Eosinophilic lymph node abscesses following a COVID-19 vaccination: A case report

In this paper, we reported a 37-year-old man who developed several lymphadenopathies after using the second dose of Pfizer-BioNtech vaccination against SARS-CoV-2. The excisional lymph node biopsy showed eosinophil-rich inflammation with micro-abscesses. Although eosinophilic dermatosis and eosinophilic myocarditis have been described previously following COVID-19 vaccinations, eosinophilic lymph node abscess was not reported in the literature. In our case, all lesions were completely recovered with steroid treatment. The patient has been doing well and no recurrence has been observed for six months

The Effects of Pupil Control Ideology of Teachers on their Conflict Management Strategies

The aim of this study was to determine teachers' perspectives on conflict management strategies and further to determine the effects of pupil control ideologies on their conflict management strategies. 120 primary and secondary school teachers were administered a Likert type questionnaire. The data collected were analyzed through multiple regression analyses and the teachers’ perspectives on conflict management strategies were determined. Moreover, the effects of pupil control ideology of teachers on their conflict management strategies were revealed. The results of this study suggested that teachers preferred integration reconciliation strategy in conflict resolution the most, and domination strategy the least. It was observed that, among the conflict management strategies, teachers’ pupil control ideologies predicted domination strategy positively and integration-reconciliation negatively. Certain suggestions were made based on the findings of the study

Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model

Statin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, 10 and 20 mg kg–1 day–1 doses of both pravastatin and rosuvastatin were administered by oral gavage to the diabetic rats for 8 weeks. At the end of the experiment, body masses, the levels of fasting blood glucose, serum insulin, insulin resistance (HOMA-IR), liver glycogen, and liver enzymes related to carbohydrate metabolism were measured. Both doses of pravastatin significantly increased the body mass in diabetic rats, however, rosuvastatin, especially at the dose of 20 mg kg–1 day–1 reduced the body mass significantly. Pravastatin, especially at a dose of 20 mg kg–1 day–1, caused significant increases in liver glycogen synthase and glucose 6-phosphate dehydrogenase levels but significant decreases in the levels of glycogen phosphorylase, lactate dehydrogenase, and glucose-6-phosphatase. Hence, pravastatin partially ameliorated the adverse changes in liver enzymes caused by diabetes and, especially at the dose of 20 mg kg–1 day–1, reduced the fasting blood glucose level and increased the liver glycogen content. However, rosuvastatin, especially at the dose of 20 mg kg–1 day–1, significantly reduced the liver glycogen synthase and pyruvate kinase levels, but increased the glycogen phosphorylase level in diabetic rats. Rosuvastatin, 20 mg kg–1 day–1 dose, caused significant decreases in the body mass and the liver glycogen content of diabetic rats. It can be concluded that pravastatin, especially at the dose of 20 mg kg–1 day–1 is more effective in ameliorating the negative effects of diabetes by modulating carbohydrate metabolism

Value of a new inflammatory parameter in malignant pleural mesothelioma prognosis

Malignant Pleural Mesothelioma (MPM) generallyassociated with asbestos exposure is a tumor withpoor prognosis. Modified Glasgow Prognostic Score(GPS) which may be a prognostic parameter in patientswith MPM is a designed based score including increasedC-reactive protein (CRP) levels and decreased albumin.In this study we aimed to investigate the effect of GPSscore on the prognosis of MPM and the role of other potentialfactors.Methods: In this retrospective planned study 140 histologicaldiagnosed MPM patients were included.Results: Mean age of 140 MPM patients were 52.92years (83 male and 57 female). A total of 91 patients hadenvironmental asbestos exposure and exposure timewas the 31 years. Symptoms of the patients started approximately4.8 months before the application. The mostfrequently seen symptoms were in 125 patients dyspnea,in 94 patients chest pain and in 22 patients weight loss.GPS score of the patients were as follows; 64 patientstwo, 14 patients one, 22 patients zero. Of the patients,112 died and 28 were alive. Mean survival time was 14months. Patients with GPS score 2 lived for 10 months,GPS score 1 lived for 15 and GPS score 0 lived for 18months. This difference was statistically significant. Furthermore,the male sex and age older than 65 years werefound as poor prognostic parameters on the survival.Conclusion: A simple and inexpensive parameter able tobe used to estimate the prognosis of MPM patients couldnot be developed .GPS score increases in inflammatoryconditions. GPS is a simple and inexpensive parameterthat can be used for detecting the severity of patients withMPM.Key words: Modified Glasgow Prognostic Score, MalignantPleural Mesothelioma, Prognosi

