atrophy plus syndrome, or costeff optic atrophy syndrome): identification of the OPA3 gene and its

deficiencies in a male with cardiomyopathy and 3-methylglutaconic aciduria, ” J Inherit Metab Dis

Psychosocial impact of alternative management policies for low-grade cervical abnormalities : results from the TOMBOLA randomised controlled trial

Background: Large numbers of women who participate in cervical screening require follow-up for minor cytological abnormalities. Little is known about the psychological consequences of alternative management policies for these women. We compared, over 30-months, psychosocial outcomes of two policies: cytological surveillance (repeat cervical cytology tests in primary care) and a hospital-based colposcopy examination. Methods: Women attending for a routine cytology test within the UK NHS Cervical Screening Programmes were eligible to participate. 3399 women, aged 20–59 years, with low-grade abnormal cytology, were randomised to cytological surveillance (six-monthly tests; n = 1703) or initial colposcopy with biopsies and/or subsequent treatment based on colposcopic and histological findings (n = 1696). At 12, 18, 24 and 30-months post-recruitment, women completed the Hospital Anxiety and Depression Scale (HADS). A subgroup (n = 2354) completed the Impact of Event Scale (IES) six weeks after the colposcopy episode or first surveillance cytology test. Primary outcomes were percentages over the entire follow-up period of significant depression (≥8) and significant anxiety (≥11; “30-month percentages”). Secondary outcomes were point prevalences of significant depression, significant anxiety and procedure-related distress (≥9). Outcomes were compared between arms by calculating fully-adjusted odds ratios (ORs) for initial colposcopy versus cytological surveillance. Results: There was no significant difference in 30-month percentages of significant depression (OR = 0.99, 95% CI 0.80–1.21) or anxiety (OR = 0.97, 95% CI 0.81–1.16) between arms. At the six-week assessment, anxiety and distress, but not depression, were significantly less common in the initial colposcopy arm (anxiety: 7.9% vs 13.4%; OR = 0.55, 95% CI 0.38–0.81; distress: 30.6% vs 39.3%, OR = 0.67 95% CI 0.54–0.84). Neither anxiety nor depression differed between arms at subsequent time-points. Conclusions: There was no difference in the longer-term psychosocial impact of management policies based on cytological surveillance or initial colposcopy. Policy-makers, clinicians, and women themselves can be reassured that neither management policy has a significantly greater psychosocial cost

Biopsy and selective recall compared with immediate large loop excision in management of women with low grade abnormal cervical cytology referred for colposcopy : multicentre randomised controlled trial

Peer reviewedPublisher PD

ANALISIS PERBANDINGAN RETURN, ABNORMAL RETURN DAN VOLUME PERDAGANGAN SAHAM SEBELUM DAN SESUDAH PERISTIWA JANUARY EFFECT PADA PERUSAHAAN DI INDEKS IDX 30 PERIODE 2019-2021

ABSTRAK ANALISIS PERBANDINGAN RETURN, ABNORMAL RETURN DAN VOLUME PERDAGANGAN SAHAM SEBELUM DAN SESUDAH PERISTIWA JANUARY EFFECT PADA PERUSAHAAN DI INDEKS IDX 30 PERIODE 2019-2021 FITRI DINDA MULYANI 11870121698 Penelitian terkait fenomena January effect berguna agar investor dapat memperoleh return yang lebih tinggi pada bulan January. Penelitian dilakukan pada perusahaan di Indeks IDX 30 yang bertujuan untuk mengetahui perbedaan return, abnormal return dan volume perdagangan saham sebelum dan sesudah January effect pada perusahaan di indeks IDX 30 yang terdaftar di Bursa Efek Indonesia periode 2019-2021. Analisis yang digunakan untuk menguji hipotesis penelitian ini adalah analisis kuantitatif dengan metode statistik uji normalitas dan uji wilcoxon test. Hasil penelitian menunjukkan bahwa : (1) Terdapat perbedaan return yang signifikan sebelum dan sesudah January effect pada 18 perusahaan sampel di IDX 30 periode 2019-2021 dengan nilai signifikansi sebesar 0,001 atau berada dibawah tingkat signifikansi 0,005. (2) Tidak terdapat perbedaan abnormal return yang signifikan sebelum dan sesudah January effect pada 18 perusahaan sampel di IDX 30 periode 2019-2021 dengan nilai signifikansi sebesar 0,270 atau berada diatas tingkat signifikansi 0,005. (3) Tidak terdapat perbedaan volume perdagangan saham yang signifikan sebelum dan sesudah January effect pada 18 perusahaan sampel di IDX 30 periode 2019-2021 dengan nilai signifikansi sebesar 0,780 atau berada diatas tingkat signifikansi 0,005. Kata Kunci : January Effect, Return, Abnormal Return dan Volume Perdagangan Saha