Inappropriate ICD Discharge Related to Electrical Muscle Stimulation in Chiropractic Therapy: A Case Report

<p><b>Article full text</b></p> <p><br></p> <p>The full text of this article can be found here<b>. </b><a href="https://link.springer.com/article/10.1007/s40119-017-0086-6">https://link.springer.com/article/10.1007/s40119-017-0086-6</a></p><p></p> <p><br></p> <p><b>Provide enhanced content for this article</b></p> <p><br></p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p><br></p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p><br></p> <p>Other enhanced features include, but are not limited to:</p> <p><br></p> <p>• Slide decks</p> <p>• Videos and animations</p> <p>• Audio abstracts</p> <p>• Audio slides</p

Additional file 1: of Trade in medicines and the public's health: a time series analysis of import disruptions during the 2015 India-Nepal border blockade

Time-series analyses of trade in health commodities, 2011-2016. (PDF 801 kb

Effective <i>Agrobacterium</i>-mediated genetic transformation of okra (<i>Abelmoschus esculentus</i> L.) and generation of RNAi plants resistant to <i>Begomovirus</i> infecting okra

Okra is an important vegetable crop of the Malvaceae family and is infected by varying numbers of viruses of the genus Begomovirus. Regardless of the importance of the crop, very little consideration has been given to its genetic improvement. RNA interference (RNAi), a potent biotechnological tool, is known to control Begomovirus in many crops. For the implementation of successful RNAi, there is a need for an efficient genetic transformation system in okra. In the present study, we developed a procedure for Agrobacterium-mediated tissue culture–dependent regeneration of okra plants for the application of RNAi. Eleven transgenic okra RNAi plants were regenerated by utilising hypocotyls as explants. Transformed plants were screened with hygromycin at the regeneration stage and the presence of transgenes (AC1, AC2 & AC4 codes for replication-associated protein, transcriptional activator protein and suppressor of PTGS) in putative transformed plants was confirmed by polymerase chain reaction (PCR). Wild and transgenic lines were challenged with a dimeric Begomovirus clone or viruliferous whiteflies and the level of resistance was estimated with quantitative real-time reverse transcriptase PCR (qRT-PCR) by utilising viral gene–specific primers. The resistant transgenic lines accumulated very low titres of viral gene products according to the qRT-PCR assays compared to the control plants. This is the first report of tissue culture–mediated RNAi-derived resistance in okra against Begomovirus infection.</p

Additional file 2: of Trade in medicines and the public's health: a time series analysis of import disruptions during the 2015 India-Nepal border blockade

Residual calculation for penicillin and streptomycin exports. (XLSX 54 kb

Methane Adsorption and Separation in Slipped and Functionalized Covalent Organic Frameworks

Understanding atomic-level mechanisms of methane adsorption in nanoporous materials is of great importance to increase their methane storage capacity targeting energy sources with low carbon emission. In this work, we considered layered covalent organic frameworks (COFs) with low density and revealed the effect of slipping and chemical functionalization on their methane adsorption and separation properties. We performed grand canonical Monte Carlo simulations studies of methane (CH₄) adsorption and carbon-dioxide:methane (CO₂:CH₄) separation in various slipped structures of TpPa1, TpBD, PI-COFs, and functionalized TpPa1 and TpBD COFs as well. We observed that the slipping improves the total CH₄ uptake by 1.1–1.5 times, while functionalization does not have a significant effect on CH₄ uptake. We also observed improvement in CO₂:CH₄ selectivity due to slipping, whereas functionalization results in decrease in the selectivity. In all considered COFs, we found the highest CH₄ delivery capacity of 141 cm³ (STP) cm^–3 at 65 bar and selectivity of ∼25 at 1 bar in 60-AB slipped structure of TpBD COF. We analyzed the molecular details of CH₄ adsorption using binding energy, heat of adsorption, pore characteristics, and expectation energy landscape. Our results show that COFs with increasing profile of heat of adsorption with pressure have the higher CH₄ delivery capacity. In these COFs, we found proximity (∼4–6 Å) of CH₄ binding sites, resulting in higher CH₄–CH₄ interactions and hence the increasing profile of CH₄ heat of adsorption

Direct Heteroarylation of Tautomerizable Heterocycles into Unsymmetrical and Symmetrical Biheterocycles via Pd/Cu-Catalyzed Phosphonium Coupling

The direct cross-coupling of tautomerizable heterocycles with various unfunctionalized heteroarenes has been achieved through PyBroP-mediated and Pd/Cu-catalyzed sequential C–OH/C–H activation. The methodology allows a facile entry into novel diazine-azole biheterocyclic frameworks. Moreover, an unprecedented Pd-catalyzed phosphonium homocoupling of tautomerizable heterocycles was also developed to afford a direct synthetic route to symmetrical 1,2-, 1,3-, and 1,4-bidiazine units

Synthesis of Plantazolicin Analogues Enables Dissection of Ligand Binding Interactions of a Highly Selective Methyltransferase

A convergent strategy for the synthesis of truncated analogues of plantazolicin (PZN), a member of the thiazole/oxazole-modified microcin (TOMM) class of natural products, has been developed. These <i>N</i>-terminal mono-, tri-, and pentazole substructures of PZN were utilized to probe the substrate requirements and thermodynamic ligand binding parameters of an unusually selective PZN methyltransferase (BamL) by isothermal titration calorimetry. Our results demonstrate that the presence of a single <i>N</i>-terminal azole permits efficient processing by BamL; however, the substrate binding becomes stronger with increased polyazole chain length

Additional file 1: of Evaluating availability and price of essential medicines in Boston area (Massachusetts, USA) using WHO/HAI methodology

Supplementary details on survey methods, data and statistical analyses. (PDF 874 kb

Pd/Cu-Catalyzed C–H Arylation of 1,3,4-Thiadiazoles with (Hetero)aryl Iodides, Bromides, and Triflates

The direct C–H arylation of 1,3,4-thiadiazoles with a wide range of (hetero)­aryl iodides, bromides, and triflates is described using a Pd/Cu-catalyzed protocol. The methodology is compatible with substrates possessing electron-donating or electron-withdrawing substituents and also tolerates sterically hindered aryl halides. The utility of the developed protocol is demonstrated by a one-pot C–H arylation-Suzuki coupling sequence

ATM deficiency does not impact on the accumulation of Top1-single-strand breaks.

<p>(<b>a</b>) Human lymphoblastoid cells (LCLs) derived from a normal individual ‘WT’, spinocerebellar ataxia with axonal neuropathy ‘SCAN1’, or ataxia telangiectasia ‘A–T’ patients, and mouse embryonic fibroblasts (MEFs) or quiescent cortical astrocytes from control ‘WT’ or <i>Tdp1-/-</i> mice were incubated with DMSO (Mock) or 30 µM camptothecin (CPT) for 40 min with or without pre-incubation with 10 µM ATM inhibitor KU-55933 (ATMi) for 2 hours at 37°C. Top1-single-strand breaks ‘Top1-SSBs’ were quantified by alkaline comet assays (ACAs). Mean tail moments were calculated for 50 cells/sample/experiment and data are the average of <i>n</i> = 3 biological replicates ± s.e.m. (<b>b</b>) Top1-SSBs were analysed in quiescent cortical astrocytes derived from wild-type ‘WT’, <i>Atm-/-</i> or <i>Tdp1-/-</i> mice following incubation with DMSO (Mock) or 30 µM camptothecin (CPT) and quantified as described above.</p