The importance of mean platelet volume in early mortality of pulmonary embolism

Objective: In this study whether mean platelet volume(MPV) is associated with early period hospital mortalityor not in patients with pulmonary embolism (PE) was investigated.Methods: Data of patients that hospitalized in chest diseasesclinic with the diagnosis of PE between the years2009-2012 were screened retrospectively from digital archivesystem. The demographic data, symptoms, treatmentoutcomes and MPV values in complete blood countof patients were recorded.Results: The mean age was 57.93 ± 18.52 years (16-91).The number of patients is 143 and 91 women (63.9%),52 men (36.4%), respectively. MPV values were availablefor 137 of 143 patients. 129 of patients were discharged,and 8 had died in the early period of hospitalization. Themean MPV value was 7.85 ± 1.40 fL in patients who experiencedand 9.08 ± 1.61 fL in died respectively. The differencewas statistically significant (p = 0.01).Conclusion: The results of this study suggests that increasedMPV value may be used as a marker for earlyhospital mortality in patients with PE. J Clin Exp Invest2013; 4 (3): 298-301Key words: Mean platelet volume, mortality, pulmonary embolis

Bloqueio dos nervos ílio‐hipogástrico/ilioinguinal em correção de hérnia inguinal para tratamento da dor no pós‐operatório: comparação entre a técnica de marcos anatômicos e a guiada por ultrassom

ResumoObjetivoComparar a eficácia de bloqueios dos nervos ílio‐hipogástrico/ilioinguinal feitos com a técnica guiada por ultrassom e a de marcos anatômicos para o manejo da dor no pós‐operatório em casos de herniorrafia inguinal em adultos.MétodosForam randomicamente divididos 40 pacientes, estado físico ASA I‐II, em dois grupos iguais: nos grupos AN (técnica de marcos anatômicos) e US (técnica guiada por ultrassom), o bloqueio dos nervos ílio‐hipogástrico/ilioinguinal foi feito com 20mL de levobupivacaína a 0,5% antes da cirurgia com as técnicas especificadas. Escore de dor na avaliação pós‐operatória, tempo de primeira mobilização, tempo de internação hospitalar, escore de satisfação com a analgesia no pós‐operatório, efeitos colaterais induzidos por opiáceos e complicações relacionadas ao bloqueio foram avaliados durante 24horas de pós‐operatório.ResultadosEscores EVA em repouso na sala de recuperação e todos os valores clínicos durante o acompanhamento foram significativamente menores no grupo ultrassom (p<0,01 ou p<0,001). Escores EVA em movimento na sala de recuperação e todos os valores clínicos durante o acompanhamento foram significativamente menores no grupo ultrassom (p<0,001 em todos os tempos avaliados). Enquanto os tempos de internação e da primeira mobilização foram significativamente menores, os índices de satisfação com a analgesia foram significativamente maiores no grupo ultrasom (p<0,05, p<0,001, p<0,001, respectivamente).ConclusãoDe acordo com o nosso estudo, o bloqueio dos nervos ílio‐hipogástrico/ilioinguinal guiado por US em herniorrafias inguinais em adultos proporciona uma analgesia mais eficaz e maior satisfação com a analgesia do que com a técnica de marcos anatômicos. Além disso, pode‐se sugerir que a observação das estruturas anatômicas com a US pode aumentar o sucesso do bloqueio e minimizar as complicações relacionadas ao bloqueio.AbstractObjectivesThe purpose of this study is to compare the efficacy of iliohypogastric/ilioinguinal nerve blocks performed with the ultrasound guided and the anatomical landmark techniques for postoperative pain management in cases of adult inguinal herniorrhaphy.Methods40 patients, ASA I–II status were randomized into two groups equally: in Group AN (anatomical landmark technique) and in Group ultrasound (ultrasound guided technique), iliohypogastric/ilioinguinal nerve block was performed with 20ml of 0.5% levobupivacaine prior to surgery with the specified techniques. Pain score in postoperative assessment, first mobilization time, duration of hospital stay, score of postoperative analgesia satisfaction, opioid induced side effects and complications related to block were assessed for 24h postoperatively.ResultsVAS scores at rest in the recovery room and all the clinical follow‐up points were found significantly less in Group ultrasound (p<0.01 or p<0.001). VAS scores at movement in the recovery room and all the clinical follow‐up points were found significantly less in Group ultrasound (p<0.001 in all time points). While duration of hospital stay and the first mobilization time were being found significantly shorter, analgesia satisfaction scores were found significantly higher in ultrasound Group (p<0.05, p<0.001, p<0.001 respectively).ConclusionAccording to our study, US guided iliohypogastric/ilioinguinal nerve block in adult inguinal herniorrhaphies provides a more effective analgesia and higher satisfaction of analgesia than iliohypogastric/ilioinguinal nerve block with the anatomical landmark technique. Moreover, it may be suggested that the observation of anatomical structures with the US may increase the success of the block, and minimize the block‐related complications

