultures unaware of the importance of maintaining our Arab and Muslim identity targeted mischievously by many others where our efforts of protecting this civilization is now the most urgently needed particularly and the prevalence of globalization bridging gaps among civilizations and the emergence of technology. This research also aims at clarifying the extent to which European arts are influenced by all the Islamic arts including amhitccturc‘ mosaic and other different art In fact. this make another strong proof of the importance Islamic cultures occupies among world civilizations

Micrornas 33, 122, And 208: A Potential Novel Targets In The Treatment Of Obesity, Diabetes, And Heart-Related Diseases

Despite decades of research, obesity and diabetes remain major health problems in the USA and worldwide. Among the many complications associated with diabetes is an increased risk of cardiovascular diseases, including myocardial infarction and heart failure. Recently, microRNAs have emerged as important players in heart disease and energy regulation. However, little work has investigated the role of microRNAs in cardiac energy regulation. Both human and animal studies have reported a significant increase in circulating free fatty acids and triacylglycerol, increased cardiac reliance on fatty acid oxidation, and subsequent decrease in glucose oxidation which all contributes to insulin resistance and lipotoxicity seen in obesity and diabetes. Importantly, MED13 was initially identified as a negative regulator of lipid accumulation in Drosophilia. Various metabolic genes were downregulated in MED13 transgenic heart, including sterol regulatory element-binding protein. Moreover, miR-33 and miR-122 have recently revealed as key regulators of lipid metabolism. In this review, we will focus on the role of microRNAs in regulation of cardiac and total body energy metabolism. We will also discuss the pharmacological and non-pharmacological interventions that target microRNAs for the treatment of obesity and diabetes

Synergistic Beneficial Effects of Resveratrol and Diet on High-Fat Diet-Induced Obesity

Introduction: Despite decades of research, obesity and its related medical complications remain a major health concern globally. Therefore, novel therapeutic strategies are needed to combat obesity and its numerous debilitating complications. Resveratrol (RES) has a potential therapeutic effect in obesity and diabetes by improving oxidative metabolism and insulin signaling. Background and Objectives: The aim of this study was to investigate the effect of RES treatment on weight loss and glucose and fatty acid metabolism. Methods: Obesity was induced in 24 mice by exposure to a high-fat diet (HFD) for 8 weeks. Mice were randomly assigned to one group of either: group 1: control, non-treated low-fat diet (LFD) for 12 weeks (n = 8), group 2: non-treated high-fat diet (HFD) for 12 weeks (n = 8), group 3: RES-treated HFD (HFD + RES) (n = 8), or group 4: RES-treated and switched to LFD (HFD-LFD + RES) (n = 8). HFD + RES mice were first fed an HFD for 8 weeks followed by 4 weeks of RES. The HFD-LFD + RES group was first fed an HFD for 8 weeks and then treated with RES and switched to an LFD for 4 weeks. Results: After 12 weeks, group 2 mice had significantly higher body weights compared to group 1 (23.71 ± 1.95 vs. 47.83 ± 2.27; p < 0.05). Group 4 had a significant decrease in body weight and improvement in glucose tolerance compared to mice in group 2 (71.3 ± 1.17 vs. 46.1 ± 1.82 and 40.9 ± 1.75, respectively; p < 0.05). Skeletal muscles expression of SIRT1, SIRT3, and PGC1α were induced in group 3 and 4 mice compared to group 2 (p < 0.01), with no changes in AMP-activated protein kinase expression levels. Furthermore, combination of RES and diet ameliorated skeletal muscle intermediate lipid accumulation and significantly improved insulin sensitivity and secretion. Conclusions: The results of this study suggest a synergistic beneficial effect of LFD and RES to lower body weight and enhance glucose and fatty acid metabolism

Obesity Paradox among Heart Failure with Reduced Ejection Fraction Patients: A Retrospective Cohort Study

Background and Objectives: There is consensus on the negative effects of obesity on the development of heart failure. However, several studies have suggested that obesity may have paradoxical survival benefits in heart failure patients. Therefore, the aim of this study is to investigate whether the obesity paradox exists in heart failure with reduced ejection fraction (HFrEF) patients in Jordan. Materials and Methods: In this retrospective cohort study, data were retrieved from electronic hospital records of heart failure patients admitted to King Abdullah University Hospital between January 2010 and January 2020. Patients were divided into five BMI (kg/m2) subgroups: (1) Less than 25.0, (2) Overweight 25.0–29.9, (3) Obese Class I 30.0–34.9, (4) Obese Class II 35.0–39.9, and (5) Obese Class III ≥40.0. Changes in patients’ clinical and echocardiographic parameters over one year were analyzed. Results: Data of a total of 297 patients were analyzed to determine the effect of obesity on heart failure. The mean age was 64.6 ± 12.4 years, and most patients (65.7%) were male. Among several co-morbidities, diabetes mellitus and hypertension were the most common and were present in 81.8% and 81.1% of patients, respectively. Over all patients, there was no significant change in EF after 1 year compared to baseline. However, only patients in the Obese Class I group had a statistically significant improvement in EF of 38.0 ± 9.81% vs. 34.8 ± 6.35% (p = 0.004) after 1 year. Importantly, among non-diabetic individuals, only Obese Class I patients had a significant (p p Conclusions: Our study demonstrates an inverted U-shaped relationship between BMI and EF such that patients with mild obesity (i.e., Obese Class I) had significant improvement in EF compared to those having a lower and higher BMI. We, therefore, suggest the existence of the obesity paradox among HFrEF patients in Jordan