A comparison of machine learning algorithms in predicting COVID-19 prognostics

ML algorithms are used to develop prognostic and diagnostic models and so to support clinical decision-making. This study uses eight supervised ML algorithms to predict the need for intensive care, intubation, and mortality risk for COVID-19 patients. The study uses two datasets: (1) patient demographics and clinical data (n = 11,712), and (2) patient demographics, clinical data, and blood test results (n = 602) for developing the prediction models, understanding the most significant features, and comparing the performances of eight different ML algorithms. Experimental findings showed that all prognostic prediction models reported an AUROC value of over 0.92, in which extra tree and CatBoost classifiers were often outperformed (AUROC over 0.94). The findings revealed that the features of C-reactive protein, the ratio of lymphocytes, lactic acid, and serum calcium have a substantial impact on COVID-19 prognostic predictions. This study provides evidence of the value of tree-based supervised ML algorithms for predicting prognosis in health care

Toz Metalurjisi ile Üretilen Gözenekli TiZr Alaşımının Mekanik Özellikleri ve Biyouyumluluğu Üzerine Sinterleme Sıcaklığının Etkileri

Dünya nüfusunun ortalama yaşam süresi arttıkça implant biyomalzemelerine olan ihtiyaç da artmaktadır. Bu nedenle, bu alandaki araştırmalar son yıllarda artış göstermiştir. Özellikle, gözenekli metaller, ayarlanabilir mekanik ve fiziksel özellikleri ve gözenekli yapısından dolayı implant kemik etkileşimini arttırmasından dolayı daha kullanışlıdır.Bir yenilik olarak, bu çalışmada, sinterleme sıcaklığının Ti-20Zr alaşımlarının mikroyapısı, mekanik ve biyouyumluluk özellikleri üzerindeki etkileri araştırılmıştır.Numunelerin mikroyapılarında meydana gelen değişimler ve faz analizi, taramalı elektron mikroskobu (SEM) ve X-ışını kırınımı (XRD) ile araştırılmıştır.Basma testi kullanılarak numunelerin mekanik özellikleri ve Sprague Dawley dişi ratlar kullanılarak in vivo biyouyumluluk özellikleri incelenmiştir. Deneysel sonuçlara göre, sinterleme sıcaklığı mikroyapı, mekanik özellikler ve biyouyumluluk üzerinde önemli bir rol oynamıştır. Ayrıca implantasyon bölgesinde herhangi bir toksik veya alerjik reaksiyon görülmemiştir. Bu sonuçlar Ti-20Zr alaşımlarının sert doku için umut verici bir implant olduğunu ortaya çıkarmıştır