The Effect of Long-Term Second-Generation Antipsychotics Use on the Metabolic Syndrome Parameters in Jordanian Population

Objectives: The aim of this study was to determine the incidence of metabolic syndrome in patients treated with second-generation antipsychotics (SGAs). Methods: In this retrospective study, we reviewed patients’ electronic medical records (EMRs) of all patients who received one SGA for at least six months, excluding patients who were taking other medications that are associated with significant effect on metabolic syndrome. Relevant clinical information was collected prior to starting the SGA and after six months of continuous use of the same SGA. Results: A total of 91 patients were included in the study. The majority of patients (72%) were diagnosed with schizophrenia. After six months of taking the SGA, 44% of patients experienced elevated systolic pressure, 54.9% had elevated triglyceride, and 31.9% had impaired glucose levels (p value < 0.05). Prior to initiating SGA therapy, 14.3% of patients had metabolic syndrome, while 37.4% had metabolic syndrome after six months of therapy, and it was more prominent in males compared to female patients (p value < 0.05). Conclusion: This study found a strong correlation between SGA use and the appearance of metabolic alterations, such as weight gain, glucose intolerance, and increased triglyceride levels. These findings highlight the importance of assessing metabolic deregulations to minimize SGA associated metabolic abnormalities

Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide

The study of intercellular adhesion molecule-1 (ICAM-1) and SIRT1, a member of the sirtuin family with nitric oxide (NO), is emerging in depression and anxiety. As with all antidepressants, the efficacy is delayed and inconsistent. Ascorbic acid (AA) and vitamin D (D) showed antidepressant properties, while etifoxine (Etx), a GABAA agonist, alleviates anxiety symptoms. The present study aimed to investigate the potential augmentation of citalopram using AA, D and Etx and related the antidepressant effect to brain and serum ICAM-1, SIRT1 and NO in an animal model. BALB/c mice were divided into naive, control, citalopram, citalopram + etx, citalopram + AA, citalopram + D and citalopram + etx + AA + D for 7 days. On the 8th day, the mice were restrained for 8 h, followed by a forced swim test and marble burying test before scarification. Whole-brain and serum expression of ICAM-1, Sirt1 and NO were determined. Citalopram’s antidepressant and sedative effects were potentiated by ascorbic acid, vitamin D and etifoxine alone and in combination (p p p p < 0.05) versus naive. Both ICAM-1 and Sirt1 were modulated by antidepressants through a non-NO-dependent pathway. Serum NO expression was unrelated to serum ICAM-1 and Sirt1. Brain ICAM-1, Sirt1 and NO are implicated in depression and are modulated by antidepressants

Chemical composition, anticancer, antimicrobial activity of Aloysia citriodora Palau essential oils from four different locations in Palestine

Abstract The primary aim of this investigation was to determine the anticancer and antimicrobial properties of essential oils (EOs) extracted from the leaves of Aloysia citriodora Palau, which were procured from four separate locations in Palestine, in addition to analyzing their chemical composition. These areas include Jericho, which has the distinction of being the lowest location on Earth, at 260 m below sea level. The EOs were acquired by hydrodistillation, and their chemical composition was examined utilizing gas chromatography-mass spectrometry (GC-MS). The minimum inhibitory concentration (MIC) of EOs was assessed against six bacterial strains and one fungal species using 96-well microtiter plates. The primary components found in these oils are geranial (26.32–37.22%), neral (18.38–29.00%), and α-curcumene (7.76–16.91%) in three regions. α-Curcumene (26.94%), spathulenol (13.69%), geranial (10.79%), caryophyllene oxide (8.66%), and neral (7.59%) were found to be the most common of the 32 chemical components in the EO from Jericho. The EOs exhibited bactericidal properties, particularly against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and showed highly effective fungicidal activity. Nevertheless, the antifungal efficacy of the EO was found to surpass its antibacterial activity when administered at lower dosages. The EOs exhibited anticancer activities against melanoma cancer cells, as indicated by their IC50 values, which ranged from 4.65 to 7.96 μg/mL. A. citriodora EO possesses substantial antifungal and anticancer characteristics, rendering it appropriate for utilization in food-related contexts, hence potentially enhancing the sustainability of the food sector